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Medical Journal of Cairo University [The]. 2009; 77 (1): 583-589
in English | IMEMR | ID: emr-100972

ABSTRACT

B-cell lymphoma displays striking heterogeneity at the clinical, genetic arid molecular levels. Clinical prognostic models can define a population at high risk for relapse following empiric chemotherapy, although such models do not account for underlying biologic differences among tumors. Despite recent advances in empiric chemotherapy, including interval reduction of CHOP [cyclophosphamide, doxorubicin, vincristine, prednisone] and the incorporation of anti-CD2O monoclonal antibodies, a significant proportion of patients still die of their disease. Gene expression profiling has shed light on the molecular heterogeneity within B cell lymphoma by highlighting similarities between subsets of tumors and normal B cells, identifying features associated with unfavorable responses to empiric combination chemotherapy and defining robust subtypes with comprehensive transcriptional signatures. Commonly observed genetic abnormalities that likely contribute to pathogenesis include translocations of BCL6, BCL2 and MHC class II mutations. Our study showed over expression of some genes e.g. BCL2, interleukin I, interferon receptor and low expression of MHC class H, p53, Fas and casp8-FADD. Our increasing molecular understanding of the heterogeneous subsets within B cell lymphoma will likely improve the current empiric therapy by identifying rational therapeutic targets in specific disease subtypes


Subject(s)
Humans , Male , Female , Oligonucleotide Array Sequence Analysis , Gene Expression , Lymph Nodes , Biopsy , Prospective Studies
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