ABSTRACT
To determine the role of immune-histochemistry in characterization of undifferentiated malignant tumors. Immunohistochemical staining [IHC] performed was Streptavidin-biotin method on paraffin sections, using mono- or polyclonal antibodies and kits manufactured by DAKO corporation [Dako, Denmark A/S]. The technique was applied on 127 cancer cases reported as undifferentiated malignant tumors over a 12 month period, from July 2008 to August 2009. Undifferentiated malignant tumors were more frequently located in the respiratory tract 30 [23.6%], followed by the gastrointestinal tract 25 [19.7%], lymph node 19 [14.9%] and bone/soft tissue 19 [14.9%]. Among these, 75 [82.7%] cases were primary and 22 [17.3%] metastatic. Application of immunohistochemistry resulted in characterization of 112 [88.2%] cases. Non-Hodgkin lymphotma 21 [16.5%] was at the top of the diagnosed list followed by adenocarcinoma 20 [15.7%], sarcoma 17 [13.4%], and small undifferentiated carcinoma 15 [11.8%].Immunohistochemistry is a very helpful tool for characterization of undifferentiated malignant tumors
ABSTRACT
To analyze the role of immunohistochemistry in characterization of malignant round cell tumors. Immunohistochemical staining [IHC] with [monoclonal or poly-clonal] antibodies was performed on 127 cancer cases reported as malignant round cell tumors over a 12 month period from July 2008 through August 2009. Department of histopathology, Duhok Central Labs. Malignant round cell tumors were more frequently located in the respiratory tract 30 [23.6%] followed by gastrointestinal tract 25 [19.7%], lymph node 19 [14.9%], and bone/soft tissue 19 [14.9%]. Among these, 75[82.7%] cases were primary and 22 [17.3%] metastatic. Application of immunohistochemistry resulted in characterization of 112 [88.2%] cases. Non-Hodgkin lymphoma 21 [16.5%] was at the top of the diagnosed list followed by adenocarcinoma 20 [15.7%], sarcoma 17 [13.4%], and small undifferentiated carcinoma 15 [11.8%].Immunohistochemistry is a very helpful tool for characterization of malignant round cell tumors
ABSTRACT
Synovial sarcoma is a rare soft tissue sarcoma in the foot. It is commonly localized in the extremities, especially the lower thigh and knee areas. The histopathological immunohistochemical, and cytogenetic findings of a foot synovial sarcoma are described