Association between High-Density Lipoprotein Cholesterol and Vitamin D Levels in Adult Men in the Fifth Korea National Health and Nutrition Examination Survey

BACKGROUND: Patients with metabolic syndrome had low high-density lipoprotein cholesterol (HDL-C) levels. Moreover, vitamin D deficiency is also related to metabolic syndrome. This study aimed to investigate the association between vitamin D and HDL-C levels.METHODS: To determine the association between HDL-C and vitamin D levels, 5,537 males who had no missing values were systematically selected from the fifth Korea National Health and Nutrition Examination Survey. Then, the association was investigated by a multivariable logistic regression analysis after adjusting for the effects of confounding factors on vitamin D and HDL-C levels, such as age, body mass index (BMI), sociodemographic factors, and lifestyle factors.RESULTS: In Korean men aged ≥20 years, the mean vitamin D and HDL-C levels were 18.3±0.2 ng/mL and 46.8±0.2 mg/dL, respectively. Moreover, the prevalence of low HDL-C levels was 29.2±0.8%. After adjusting for age, BMI, sociodemographic factors, and lifestyle factors, the risk of low HDL-C levels in the lowest quartile of vitamin D level was 1.296 (95% confidence interval [CI], 1.035–1.623) times higher and that in the second quartile of vitamin D level was 1.354 (95% CI, 1.086–1.690) times higher than that in the third quartile of vitamin D level (P<0.05).CONCLUSIONS: The risk of low HDL-C levels is associated with vitamin D level after adjustment for age, BMI, sociodemographic factors, and lifestyle factors.

Association between High-Density Lipoprotein Cholesterol and Vitamin D Levels in Adult Men in the Fifth Korea National Health and Nutrition Examination Survey

BACKGROUND@#Patients with metabolic syndrome had low high-density lipoprotein cholesterol (HDL-C) levels. Moreover, vitamin D deficiency is also related to metabolic syndrome. This study aimed to investigate the association between vitamin D and HDL-C levels.@*METHODS@#To determine the association between HDL-C and vitamin D levels, 5,537 males who had no missing values were systematically selected from the fifth Korea National Health and Nutrition Examination Survey. Then, the association was investigated by a multivariable logistic regression analysis after adjusting for the effects of confounding factors on vitamin D and HDL-C levels, such as age, body mass index (BMI), sociodemographic factors, and lifestyle factors.@*RESULTS@#In Korean men aged ≥20 years, the mean vitamin D and HDL-C levels were 18.3±0.2 ng/mL and 46.8±0.2 mg/dL, respectively. Moreover, the prevalence of low HDL-C levels was 29.2±0.8%. After adjusting for age, BMI, sociodemographic factors, and lifestyle factors, the risk of low HDL-C levels in the lowest quartile of vitamin D level was 1.296 (95% confidence interval [CI], 1.035–1.623) times higher and that in the second quartile of vitamin D level was 1.354 (95% CI, 1.086–1.690) times higher than that in the third quartile of vitamin D level (P<0.05).@*CONCLUSIONS@#The risk of low HDL-C levels is associated with vitamin D level after adjustment for age, BMI, sociodemographic factors, and lifestyle factors.

Association of Smoking Status and High Density Lipoprotein-Cholesterol in Males in the Fifth Korea National Health and Nutrition Examination Survey

