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Objective@#To assess the incidence of urinary tract infection (UTI) with post-urodynamic study (post-UDS) in patients with spinal cord injury (SCI) and study its relationship with pre-UDS pyuria. @*Methods@#Patients with SCI who were hospitalized and underwent UDS during a 4-year period were reviewed. Patients with pre-test lower urinary tract symptoms were excluded. Urinalysis and urine culture were performed before and 24 hours after UDS. Prophylactic antibiotics were administered for 5 days starting from the morning of the UDS. UTI was defined as bacteriuria with accompanying symptoms. @*Results@#Of 399 patients reviewed, 209 (52.4%) had pyuria in pre-UDS urinalysis, and 257 (64.4%) had bacteriuria in pre-UDS culture. Post-UDS UTI occurred in 6 (1.5%) individuals who all complained of fever: 5 (2.4%) of the post-UDS UTI cases occurred in patients with pre-UDS pyuria, and 1 (0.5%) in a person without. The differences between groups were not statistically significant (p=0.218). Of 221 patients with bacteriuria (gram-negative isolates) on pre-UDS culture, resistance to ciprofloxacin, cephalosporin, and trimethoprim/sulfamethoxazole (TMP/SMT) was noted in 52.9% (117 cases), 57.0% (126 cases), and 38.9% (86 cases), respectively. @*Conclusion@#No difference was found in the prevalence of post-UDS UTI based on the presence of pyuria in pre-UDS urinalysis. UDS may be performed even in SCI cases of pre-UDS pyuria without increasing the prevalence of post-UDS UTI if prophylactic antibiotics are administered. TMP/SMT could be used as a first-line antibiotic for the prevention of post-UDS UTI in Korea.
ABSTRACT
Objective@#To assess the incidence of urinary tract infection (UTI) with post-urodynamic study (post-UDS) in patients with spinal cord injury (SCI) and study its relationship with pre-UDS pyuria. @*Methods@#Patients with SCI who were hospitalized and underwent UDS during a 4-year period were reviewed. Patients with pre-test lower urinary tract symptoms were excluded. Urinalysis and urine culture were performed before and 24 hours after UDS. Prophylactic antibiotics were administered for 5 days starting from the morning of the UDS. UTI was defined as bacteriuria with accompanying symptoms. @*Results@#Of 399 patients reviewed, 209 (52.4%) had pyuria in pre-UDS urinalysis, and 257 (64.4%) had bacteriuria in pre-UDS culture. Post-UDS UTI occurred in 6 (1.5%) individuals who all complained of fever: 5 (2.4%) of the post-UDS UTI cases occurred in patients with pre-UDS pyuria, and 1 (0.5%) in a person without. The differences between groups were not statistically significant (p=0.218). Of 221 patients with bacteriuria (gram-negative isolates) on pre-UDS culture, resistance to ciprofloxacin, cephalosporin, and trimethoprim/sulfamethoxazole (TMP/SMT) was noted in 52.9% (117 cases), 57.0% (126 cases), and 38.9% (86 cases), respectively. @*Conclusion@#No difference was found in the prevalence of post-UDS UTI based on the presence of pyuria in pre-UDS urinalysis. UDS may be performed even in SCI cases of pre-UDS pyuria without increasing the prevalence of post-UDS UTI if prophylactic antibiotics are administered. TMP/SMT could be used as a first-line antibiotic for the prevention of post-UDS UTI in Korea.
