ABSTRACT
Trinta e cinco aidéticos entre 19 e 55 anos admitidos e tratados de candidíase no Hospital Emílio Ribas, SP, com ELISA positivo para HIV e confirmado pelo Western Blot. Tuberculose em 9 sendo 2 com pericardite; neurotoxoplasmose em 6; neurocriptococose em 5; herpes labial em 4; pneumocistose em 3 e sarcoma de kaposi em 2, achavam-se associadas. A concentraçäo inibitória mínima 50 por cento (MIC 50 por cento) para os azoles foi: ketoconazol = 2,2 µg/ml; itraconazol = 21,0 µg/ml; fluconazol = 19,0 ég/ml. O MIC 50 por cento para os polienos: nistatina = 50,0 µg/ml; anfotericina B = 0,12 µg/ml e para 5 fluorcitosina = 1,6 µg/ml nas 35 amostras de Candida isoladas. Testes näo paramétricos de Siegel revelaram significante identificaçäo (80 por cento) das Candida albicans na candidíase, e que a dose de AMB näo modificou o número de óbitos, precoce e tardio, ocorridos nesses aidéticos. O uso prévio de azoles e da nistatina explicaria, talves, o elevado MIC 50 por cento observado nas amostras de Candida isoladas
Subject(s)
Adult , Humans , Male , Female , Candidiasis, Oral/diagnosis , AIDS-Related Opportunistic Infections/diagnosis , Antifungal Agents/administration & dosage , Brazil/epidemiology , Chi-Square Distribution , AIDS-Related Opportunistic Infections/microbiology , AIDS-Related Opportunistic Infections/mortality , AIDS-Related Opportunistic Infections/drug therapy , Microbial Sensitivity TestsABSTRACT
Mycobacterium szulgai is a scotochromogenic species recently recognized as a human pathogen. Twenty-nine cases of disease caused by M. szulgai in humans have been reported. Pulmonary disease indistinguishable from that caused by M. tuberculosis was the commonest type of infection caused by M. szulgai. Olecranon bursitis was reported in 3 cases and disseminated infection was noted in 3 cases occurring in immunocompromised patients without AIDS. The authors report the first case of pulmonary disease caused by M. szulgai in Brazil and the first case in patient with AIDS in the world literature.