ABSTRACT
Rifampicin continues to be an effective drug for treatment of tuberculosis. A variety of drug reactions have been reported of which hepatotoxicity is well known. This study was conducted to investigate the effects of ascorbic acid as dietary supplementation in case of Rifampicin induced hepatotoxicity. Animal house NIH [National Institute of Health]. Randomized control trial. Thirty adult BALB/c mice weighing 30-60 grams were taken. They were kept under standard laboratory conditions. Mice were randomized and divided into three groups A, B and C each containing 10 mice. Group A was given Rifampicin 100 mg/kg body weight, group B was administered Rifampicin 100 mg/kg body weight along with ascorbic acid 500 mg/kg body weight orally and group C was given regular NIH lab diet for six weeks. Liver specimens of animals given rifampicin showed formation of necrotic foci. Simultaneous administration of ascorbic acid significantly reduced histological changes induced by Rifampicin. Ascorbic acid has protective role against hepatotoxic effect of Rifampicin used in chemotherapy of tuberculosis in animal models
ABSTRACT
To study the effects of electromagnetic radiations on follicles of Thyroid gland of mice, Laboratory based randomized controlled trials. The study was carried out in department of Anatomy. Army Medical College Rawalpindi in collaboration with National Institute of Health, Islamabad from November 2009 to November 2010. Twenty adult Balb/C male mice were divided randomly into two study groups, comprising of 10 animals in each group. Group A was kept under experimental conditions without mobile phone exposure, group B exposed to radiations for 1 hour /day, for two months from mobile phone set. Thyroid glands were removed and sectioned after exposure period. Sections were stained with hematoxylin and eosin for microscopic examination. Results showed statistically significant difference in number and mean size of Thyroid follicles in gland of experimental groups. Thus it is concluded that exposure to EMFs causes decrease in size and increase in number of follicles of thyroid gland of mice, indicating hyperactivity of gland