ABSTRACT
The aim of this study is to evaluate the serum level of the endothilin-1 and the interleukin-18 In patients with polycystic ovary syndrome. A Case Control Study. Ain Shams University Maternity Hospital and Ahmed Maher Teaching Hospital. 45 women will participate in the study divided to two groups. Group A [30 with Polycystic Ovarian Syndrome]. Group B [15 controls]. Patients with PCOS will be recruited from the infertility and gynecological clinics. Control subjects are healthy volunteers with a normal menstrual cycle and with no clinical or biochemical features of hyperandrogenism, thereby excluding the diagnosis of PCOS in this group. Blood Samples will be collected and examined by in-vivo enzyme immunoassay for detection of total human lnterleukin-18 and Endothelin-1 in complex biological body fluids. Results shows that the PCO cases had a higher serum Endotheline-1 level than that of the controls with statistically significant difference; [p <0.001.] and results show that the serum level of Interleukin-18 is greater in PCO patients than that of the controls with statistically significant difference; p = 0.038. PCOS induce an increase in serum IL-18 levels and the endotheline-1 concentration