ABSTRACT
No abstract available.
Subject(s)
Adult , Humans , Male , Autoantigens/genetics , Cell Cycle Proteins/genetics , Chromosomes, Human, Pair 8 , Chromosomes, Human, Pair 9 , Janus Kinase 2/genetics , Myeloproliferative Disorders/complications , Sarcoma, Myeloid/complications , Translocation, GeneticABSTRACT
Recent advances in chemotherapy have led to increased survival rates for patients with hematologic malignancies. However, standard chemotherapies, including alkylating agents for non-Hodgkin lymphoma, could induce therapy-related myeloid neoplasms (t-MNs), a group of disorders categorized by the World Health Organization in 2008. Here, we report a case of coexistence of bone marrow (BM)-involved refractory marginal zone B-cell lymphoma (MZL) and therapy-related myelodysplastic syndrome (t-MDS). Simultaneous presence of refractory lymphoma and t-MN in the BM is rare, and this is the first report in Korea. The patient received allogeneic hematopoietic stem cell transplantation (HSCT) to cure both the MZL and t-MDS. Since the HSCT, he has been stable for 21 months without any evidence of recurrence.