ABSTRACT
Background: Assessment of histopathological pattern of endometrium among women with abnormal uterine bleeding is important for management of this condition
Objective: This study was conducted to find out the histopathological pattern of the endometrium in patients with abnormal uterine bleeding
Patients and Methods: This cross sectional study was conducted in the department of Obstetrics and Gynaecology Unit-II, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from 1[st] January, 2011 to 31[st] December, 2013. Patients with history of abnormal bleeding were assessed and admitted in Gynae Unit-II, after detailed evaluation by history, examination and pelvic ultrasound, their endometrial sampling was taken and sample was sent for histopathological examination in pathology department of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. Inclusion Critaria: Patients with irregular P/V bleeding at any age, menorrhagia, polymenorrhagia, endometrial polyp, post-menopausal bleeding and post-menopausal discharge. Exclusion Critaria: Patients with pregnancy complications [threatened, incomplete miscarriage, molar pregnancy and ectopic pregnancy] acute pelvic infection and IUCD insertion. Data was entered and analyzed by using SPSS version 16
Results: A total of two hundred and thirty six endometrial sampling were performed over a period of three years. In three years majority 166 [70.30%] of patients presented in age of 35-50 years, 47 [19.9%] were between 30-35 years and 23 [9.8%] were more than 50 years of age. The commonest histopathological finding in our study was chronic endometritis [41.5%], followed by simple hyperplasia [19.9%], proliferative endometrium [9.3%], secretary endometrium [7.6%], complex hyperplasia without atypia [5.9%] and complex hyperplasia with atypia [5.1%]. Other findings constitute disordered proliferation [3.4%], adenocarcinoma [1.7%], atrophic and inactive endometrium [1.3%], endometrial polyp [0.4%]
Conclusion: Histopathological pattern of endometrium in patients with abnormal bleeding is quite variable. Main reason for performing endometrial biopsy in women with abnormal uterine bleeding is to confirm the benign nature of the problem by ruling out endometrial carcinoma