ABSTRACT
Diabetes is associated with increased inflammatory biomarkers and decreased paraoxonase-1 activity and total antioxidant capacity. The aim of this study was to evaluate the effect of hazelnut on hs-CRP, total antioxidant capacity and paraoxonase-1 activity in type 2 diabetes. In an 8-week randomized clinical trial, 50 patients were assigned to either the control or intervention groups. Hazelnuts replaced 10% of total daily calorie intake in the intervention group. Blood samples were obtained at the start and at the end of week 8. Dietary data were obtained using 24-dietary recall and were analyzed by Nutritionist IV software. All data were analyzed by SPSS version 15. Compared with baseline, total antioxidant capacity decreased in both groups, but at the end of the study, there were no statistical differences between two groups. Also, no differences were observed in Fasting blood sugar [FBS], paraoxonase-1 activity and hs-CRP levels. Hazelnuts consumption had no effect on FBS, hs-CRP, total antioxidant capacity and paraoxonase-1 activity in type 2 diabetic patients
ABSTRACT
Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract [BVFE] which have important role in regulation of serum glucose and fat metabolism in-vivo and in-vitro but its role in type 2 diabetes have not been extensively examined. The aim of this study was the effect of BVFE on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. In a double-blind randomised clinical trial, 31 diabetic patients were randomly assigned to 3 g/d BVFE or placebo for 3 months. Serum glucose, lipoproteins, apoB, apoA-I, insulin, homocysteine and HbA1c were measured at the baseline and also at the end of the 3[rd] month. At the beginning and end of 1[st], 2[nd] and 3[rd] months, a 24-h dietary recall questionnaire about each patients was completed. Data were analyzed by SPSS version 16. There were significant decreases in serum TG, TC, LDL-c, apo B, glucose, and insulin and also a significant increase in TAC at the end of the study in BVFE group compared to the control group [p = 0.001, p = 0.001, p = 0.001, p = 0.001, p = 0.002, p = 0.01 and p = 0.0001 respectively]. There were significant differences in serum TG [p = 0.0001], TC [p = 0.001], LDL-c [p = 0.001], apoB [p = 0.001], glucose [p = 0.002], insulin [p = 0.01], TAC [p = 0.005], and insulin resistance [p = 0.01] between the two groups at the end of the study; but homocysteine, HbA[1c] and HDL-c showed no significant changes between the two groups at the end of study. The intake of 3 g/d BVFE for 3 months may have benefical effects on lipoproteins, apoproteins, glycemic control and TAC in type 2 diabetic patients
ABSTRACT
The prevalence of Diabetes Mellitus [DM] has increased in recent decades. This study was designed to determine retinopathy, neuropathy, nephropathy, hypertension and hyperlipidemia and their interdependence in newly diagnosed diabetic patients. In this study, 200 consecutive newly diagnosed patients were evaluated and screening tests for retinopathy, neuropathy, nephropathy, hypertension and hyperlipidemia were undertaken. The frequency of positive screening tests for hyperlipidemia, hypertension, neuropathy, nephropathy and retinopathy was found to be 73.5%, 58.5%, 52%, 10%, and 6% respectively. A significant proportion of newly diagnosed diabetic patients have signs of these chronic complications