ABSTRACT
Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin [Cyp] and deltamethrin [Del] and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats
Materials and Methods: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals. Group A served as control, group B was exposed to Cyp [2 mg/kg.bw], group C was exposed to Del [2 mg/kg.bw], group D was exposed to Cyp+Del [2 mg/kg.bw each], group E was exposed to Cyp+Del and treated with curcumin [100 mg/kg.bw], group F was exposed to Cyp+Del and treated with quercetin [100 mg/kg.bw] and group G was exposed to Cyp+Del and treated with quercetin+curcumin for 45 days
Results: Exposure to Cyp and Del caused decreases in reproductive organs weight, sperm count, sperm motility, level of sex hormones viz. testosterone [T], follicle stimulating hormone [FSH] and luteinizing hormone [LH], steroidogenic enzymes viz. 3beta-hydroxyl steroid dehydrogenase [3beta-HSD] and 17beta-HSD, non-enzymatic antioxi- dant glutathione [GSH] and enzymatic antioxidants viz. superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], glutathione-S-transferase [GST] and glutathione reductase [GR] activity and increases in sperm abnormalities and lipid peroxidation [LPO]. The exposure also adversely affected the histo-achitecture of testes. Single and combined treatment with curcumin and quercetin significantly ameliorated Cyp and Del-induced damage in reproductive system
Conclusion: Curcumin and quercetin protected against Cyp and Del-induced reproductive system toxicity and oxidative damage in rats. The increases in activities of 3beta-HSD and 17beta-HSD with concomitant increases in testosterone were mainly responsible for ameliorating effects of curcumin and quercetin. Curcumin showed slightly better activity as compared to quercetin. The combination of both antioxidants offered more protection compared to each one alone
ABSTRACT
This report describes stridor caused by a rare laryngeal tumour. The patient had presented to ENT with a midline neck-mass and stridor of acute onset and diagnosed radiologically as a mass in the right lobe of thyroid gland in continuity with enhancing polypoidal mass in trachea at the same level. Total thyroidectomy along with the resection of the mass and tracheal ring was performed, trachea being anastomosed primarily. Histopathology reported it as a paraganglioma of the larynx. The patient has been followed-up for 5 years with no clinical or radiological recurrence of the tumour