BACKGROUND: The patients with metabolic syndrome had shown low high density lipoprotein-cholesterol (HDL-C) and smoking had been reported to be an independent risk factor for low HDL-C. This study aimed to study the association of smoking status and low HDL-C in general population of Korea. METHODS: Frequency analysis and descriptive statistics for general characteristics and chi-square test for the association of smoking status and low HDL-C were used. Then, logistic regression analyses for the effect of smoking on low HDL-C and general linear method for HDL-C estimates were used. RESULTS: Univariate regression showed that smoking status showed an association with low HDL-C. Prevalence of low HDL-C was 29.4±0.3% of Korean males in their twenties or over, and low HDL-C possibilities of current and past-smokers compared with non-smokers were odds ratio 1.345 and 1.123 respectively. After adjustments with sociodemographic factors, physical activity, body mass index (BMI), and age, the low HDL-C possibility of current-smokers was 1.328 times higher and for past-smokers was 0.892 times than non-smokers (P < 0.05). The HDL-C concentration of current-smokers was 1.009 mg/dL lower than non-smokers', whereas that of past-smokers' was 0.478 mg/dL higher than non-smokers'. HDL-C concentration decreased 0.922 mg/dL for every 1 unit of BMI increase and 0.080 mg/dL for every 1-year age increase (P < 0.05). CONCLUSIONS: In this study using general population, HDL-C showed significant association with smoking status. The occupation, BMI and age also had significant associations. Conclusively, the possible strategies to maintain serum HDL-C include cessation of smoking, increase of physical exercise, and weight loss.

Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites

BACKGROUND/OBJECTIVES: Nelumbo leaves have been used in traditional medicine to treat bleeding, gastritis, hemorrhoids, and halitosis. However, their mechanisms have not been elucidated. MATERIALS/METHODS: The present study prepared two Nelumbo leaf extracts (NLEs) using water or 50% ethanol. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and nitric oxide (NO) and prostaglandin E₂ (PGE₂) productions were assessed. To determine the anti-inflammatory mechanism of NLEs, we measured nuclear factor-κB (NF-κB) activity. Major metabolites of NLEs were also analyzed and quantified. RESULTS: NLEs effectively reduced the expression and productions of pro-inflammatory mediators such as IL-1β, IL-6, TNF-α, PGE₂, and NO. NLEs also reduced NF-κB activity by inhibiting inhibitor of NF-κB phosphorylation. Both extracts contained catechin and quercetin, bioactive compounds of NLEs. CONCLUSIONS: In this study, we showed that NLEs could be used to inhibit NF-κB-mediated inflammatory responses. In addition, our data support the idea that NLEs can ameliorate disease conditions involving chronic inflammation.

Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice / 한국영양학회지

PURPOSE: In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice. METHODS: C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes low-jaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed. RESULTS: Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities. CONCLUSION: These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.

Relationship between serum 25-hydroxyvitamin D and chronic obstructive pulmonary disease in males in the fifth Korean national health and nutrition examination survey / 한국영양학회지

PURPOSE: The aim of this study was to determine the relationship between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and chronic obstructive pulmonary disease (COPD) prevalence. METHODS: The analysis was performed using data from the Fifth Korean National Health and Nutrition Examination Survey, a cross-sectional survey of the Korean civilian population conducted from 2010 to 2012. The analyses were restricted to males who were 40 years of age and above. Complex sample multiple logistic regression analyses were used to examine the associations of COPD prevalence with 25(OH)D and other factors. RESULTS: FEV1/FEV6 varied significantly with smoking status, age, household income, education level, occupation, body mass index (BMI), and physical activity (p < 0.05). In univariate analysis, smoking status, BMI, household income, education level, and occupation showed association with COPD (p < 0.05), but vitamin D was not associated with COPD (p = 0.078). However, when adjusted with smoking status, household income, education level, occupation, BMI, age, and smoking index, the lowest quartile of 25(OH)D showed OR 1.643 (95% CI 1.161-2.236) compared to 3rd quartile (p = 0.024). CONCLUSION: A significant relationship was observed between serum concentration of 25(OH)D and COPD.

