Gall bladder volume and contractility in type 2 diabetes mellitus

The aim of this study was to sonographically evaluate gall bladder changes in type 2 diabetes. One hundred type 2 diabetic subjects (50 with neuropathy and 50 without neuropathy) and 50 healthy controls un-derwent sonographic evaluation of the gall bladder. Fasting and postprandial gall bladder volumes (FGBV and PPGBV) were measured; and the gall bladder contractility index (GBCI) calculated. The presence of gallstones was also noted. It was found that patients with diabetic neuropathy had a significantly higher FGBV and PPGBV; and lower GBCI; compared with diabetic patients without neuropathy; PPGBV and GBCI also differed significantly from non-diabetic controls. Gallstones were present in 22% of diabetic patients with neuropathy; in 10% of those without neuropathy; and in 8% of controls. We conclude that diabetic patients with neuropathy have significant abnormalities of gall bladder function; presumably due to autonomic nerve dysfunction. These patients also have a higher prevalence of gallstones; suggesting that ultrasound screening may be worthwhile

Assessment of Lung Function Parameters in Nigerian Males with Diabetes

Despite scarce information on the implications of diabetes for pulmonary function; existing evidence suggests that the respiratory system might also be affected by diabetes. We therefore conducted a crosssectional study of pulmonary function in male Nigerian diabetes patients using spirometric indices. Seventy-six male diabetes patients aged 27-80 years were studied at the Endocrinology and Diabetes Clinic at the Obafemi Awolowo University Teaching Hospital; Ile-Ife; Nigeria. Overall; all lung function parameters/volumes studied were significantly lower in the diabetes patients compared with predicted values p=0.000. Patients' ages correlated negatively with all spirometric indices but there was no significant relationship between lung function and fasting blood sugar; body mass index; or diabetic microvascular complications. The implications of abnormal lung function parameters for respiratory disease in diabetes are unclear. Routine tests of pulmonary function are not presently indicated in Nigerian diabetes patients

Comparison of lispro insulin and regular insulin in the management of hyperglycaemic emergencies

This study compared the efficacy and safety of Lispro insulin and regular insulin in the management of hyperglycemic emergencies (HE). Fifty patients who presented in HE to the Emergency unit of Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife participated in the study. Hyperglycaemic emergency was diagnosed when plasma glucose level was >17 mmol/L (300 mg/dl) in the presence of polyuria and polydipsia that warrants emergency hospital admission. Subjects in the Lispro insulin group had a statum dose of 0.3 IU/kg, while those in the regular insulin group had a statum dose of 20 IU equally split between the intravenous and intramuscular routes. Further insulin therapy was by the intramuscular route. Data was analysed using the Statistical package for social sciences (SPSS) version 11. Hyperglycaemia resolved within the first 8 hours in 60 and 40% percent of subjects in the lispro and regular insulin treated groups respectively. The time taken for resolution of hyperglycaemia was similar in both treatment groups, 6.6 +/- 0.8 hours for the lispro insulin group and 7.4 +/- 0.8 hours for the regular insulin group p = 0.51. The number of episodes of hypoglycaemia and hypokalemia in the two treatment groups did not differ statistically (p = 1.0 and 0.38 respectively). Eight (16%) subjects died. Lispro insulin is a safe and efficacious alternative to regular insulin in the treatment of HE

Screening and identifying diabetic patients at risk of foot ulceration: use of the Semes­Weinstein monofilament

The diabetic foot can present with many different problems and the most important clinically are ulceration, amputation, and Charcot neuropathy. The majority of lower limb amputations in patients with diabetes are preceded by foot ulceration. Neuropathy results in loss of protective sensation and the use of 5.07/10 g Semmes­Weinstein monofilament is a simple device that detects patients with insensate feet. Clinical and demographic parameters of all consenting consecutive type 2 diabetes patients were documented. A history of the presence of peripheral neuropathy and sensory modalities of light touch, vibration sense, and joint position were assessed and the 5.07/10 g Semmes-Weinstein monofilament was used to detect patients with insensate feet. A total of 117 patients were examined (mean age 58 years, diabetes duration 6 years: there were 51% males and 49% females, and mean fasting plasma glucose was 8.1±2.9 mmol/L. Ninety-three (79%) presented with a history of peripheral neuropathy and 96% had one or more impaired sensory modality. The use of the monofilament showed impairment in 49%. Twenty-seven (23%) of these had severe peripheral neuropathy. The most frequent site of loss of sensation was the heel (31%). We concluded that the prevalence of peripheral neuropathy in our patients is high. Most patients walked sometimes barefoot, which may account for a high occurrence of foot ulceration. The Semmes-Weinstein monofilament should be routinely used in diabetes clinics