ABSTRACT
The purpose of this study was to examine the impact of the self-perceived stress of high school students on their oral health care and the relationship between stress and oral health care. The subjects in this study were the students in four different high schools located in Chungcheongnam-do, on whom a self-administered survey was conducted. The answer sheets from 939 respondents were analyzed by PASW Statistics ver.18.0 for Windows. The girls were more stressed than the boys about their studies, appearance and material resource, and the sophomores felt more stress about their home and studies. The group whose academic achievement was good in the past semester had the lowest stress about home and material resource, and the group whose economic standard was higher were less stressed about appearance and material resource. As a result of comparing their oral health care by general characteristics, the groups who were sophomores and whose academic achievement was good in the past semester were most excellent in that regard, and the students whose economic standard was higher and whose average weekly allowances were larger took better care of their oral health. Concerning the influential factors for oral health care, stress about peer relationship was positively related, and stress about material resource was negatively related. Given the findings of the study, the development of oral health care programs that include how to relieve stress is required, and more intensive education is necessary as well. Besides, education for school personnel in charge of student health management and the development of related manuals are both required.
Subject(s)
Female , Humans , Education , Oral Health , Surveys and QuestionnairesABSTRACT
Subject(s)
Follow-Up Studies , Hyoid Bone , Mandible , Mouth , Osteotomy, Sagittal Split Ramus , Prognathism , Retrospective Studies , TongueABSTRACT
Subject(s)
Humans , Eosinophilic Granuloma , Facial Asymmetry , Facial Bones , Mandible , Molar , Osteotomy, Sagittal Split Ramus , Pierre Robin Syndrome , Surgery, OralABSTRACT
OBJECTIVE: The purpose of this study was to compare the cephalometric measurements of obese and non-obese Korean male patients with obstructive sleep apnea syndrome (OSA). METHODS: Eighty-seven adults who had visited the Sleep Disorder Clinic Center in Keimyung University, Daegu, Korea were examined and evaluated with polysomnography (PSG) and lateral cephalogram. They were divided into 4 groups (non-obese simple snorers, obese simple snorers, non-obese OSA patients, obese OSA patients) according to AHI (Apnea-Hypopnea Index) and BMI (Body Mass Index). RESULTS: The obese OSA group had the highest AHI among the 4 groups. The non-obese OSA group had a significantly steeper mandibular angle and shorter tongue length than the obese OSA group. The hyoid bone of the obese OSA group was positioned anterior and inferior as compared with the non-obese OSA group. Multiple regression analysis showed that tongue length in the obese OSA group and retroposition of hyoid bone in the non-obese OSA group were significant determinants for the severity of AHI. CONCLUSIONS: From a cephalometric point of view, the obese and non-obese pateints with OSA may be characterized by different pathogeneses. Therefore, they have to be managed by individualized treatment. For the obese OSA patients, weight control must be advised as a first choice and for the non-obese OSA patients, oral appliance, nasal CPAP, UPPP and others could be chosen according to the obstructive sites.
Subject(s)
Adult , Humans , Male , Hyoid Bone , Korea , Polysomnography , Sleep Apnea, Obstructive , TongueABSTRACT
Subject(s)
Adult , Humans , Rabbits , Allografts , Autografts , Bone Matrix , Edetic Acid , Hand , Osteogenesis , Parietal Bone , Skull , Surgery, Oral , TransplantsABSTRACT
Central granular cell odontogenic tumor(CGCOT) is a very rare lesion that consists of densely packed granular cells with numerous scattered strands of odontogenic epithelium interspersed throughout the tissue. CGCOT was initially reported in 1962 by Cough et al as central granular cell ameloblastic fibroma. But, recently, this term is inappropriate because of histologic and chronologic differences. CGCOT is usually present as painless swellings. Radiographs show a well-demarcated radiolucent or mixed radiopaque-radiolucent lesion. The average age on presentation of CGCOT is 47.3 and women are 75% more likely to develop this lesion than men. The tumor only occur in tooth bearing areas of the jaw with 88% of cases occurring in the mandible and 12% involving the maxilla, usually in an equal distribution between the caninepremolar-molar areas. This tumor is benign, and care is effected by localized surgical excision. We report an additional case of CGCOT that occurred in the Rt. Maxillar premolar/molar region of a 32-year old man with literature review.