Effects of Smoking Status on Chronic Obstructive Pulmonary Disease Prevalence in Males 40 years and Older: Findings from the Korean National Health and Nutrition Examination Survey

BACKGROUND: This is a study of the prevalence of chronic obstructive pulmonary disease (COPD), which shows high mortality worldwide, and the effects of smoking on COPD by using data from the Korea National Health and Nutrition Examination Survey V. METHODS: FEV1/FEV6<0.73 was used as a diagnostic criterion of COPD. Frequency analysis for prevalence, descriptive statistics for general characteristics and ventilation rate according to age-specifications, and complex sample logistic regression analysis for the effect of smoking on COPD prevalence were used. IBM SPSS Statistics 21 Standard, Complex Samples for Medical Science(Windows) was used for data analysis(alpha=0.05). RESULTS: Prevalence of COPD was 11.6+/-0.5% of Koreans in their forties or over, and 17.5+/-0.8% in males, and 6.2+/-0.5% in females. There was significant increase of COPD prevalence with age increment. Before adjusting for age and smoking index(SI), the COPD possibilities of past and current-smokers compared with non-smoking males were (odds ratio [OR] 2.112 [95% confidence interval [CI] 1.551-2.875]) and (OR 1.834 [95% CI 1.319-2.551]) respectively. After adjustments with age and SI, the COPD possibility of current-smoking was 2.099 (1.382-3.188) times higher and for past-smoking was 1.463 (1.012-2.115) times higher than non-smoking. The P-value of each group was significant. The regression coefficients (B) of current-smoking and past-smoking were 0.741 and 0.380 respectively. The prevalence of COPD increased 1.102 (1.090-1.115) times for every 1 year of age increase, and 1.012 (1.007-1.018) times for every 1 SI increase (P<0.001). CONCLUSIONS: After adjusting for age and SI, the prevalence of COPD in smokers was higher than non-smokers. And current-smoking had a higher OR and higher B than past-smoking.

Prevalence of vitamin D deficiency in Korea: Results from KNHANES 2010 to 2011 / 한국영양학회지

Vitamin D deficiency (VDD) is becoming an epidemic and thereby a global health problem. Further, VDD adversely affects calcium metabolism and skeletal health, and is associated with increased risk of several diseases, e.g., autoimmune diseases, several types of cancers, type 2 diabetes mellitus, cardiovascular diseases, infectious diseases, asthma, psoriatic arthritis, and etc. To evaluate the prevalence of VDD in Korea, and then to evaluate the association of several factors with serum 25(OH)D level, the author analyzed the data of 14,456 individuals who were 10 years of age and over from the Fifth Korea National Health and Nutrition Examination Survey 1 & 2 (KNHANES V-1 & 2) conducted by the Korean Centers for Disease Control & Prevention. As a result, among Koreans (age >== 10years), 65.9% of males and 77.7% of females were below optimum blood serum 25(OH)D (20 ng/mL). VDD is more severe in female than in male at all age groups. In addition, the younger generations had less 25(OH)D level than older generations in Korea. The analysis by complex sample general linear model (CSGLM) suggested that blood 25(OH)D concentration was related with gender (p < .001), residence (p = .030), occupation (p < .001), anemia (p < .001) and physical activity (p < .001). In conclusion, VDD is pandemic and it is more severe in younger generations in Korea. Further, from the results by CSGLM, serum 25(OH)D status is closely related with the life style of Koreans.

Bisphenol A Impairs Mitochondrial Function in the Liver at Doses below the No Observed Adverse Effect Level

Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver. Two doses of BPA, 0.05 and 1.2 mg/kg body weight/day, were administered intraperitoneally for 5 days to mice. Both treatments impaired the structure of the hepatic mitochondria, although oxygen consumption rate and expression of the respiratory complex decreased only at the higher dose. The hepatic levels of malondialdehyde (MDA), a naturally occurring product of lipid peroxidation, increased, while the expression of glutathione peroxidase 3 (GPx3) decreased, after BPA treatment. The expression levels of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) also increased. In HepG2 cells, 10 or 100 nM of BPA also decreased the oxygen consumption rate, ATP production, and the mitochondrial membrane potential. In conclusion, doses of BPA below the NOAEL induce mitochondrial dysfunction in the liver, and this is associated with an increase in oxidative stress and inflammation.

