ABSTRACT
The aim of this study was to evaluate the cytogenetic and immunologic role in human reproduction. The study included 158 women with history of repeated fetal losses, their ages ranged between 18-45 years [mean = 31 years] and the number of previous losses ranged between 2-8 [mean = 4]. The clinical evaluation, pedigree construction, pelvic ultrasound examination was done to all cases. Chromosomal studies were done to 66 couples with history of early fetal losses [during 1st trimester] using GTG-banding technique. A total number of 120 pregnant women with history of fetal losses and 30 normal pregnant women used as controls was subjected to a further immunologic investigation. Anticardiolipin antibodies were measured using ELISA and lupus anticoagulant [LA] by activated partial thromboplastin time [APTT]. The study concluded that both genetic and immunologic factors have been identified as causes of repeated fetal losses. However, chromosomal aberrations play an important role in the etiology of early fetal losses