ABSTRACT
To determine the effects of herbal drugs in Hypercholesterolemia, Experimental Study, This study was conducted in the Department of Pharmacology, University of Karachi from Jan. 2007 to Dec, 2008. In the present study experiments regarding lipid profile were performed on rabbits of either sex, the calculated dose was administered for 30 days and 60 days [High dose and low dose group], Alfagin possess wide therapeutic range and is comparatively safe, animals of neither group showed no gross toxicity, No death occurred in control and test animals, Alfagin has been shown having, lowering capability of cholesterol. It has been concluded that Alfagin is beneficial in hypercholesterolemia
ABSTRACT
Doxorubicin an anthracycline antibiotic and antitumour agent is one of the highly effective antineoplastic drug for the treatment of several different human cancers. The clinical use of this drug is limited by its cardiotoxicity including dose related arrhythmias and often irreversible add from discussion cardiomyopathy. The inotropic and chronotropic activity of different doses of doxorubicin was first evaluated and after determining the fixed effective dose of doxorubicin, the beta receptor activity of doxorubicin was evaluated. The effect of propranolol on heart in presence of doxorubicin was evaluated. Thirty male rabbits weighing 1000 - 1500 grams were used. Drugs used were Doxorubicin and Propranolol. The actions of drugs were studied on the isolated heart of these animals. Krebs ringer buffered physiological solution was prepared and used. To perform the experiment complete set of Lagendroff's apparatus was used. Recording was done on graph paper. Other accessories used were isometric transducer, thermostat oxygen, one ml graduated insulin syringe [to inject the test samples]. Pate of contraction of heart and amplitude of contraction was measured [in centimeters] from baseline. Results were calculated statistically on S.P.S.S. We have evaluated the physiological interactions of Doxourbicin with Adrenaline [agonist] in the first part of the study and in this study the interaction with antagonist [Propranolol] has been studied to evaluate the effects leading to up or down regulation of b receptors
ABSTRACT
Ibuprofen is the first member of the class propionic acid introduced in 1969. It is better-tolerated analgesic as compared to aspirin. All members belonging to propionic acid group inhibit prostaglandins, easily absorbed on oral administration, enter brain, synovial fluid and cross placenta, largely metabolized in liver by hydroxylation and glucuronic conjugation excreted in urine as well as in bile. It has analgesic, antipyretic and anti-inflammatory effects. It is commonly used in rheumatoid arthritis, osteoarthritis, and other musculoskeletal disorders. It is useful drug but cannot be considered free of adverse effects, the side effects comprise of milder gastric discomfort, nausea and vomiting, headache, dizziness, blurring of vision, tinnitus, depression, rashes, itching and other hypersensitive phenomena. Anaphylactic shock has also been reported, salt retention and hypertension has also been reported in elderly patients. In our study we noticed 10 male and 25 female patients developing gastric discomfort on prolonged use of ibuprofen. Two females patients have been noted developing analgesic headache. 5 male and 2 female observed nausea. 3 males and 2 females reported dizziness. 2 male patients were observed to have fixed drug eruptions