The effects of Internet addiction on the lifestyle and dietary behavior of Korean adolescents

We performed this study to examine lifestyle patterns and dietary behavior based on the level of Internet addiction of Korean adolescents. Data were collected from 853 Korean junior high school students. The level of Internet addiction was determined based on the Korean Internet addiction self-scale short form for youth, and students were classified as high-risk Internet users, potential-risk Internet users, and no risk Internet users. The associations between the students' levels of Internet addiction and lifestyle patterns and dietary behavior were analyzed using a chi-square test. Irregular bedtimes and the use of alcohol and tobacco were higher in high-risk Internet users than no risk Internet users. Moreover, in high-risk Internet users, irregular dietary behavior due to the loss of appetite, a high frequency of skipping meals, and snacking might cause imbalances in nutritional intake. Diet quality in high-risk Internet users was also worse than in potential-risk Internet users and no risk Internet users. We demonstrated in this study that high-risk Internet users have inappropriate dietary behavior and poor diet quality, which could result in stunted growth and development. Therefore, nutrition education targeting high-risk Internet users should be conducted to ensure proper growth and development.

Effects of the Prevention Program on Internet Games Addiction in Middle School Students

No abstract available.

A Study on the Nutrient Intakes and Factors Related to Dietary Behavior of Women by Age Groups in Incheon / 대한지역사회영양학회지

The purpose of this study was to compare the nutrition intakes and factors related to dietary behaviors according to age in female. The subjects included 579 females aged 15 - 59 years. This survey was conducted using a selfadministered questionnaire to obtain data about eating behaviors, living habits, eating disorders by EAT-26 (Eating Attitude Test-26), and nutrition knowledge. In younger women aged 15 - 20 years, the living habits related to health such as smoking, drinking and exercising were undesirable. In addition, the younger women group had significantly higher levels of skipping meals and frequency of eating snacks compared to the older women group and their eating times were not regular. And they showed a lower score of health eating index by mini dietary assessment (MDA). Although, all age groups consumed energy, Ca, Fe, and thiamin below the Korean RDA; especially, in adolescent, Ca intakes (67.1% RDA) were extremely low. In addition, mean score of EAT-26 was significantly higher in young women aged 15 - 29 years than older women. Also, they had rather lower levels of accuracy and perception for nutrition knowledge compared to older age group. These results suggested that Korean adolescent had undesirable nutritional intakes and attitude, and nutrition knowledge, indicating inadequate eating behaviors. These poor dietary behaviors can affect the health status. Therefore, the nutrition counseling and education to help people to have correct nutrition knowledge and to form better eating habits needs to be established.

Supplementary Effect of the High Dietary Fiber Rice on Blood Glucose in Diabetic KK Mice

This study was carried out to investigate the supplementary effects of Suwon 464, which has over two times of dietary fiber content compared with normal rice (Ilpum), on blood glucose in diabetic mice. We supplied 5 kinds of experimental diets (corn starch diet as a control (CO), Ilpum polished rice diet (IP), Ilpum brown rice diet (IB), polished rice diet (SP) and brown rice diet (SB) of Suwon 464) to diabetic mice for 8 weeks, after analyzing dietary fiber contents of 5 experimental diets. Diet intake, body weight and contents of blood glucose, hemoglobin A(1c) and insulin were measured. The dietary fiber contents in CO, IP, IB, SP, and SB diets were 1.0, 1.2, 1.4, 1.4, and 2.0% respectively. Body weight was lower in SB group than the other groups though there was no significant difference in diet intake among experimental groups. The concentration of blood glucose in diabetic mice was lower in SB group than the other groups during the supplementary period of experimental diets. The hemoglobin A(1c) and serum insulin levels were lower in SP and SB groups. These results suggested that the brown rice of Suwon 464 with high dietary fiber can control diabetes in diabetic mice by reducing the blood glucose and hemoglobin A(1c).

