ABSTRACT
Objective:- The present study aimed at evaluation of the non invasive assessment of endothelial function in offspring of patient with type 2 diabetes mellitus [type 2 DM]
Subject and methods:-The study include 36 healthy subject [mean age 25 +/- 12 year] with one or both parents were type 2 diabetes mellitus, 48 patient with type 2 DM [mean age 58 +/- 10 years] and 12 healthy control subject matched for age [23 +/- 10 years] with no history of diabetes in any of their parents The brachial artery diameter and its vascular reactivity was measured with high resolution ultrasound at rest, endothelial dependant after reactive hypereamia [Flow mediated dilatation [FMD]] and endothelial independent after administration of sublingual nitrate [NMD]
Result:- The result of our study demonstrated that The FMD was significantly low in patient with type 2 DM as compared to the control subjects 14.7 +/- 1.0, 13.9 +/- 1,8, P <0.001]. Also the NMD was significantly lower in diabetic patient compared to control subject [10.1 +/- 3.1, 21.2 +/- 22 P<0.001] The FMD and NMD were comparable among offspring of diabetic patients and their parents On the other hand the rate of blood flow was also significantly decreased in diabetic and their offspring as compared to control subjects
Conclusion:- Study of brachial artery dilatation with high resolution ultrasound is a simple non invasive index of endothelial function FMD and NMD was significantly impaired in diabetic patient FMD and NMD was significantly impaired in offspring of diabetic patient So we recommend that brachial artery reactivity study should be performed in offspring of diabetic patient in regular fashion to pick-up early impairment in endothelial function and dealt with