ABSTRACT
Background: Volumetric evaluation of thyroid gland volume [TGV] is one of the criteria determining the iodine status of a population. TGV is the product of 3 dimension of each lobe: Anterio-posterior [AP] x medio-lateral [ML] x and craniocaudal [CC] x correction factor
Objectives: To determine the effect of serum TSH on thyroid dimensions of each lobe and to measure the amount of effect of per unit increase in serum TSH on thyroid dimensions of each lobe in euthyroids
Study Design: It was a cross-sectional study
Setting: The study was conducted at Ziauddin University Hospital, Clifton, Karachi. Methodology: Healthy participants aged 21 years and above were included through convenient sampling. Serum Thyroid stimulating hormone was evaluated and ultrasound of thyroid gland TG of 192 euthyroid participants was performed. Spearman correlation and regression analysis was applied to evaluate the relationship between TSH and TG dimensions
Results: Relationship of increase in serum TSH with decrease in light lobe AP dimension was most significant. [r= -0.142 P-Value=0.001] and CC dimension least significant [r= -0.0098 P-Value=0.001]. Where as in the left lobe AP dimension decreases significantly with increase serum TSH [r= -0.147 P-value=0.001]. 11.7% of total variation in AP dimension, 3.5% of total variation in ML dimension and 6.5% of total variation in CC dimension in right lobe thyroid are because of serum TSH. While 9.5% of the total variation in AP dimension in left lobe is also due to serum TSH
Conclusion: Negative and significant correlation between serum TSH and thyroid dimensions was observed. Serum TSH inversely and significantly affects all the dimensions of the right lobe and only one dimension in the left lobe
ABSTRACT
Objectives: The aim of this study was to measure the Epicardial Adipose Tissue thickness through echocardiography in healthy adults and coronary artery disease patients and to make its association with age and gender
Methods: It was a case control study. A total of 315 samples including 159 cases of coronary artery disease and 156 asymptomatic individuals for coronary artery disease underwent echocardiography for Epicardial Adipose Tissue thickness measurement
Results: Mean Epicardial Adipose Tissue [EAT] in the study was found to be 15.45 +/- 7.16 mm. Cases had significantly higher EAT 16.77 +/-9.80mm as compared to controls 14.13 +/- 4.52 mm [P=0.02]. EAT thickness increased significantly with age [P=0.004]. There was no significant difference of EAT [P=0.999] in both the genders
Conclusion: The mean EAT thickness is significantly higher in our study population as compared to previous studies. The mean EAT thickness was same in both males and females of our study. There was no significant difference in EAT of both genders