A Case of Apical Hypertrohic Cardiomyopathy Associated with Pheochromocytoma / 대한내분비학회지

Pheochromocytomas often present with cardiovascular manifestations, such as arrhythmia, angina pectoris and acute myocardial infarction and so on. Both dilated and nonobstructive hypertrophic cardiomyopathies are also rare complications of pheochromocytomas. In hypertrophic cardiomyopathy, an apical variant form constitutes about 25% of cases in Japan, but only 1 to 2% of those in non-Japanese populations, including Korea. The cause of apical hypertrophic cardiomyopathy (AHC) remains unknown. Recently, some cases of AHC associated with pheochromocytomas have been reported, with catecholamine thought to be an important cause. AHC associated with a pheochromocytoma has never been previously reported in Korea. Herein is reported our experience of a case of apical hypertrophic cardiomyopathy associated a pheochromocytoma with a review of the literature

Korean Adult Growth Hormone Deficiency Treatment Registry / 대한내분비학회지

BACKGROUND: Adult growth hormone (GH) deficiency is related with decreased lean body mass, increased body fat, and poor quality of life. In western countries, adult GH deficiency treatment registriesy provide a database of the effects and safety of GH deficiency treatment. The Korean Adult Growth Hormone Study Group of the Korean Society of Endocrinology register adult GH deficiency since 1996. METHEODS: Subjects were aged over 15 years, had organic hypothalamo-pituitary disease, and GH deficiency as documented by GH stimulation test or serum insulin-like growth factor-I (IGF-I) level. The underlying etiology for GH deficiency, serum IGF-I level, starting and maintenance dose, and adult GH deficiency assessment (AGHDA) score were investigated. RESULTS: From January 1996 to May 2001. 115 patients were enrolled. Mean age was 43.7 13.8 years and 60% were female. Thirteen medical institutions were involved in the registry. The most common underlying diseases were Sheehan's syndrome and pituitary adenomas. GH starting dose was from 0.4 to 1.0 units. Maintenance dose was between 0.5 and 1.2 units. Serum IGF-I levels were increased after GH treatment (0-week, 93.7 69.7 ng/mL; 2-weeks, 184.9 89.0 ng/mL; 6-weeks, 188.4 94.8 ng/mL; 10-weeks, 207.6 111.1 ng/mL; 6 months, 281.9 95.5 ng/mL). AGHDA scores slightly improved from 10.25 6.70 to 8.58 5.47 after 6 months of GH deficiency treatment. CONCLUSION: The GH Treatment Registry will be beneficial in monitoring the effects of GH deficiency treatment on Korean adult GH deficient subjects

Pseudoinfections Due to Benzalconium-chloride Solution Contaminated with Burkholderia cepacia / 감염

No abstract available.

The Diagnostic Value of a Low Dose (1ug) Rapid ACTH Stimulation Test to Assess the Adrenocortical Function / 대한내분비학회지

BACKGROUND: Insulin induced hypoglycemia has been used to assess the adrenocortical function, but may be hazardous. The standard rapid ACTH stimulation test has been advocated as a substitute but is sometimes insensitive. In this study, low dose (1ug) rapid ACTH stimulation test was compared to insulin induced hypoglycemia and standard dose (250ug) rapid ACTH stimulation. METHODS: 27 patients (14 men and 13 women) with pituitary disease and definite adrenocortical dysfunction (14 patients were confirmed by insulin induced hypoglycemia) and 23 controls (pituitary control: 3 men and 7 women, confirmed by insulin induced hypoglycemia, normal control: 8 men and 5 women) were studied. All subjects underwent rapid ACTH stimulation test with 2 different level of stimulation (1 and 250ug). Serum cortisol levels were measured at 0, 30 and 60 min after each dose of ACTH injection. A normal response was defined as a peak cortisol value of 497nrnol/L (18ug/dL) or above, RESULTS: During rapid ACTH stimulation study in controls, the peak serum cortisol level was significantly lower (690+-25lnmol/L (25.0+-9.1ug/dL) vs. 933+-257nmol/L (33.8+-9.3ug/dL); p0.1). None of these 27 patients showed normal response to low dose stimulation, but 2 of 27 did to standard dose. In controls, 19 of 23 showed normal response to low dose, and all of 23 did to standard dose (sensitivity 100% vs 92.5%, specificity 82.5% vs 100%). The results of low and high dose stimulation test agreed with those of insulin induced hypoglycemia (Kendalls g= 0.50 vs 0.92, p<0.01 vs 0.001). CONCLUSIONS: The results of a low dose (1ug) rapid ACTH stimulation test showed good correlation with those of the standard dose (250ug) rapid ACTH stimulation test and insulin induced hypoglycemia. Thus it may be used in screening for the diagnosis of adrenal insufficiency.