Subject(s)
Adult , Female , Humans , Male , Ameloblasts , Cough , Epithelium , Fibroma , Immunohistochemistry , Jaw , Mandible , Maxilla , Microscopy , ToothABSTRACT
PURPOSE: Infants and children with cardiovascular diseases often present with respiratory symptoms. However, missed or delayed evaluation for potential airway problem may complicate overall prognosis. The aim of this study is to determine the clinical characteristics of these patients and explore the cause of airway problem. METHODS: We reviewed the medical records of 64 patients (M: F=33: 31, mean age: 6.3+/-7.5 months) whose airway problems were proven by computed tomography or bronchoscopy in perioperative periods at the Asan Medical Center from January 1997 to June 2004. Patients were divided into two groups based on the duration of ventilator care: 7 days (group 2: 41 cases, M: F=23: 18). RESULTS: The patients in group 2 significantly developed more post-operative respiratory symptoms than group 1 (P< 0.001) and had more airway problems including extrinsic obstruction, intrinsic anomaly, and combined problem than group 1 although not significantly different (P=0.082). Among underlying diseases, the most common diseases were vascular anomaly (26.2 percent) and aortic arch anomaly (26.2 percent) in group 1 and pulmonary atresia with ventricular septal defect (22.4 percent) in group 2. The most frequent respiratory symptoms were recurrent wheezing pre-operatively and failure of ventilator weaning post-operatively. The major types of airway anomaly were tracheomalacia and tracheal stenosis (in each case 18.2 percent). Nineteen patients with persistent airway problems underwent aortopexy or other vascular correction. Of the 19 patients, 13 (68.4 percent) were improved, but 2 failed in weaning ventilator and 4 died of non-airway problems. CONCLUSION: Early evaluation and treatment for potential airway problems may affect natural or surgical prognosis in patients with cardiovascular diseases presenting with respiratory symptoms.
Subject(s)
Child , Humans , Infant , Aorta, Thoracic , Bronchoscopy , Cardiovascular Diseases , Heart Septal Defects, Ventricular , Medical Records , Perioperative Period , Prognosis , Pulmonary Atresia , Respiratory Sounds , Tracheal Stenosis , Tracheomalacia , Ventilator Weaning , Ventilators, Mechanical , WeaningABSTRACT
BACKGROUND: Although it has become obvious that male osteoporosis represent a public health issue, few studies has been done in Korea concerning the association between grip strength and bone mineral density(BMD) in men. This study was undertaken to enforce the necessity of muscle strengthening exercise program to improve BMD in middle-aged men by evaluate the association between grip strength and BMD. METHODS: The study was performed from January to December 1998 in the health screening center of CHA hospital with 174 men who measured both BMD and grip strength . BMD was measured at the proximal and distal radius of the dominant hand using Osteoplan p-DXA and grip strength was measured from the dominant hand using dynamometer. Daily calcium intake was measured through the interview with the diet therapist. Other datas were obtained from the questionnaire. RESULTS: We found a significant positive correlation between grip strength and BMD of distal and proximal radius(r=0.208; P<0.01, r=0.255;P<0.01)and a significant negative correlation between age and BMD of distal and proximal radius(r= -0.313; P<0.01, r= -0.190; P<0.05). There was no correlation between calcium intake and BMD. BMI was correlated significantly only with BMD of distal radius(r=0.194; P<0.05). There was no significant difference in BMD either by smoking or exercise. The multiple regression analysis showed that grip strength was independently correlated with BMD of the proximal radius significantly(beta =1.731, P<0.05), but not with BMD of the distal radius after adjusting the confounding variables. CONCLUSION: In conclusion, there is a significant correlation between grip strength and BMD in middle aged men. Therefore it can be safely concluded that it is helpful to carry out muscle strengthening program to improve muscle strength and increase BMD for preventing male osteoporosis.
