ABSTRACT
BACKGROUND: Obesity is a complex problem that is now considered a chronic metabolic disease. In Korea, phentermine has been widely used for the treatment of obesity in the primary care setting since 2004. However, there have been very few studies on the safety and efficacy of phentermine. To investigate the safety and efficacy of this drug, a postmarketing surveillance study was performed. METHODS: A total of 795 patients with obesity (body mass index > or = 25 kg/m2) were enrolled from 30 primary care centers in Korea from September 2006 to November 2007. Patients were examined to ascertain safety and efficacy at 4-, 8-, and 12-week intervals. The criterion for efficacy was defined as a weight loss > or = 5% of body weight. RESULTS: Of the 795 enrolled patients, 735 (92.5%) were evaluated in safety assessments and 711 (89.4%) was included in efficacy assessments. A total of 266 adverse events (AEs) were reported by 218 patients (30.6%), and no serious AEs were reported. Among 711 patients, 324 patients (45.6%) lost > or = 5% of their body weight. The mean weight loss was 3.8 +/- 4.0 kg. CONCLUSION: AEs are commonly associated with phentermine, even though phentermine is effective for weight loss and relatively well-tolerated.
Subject(s)
Humans , Body Weight , Korea , Metabolic Diseases , Obesity , Phentermine , Primary Health Care , Weight LossABSTRACT
The fiberscope is no longer an experimental instrument, and it is a state-of-the-art technique for airway management in the operating room, recovery room, and intensive care unit. Changing the oral tube to a nasal one is often necessary if the trachea is to be intubated for a long period. A nasal tube is better tolerated by the patient, is easier to secure when the patient is moved, and is easier to attach to the respiratory care equipment. We describe three cases report changing the oral tube to a nasal one in neurosurgical pa- tient post operatively under flexible fiberoptic laryngoscope, while the interruption of venti- lation is minimized.
Subject(s)
Humans , Airway Management , Intensive Care Units , Laryngoscopes , Operating Rooms , Recovery Room , TracheaABSTRACT
Blind nasotrscheal intubation with preformed tube has been attempted in 20 conscious young male scheduled for surgical reduction of mandibular fracture. The patient was premedicated in the usual fashion with glycopyrrolate -midszolam- fentanyl. Airway anesthesia was performed with topical lidocaine ; Nasopharyngeal and translaryngeal. Of the 20 patients in whom intubation was performed, 12 (60%) required one to three attempts, 6 (30%) required four to six, and only two failures occurred. Contrary to our expectation, this procedure met with almost positive acceptance by the patients in the series, and the surgical staff had no adverse criticism. In addition to the effectiveness and ease of learning, this technique is simple and free from major morbidity.
Subject(s)
Humans , Male , Anesthesia , Fentanyl , Glycopyrrolate , Intubation , Learning , Lidocaine , Mandibular FracturesABSTRACT
No abstract available.
Subject(s)
Humans , Infant, Newborn , Osmolar Concentration , Specific GravityABSTRACT
No abstract available.