Expression of Exon 1 and 6 of Indulin-like Growth Factor / 대한내분비학회지

Background: Goiter has been a common problem in the thyroid disease. The exact mechanism of goiter had not been clarified yet, but some goiters were increased with TSH(thyrotropin releasing hormone) dependent manner. TSH might be a major influencing factor for increasing size of goiter(goitrogen) and theres many cofactors those influenced to goiter size. One of the rnost prominent growth factor as a goitrogen is a IGF-I(insulin-like growth factor-I). IGF-I play a great role as a cofactor of goitrogen with TSH. This study, therefore, is aimed to investigate intracellular activation of IGF-I gene promoter in the surgical specimens of thyroid tumor. Methods: We used surgical specimen of various thyroid tissues from normal to malignant along its cell nature. Actually we used normal liver tissue as a IGF-I control tissue, normal thyroid, benign adenoma, and papillary thyroid cancer tissue with its malignat nature. We checked Mrna expression of whole IGF-I and IGF-I exon 6 by Northern blot method, and IGF-I, promoter 1 expression by RT-PCR-transcription method. Autoradiographied signals were analysed with densitometer. Results: We found whole IGF-I mRNAs were expressed with alternate splicing in exon 1, 2 and exon 4, 5 respectively. Striking events of IGF-I transcription were multiple tranascription initiatian in Pl and P2, and 3 sites for polyadenylation in exon 6. Four or more Mrna bands in Northern blot analysis of IGF-I(0.8, 1.4, 4.2, and 7.8kb) were noted. In low molecular weight IGF-I Mrna did not change their signal intensity with tissues, but exan 6(7.8kb) signals were significantly increased to its hepatic expression levels in malignant tissue. IGF-I, exon 1 expression by RT-PCR-T7 transcription was strikingly increased in thyroid cancer tissue, but exon 6 expression was not a great expession. Conclusion: One possible guess for this expression discrepancy of each exon may be originated from different Mrna degradation of each IGF-I signals. We need more preeise experiment for Mrna degradation speed of IGF-I.

A Study of Point Mutations of Human Insulin-like Growth Factor / 대한내분비학회지

Background: FSS is a normal variants in Korea, but some of them had defect of noctumal GH pulse i.e. neurosecretory dysfunction. Although Korean children had strikingly got higher final height in the last decade. We are interested in what kinds of differences were existed in FSS group. Previous study showed theres no difference of GH related biochemical markers between normal and FSS group, like IGF-I, IGFBP-3 etc. We analyzed molecular difference in FSS group. Methods: We screened 23 FSS patients and 16 normal controls to IGF-I gene prornoter region with PCR-SSCP (single strand conformation polymorphisrn) method and sequenced 1 FSS patients who had abnormal SSCP band. Results: We found 1 out of 23 patients with abnormal SSCP band (none for 16 controls). Their IGF-I promoter gene were sequenced with modified Maxam-Gilbert method. One subject had 2 point mutations(+8 and +74). Conclusion: We found point mutations of IGF-I promoter in FSS group, This position was regarded as HNF(hepatic nuclear factor)-3 binding sites. We needed more study for the detection of its biological function according io linear growth with in vivo and in vitro study.