ABSTRACT
Prevalence of thalassemias and/or hemoglobinopathies, particularly hemoglobin E, and cholangiocarcinoma were found more prominently in the lower part of the Northeast of Thailand as compared with the upper part of this region or any other area of the country. The aim of this study was to evaluate if there was coincident distribution or some relationship. Hemoglobin typing by the cellulose acetate method was performed in 111 cases of cholangiocarcinoma, mainly diagnosed by ultrasonography, compared with 146 normal controls. It was found that hemoglobin E trait and beta-thalassemia trait were significantly higher in the former group.
Subject(s)
Adult , Aged , Bile Duct Neoplasms/blood , Bile Ducts, Intrahepatic , Case-Control Studies , Cholangiocarcinoma/blood , Female , Hemoglobin A2/metabolism , Hemoglobin E/metabolism , Hemoglobinopathies/complications , Hemoglobins/metabolism , Humans , Male , Middle Aged , Thailand/epidemiology , beta-Thalassemia/complicationsABSTRACT
Low-dose ARA-C (10 mg/m2 subcutaneous injection twice/day for 20 days with 10 days rest) was prescribed in 8 cases of newly diagnosed ANLL. Only one case attained complete remission in 2 courses and lasted for one and a half years without maintenance therapy. She was 63 years of age. The drug could be tolerated well and no serious side effect was observed.
Subject(s)
Adolescent , Adult , Antimetabolites, Antineoplastic/administration & dosage , Cytarabine/administration & dosage , Female , Humans , Leukemia, Myeloid, Acute/drug therapy , Male , Middle Aged , Remission InductionABSTRACT
A case of full blown systemic lupus erythematosus (SLE) was treated with steroid. The patient was in remission with low dose of prednisolone for a year. When she became pregnant, there was no relapse of SLE activities in any organ. However, she developed gum bleeding and petechiae due to thrombocytopenia in the second half of the pregnancy. With a normal amount of megakaryocyte in the bone marrow, it was supposed to be due to SLE which no longer responded to even a full dose of steroid. Therefore, danazol 600 mg/day was given orally and she made a complete recovery within one week. She delivered vaginally a normal female newborn without fetal thrombocytopenia or bleeding.
Subject(s)
Adult , Anti-Inflammatory Agents/therapeutic use , Danazol/therapeutic use , Estrogen Antagonists/therapeutic use , Female , Humans , Lupus Erythematosus, Systemic/drug therapy , Prednisolone/therapeutic use , Pregnancy , Pregnancy Complications, Hematologic/drug therapy , Pregnancy Outcome , Thrombocytopenia/drug therapyABSTRACT
It seems that thalassemia and/or hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency (G-6-PD) have some protective effects against malaria infection. To verify this, hemoglobin typing and methehoglobin reduction test were performed on 115 malaria patients and compared with controls. It was found that the number of thalassemia/hemoglobinopathies in the malaria group and in the control group were not significantly different and also occurrence of G-6-PD deficiency in the malaria group was not different from that of the controls. Clinical manifestations of malaria in any group are quite similar. It is concluded that there is no protective effect against malaria in thalassemia/hemoglobinopathies or G-6-PD deficiency.
Subject(s)
Adolescent , Adult , Aged , Cross-Sectional Studies , Developing Countries , Erythrocytes/enzymology , Female , Glucosephosphate Dehydrogenase/blood , Glucosephosphate Dehydrogenase Deficiency/enzymology , Hemoglobinopathies/enzymology , Humans , Incidence , Malaria/enzymology , Male , Middle Aged , Risk Factors , Thailand/epidemiology , Thalassemia/enzymologyABSTRACT
A case of hereditary coproporphyria was reported, he was a 21-year-old farmer, presenting with abdominal pain and fever. His manifestations were composed of all classical symptoms of acute hepatic porphyrias i.e. convulsions, psychosis, hypertension and respiratory failure as well as dark red urine with positive Watson-Schwartz test. Because of lack of cutaneous photosensitivity and strikingly increased urinary coproporphyrin, diagnosis of hereditary coproporphyria was most likely. Precipitating factor could not be identified. He responded well to glucose and other symptomatic treatment during the first admission but not in the second. He died from respiratory failure.