ABSTRACT
In an attempt to understand the prognostic significance of p53, apoptosis and sIL-2R in cancer breast, their serum levels were evaluated in 15 breast cancer patients by enzyme linked immunoassay. While, DNA fragmentation was assessed as a marker of apoptosis using photometric sandwich ELISA technique. Ten healthy women as controls were also included. A significant increase in serum p53 [8.18 +/- 0.4 u/ml] and apoptosis [1.56 +/- 0.32 u/ml] was recorded in cancer patients than in the control [6.29 +/- 0.38 u/ml and 0.114 +/- 0.009 u/ml, respectively]. This increase was positively correlated with the stage of carcinoma. A significant increase in serum sIL-2R was also observed in patients [1156.74 +/- 176.27 u/ml] than in the control subjects [774.145 +/- 40.641 u/ml]