Subject(s)
Humans , Male , Middle Aged , Bone Density , Calcium , Diet , Hand , Hand Strength , Korea , Mass Screening , Muscle Strength , Osteoporosis , Public Health , Radius , Smoke , Smoking , Surveys and QuestionnairesABSTRACT
BACKGROUND: The prevalance of coronary heart disease is significantly higher in men than in premenopausal women of the same age. Impact that endogenous androgens have on serum lipid has many arguments and few researches were made in Korea. So this study was made to investigate correlation between total testosterone and serum lipid known as effect on cardiovascular disease. METHODS: This was a cross sectional study on 560 middle aged men undertaken health screening program in Pundang General Hospital, Korea from June 1999 to June 2000. We surveyed informations concerning exercise, consumption of alcohol and smoking by means of self questionnaire records and total testosterone and serum lipid were measured at fasting state. RESULTS: Body mass index was positively correlated with total cholesterol and triglycerides(r=2.023;P<0.01, r=0.229;P<0.01) but negatively correlated with HDL cholesterol(r= 0.284;P<0.001). Total testosterone concentrations were negatively correlated with total cholesterol and triglyceride(r= 0.096; P<0.05, r= 0.145; P<0.01) but positively correlated with HDL cholesterol(r=0.155; P<0.001). Total testosterone concentrations were independently correlated with HDL cholesterol after age and body mass index were adjusted(beta=0.734; P<0.05). And after statistical adjustment for age, body mass index, exercise, smoking and alcohol, total testosterone concentrations were significantly correlated with triglyceride(beta= 10.467; P<0.05). CONCLUSION: The result indicate that total testosterone can be a independent determinant of HDL cholesterol and we expect that appropriate maintenance of total tetosterone concentrations will have a protective effect for cardiovascular disease.
Subject(s)
Female , Humans , Male , Middle Aged , Androgens , Body Mass Index , Cardiovascular Diseases , Cholesterol , Cholesterol, HDL , Coronary Disease , Fasting , Hospitals, General , Korea , Mass Screening , Smoke , Smoking , Testosterone , Surveys and QuestionnairesABSTRACT
In this study, the effect of surface modification of polymethylmethacry-late[PMMA]by grafting of poly[ethylene glycol][PEG]on cell adhesion was investigated. PMMA surface was treated with ozone and then PEG-acry-late[PEGA]was graft-polymerized. Ozone treatment of the surface was car-ried out at room temperature by applying constant flow of oxygen[4.5liter/min]and 1 bar pressure. After ozone treatment, PMMA was immersed immediately in 20 wt%aq. PEG-acrylate solutions in glass ampoules. After degassing, the ampoule was sealed and kept at 60 degrees C for 24 hours to complete the graft polymerization. PMMA surface grafted with PEG revealed the enhanced oxygen content at ESCA analysis and the decreased dynamic receding contact angles. The adhesion of keratocytes onto modified PMMA was investigated. Keratocytes[4 x105cells/milliliter ]were layered on each PMMA discs which were glued to the bottom of 24-well culture plates, and cultured in a CO2 incubator for 24 hours. The adherent cells onto the surfaces were harvested by trypsinization and counted. The mean numbers of keratocytes on untreated PMMA, PEG-grafted PMMA with 1hour ozone treatment and PEG-grafted PMMA with 2 hour were 72.5 x104 and 6.5 x104 and 7.6 x104cells respectively, and there was a significant statistical difference [p=0.002], irrespective of ozone treatment period. This result suggests that surface modification of PMMA using PEG grafting may reduce etroprosthetic membrane formation of artificial cornea.
Subject(s)
Cell Adhesion , Cornea , Glass , Incubators , Membranes , Oxygen , Ozone , Polymerization , Polymers , Polymethyl Methacrylate , Transplants , TrypsinABSTRACT
To determine whether mitomycin-C[MMC]treatment induces apoptosis in cultured keratocytes. Cultured rabbit keratocytes were exposed to MMC[up to 0.4 milligram/milliliter]or phosphate-buffered saline[PBS]for 5 minutes. Light and transmission electron microscopic examination, DNA electrophoresis, and flow cytometric analysis with propidium iodide staining were performed 24 hours after MMC or PBS treatment. A characteristic findings consistent with apoptosis were observed under both light and electron microscopic examination and DNA ladder pattern was shown on electrophoresis. The average percentages of apoptosis measured by flow cytometric analysis were as follows;0.16 +/-0.08%in PBS, 0.23 +/-0.13%in 0.1 milligram/milliliter MMC, 0.50 +/-0.13%in 0.2 milligram/milliliter M M C , and 6.50 +/-1.57%in 0.4 milligram/milliliter MMC. Significant differences were shown in the percentage of apoptosis among the groups based on Kruskal-Wallis test[p=0.005]. Clinically relevant doses of MMC induces apoptosis in cultured keratocytes proportionally. This results suggest that MMC may modulate corneal wound healing process by accelerating the resolution phase of wound healing.
Subject(s)
Apoptosis , DNA , Electrophoresis , Mitomycin , Propidium , Wound HealingABSTRACT
No abstract available.
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User package program run on PC was developed for clinical spirometric test, which enabled to perform popular FVC, SVC, and MVV test items in a very convenient manner. In addition, a program module for research was implemented to study breathing pattern of a patient. The program written in C language was designed to run on Windows OS, and consisted of patient information management, test procedure control, results print out, and accumulation of parameter values in a customized data base which made possible future clinical research and quality assurance. When engaged with the previously developed respiratory air flow measurement unit, the system resulted in an accurate enough performance in that FVC data showed a high correlation coefficient of higher than 0.98 with an imported system. The technician tried the present system under clinical environment and judged the convenient utility to be satisfactory. Therefore, industrialization effort is being currently made and expected to be successful.
Subject(s)
Humans , Information Management , Respiration , Spirometry , Industrial DevelopmentABSTRACT
To elucidate the prevalence and clinical implications of antineutrophil cytoplasmic antibody(ANCA) in lupus nephritis(LN), we examined ANCA by indirect immunofluorescence and by ELISA against anti-MPO antibody and anti-lactoferrin antibody. To discriminate pANCA with antinuclear antibody(ANA), all the ANCA positive sera were tested again after incubating patients' sera with single stranded(ss) and double stranded(ds) DNA. To exclude possible cross-reactivity of anti-MPO antibody with lactoferrin, we also performed anti-MPO ELISA with sera preincubated with lactoferrin. These results were correlated with clinicopathologic manifestations and clinical courses of LN. ANCA was positive in 19(37.3%) out of the 51 LN patients. Among these LN patients, 3 had cANCA and 16 had pANCA. ANCA were not found in 8 SLE patients without nephritis and 30 normal controls. The presence of ANCA, particularly pANCA, was associated with the presence of nephritis(19/51 cases vs 0/8 cases, P<0.05), especially diffuse proliferative lupus nephritis(WHO class IV)(17/18 cases vs 21/31 cases, P<0.05) as well as the presence of anti-ds DNA antibody(17/19 cases vs 18/30 cases, P<0.05). Patients with ANCA more frequently had deterioration of renal function than those without it(3/16 vs 0/26 cases). Anti-lactoferrin antibody was positive in 13 patients. Among those, 5 didn't have ANCA, 7 had pANCA, and 1 had cANCA. The presence of anti-lactoferrin antibody was correlated to the low initial creatinine level[serum creatinine(mg/dl):0.78(0.6-1.0) vs 1.43(0.5-5.0), P<0.05]. Anti-MPO antibody was positive in one patient with cANCA and 6 patients with pANCA. However, in 6 patients, the anti-MPO activity was inhibited if tested after preincubation of the serum with lactoferrin. These data suggested that compared with lactorerrin, MPO is a rare antigen for ANCA in LN.