ABSTRACT
Background: Dyslipidemia is the third component of metabolic syndrome and is a wellknown cardiovascular risk factor. However, the association of dyslipidemia with gestational diabetes mellitus is still a subject of ongoing research in Nigerian obstetric populations.Objective: To determine the relationship between second trimester maternal fasting plasma lipid constituents and gestational diabetes mellitus.Methods: This was a prospective nested case control study that enrolled 288 pregnant women out of which 36 women with GDM (cases) where matched with 72 without GDM (controls) following results of oral glucosetolerance testing and plasma fasting lipid profiles done between 24 28 weeks. The patients were followed up until delivery to document maternal and fetal outcomes. Data was analyzed using Statistical Package for Social Sciences (SPSS). Categorical variables were presented in percentages while continuous variables were expressed as means (±Standard Deviation). Student ttest and Chisquare test or Fishers exact test were used for comparing variables between the two groups. A value of <0.05 at 95%confidence interval was considered statistically significant.Results: The overall mean plasma lipid levels for the four lipid constituents in the study population were 187.9mg/dL, 163.5mg/dl, 49.1mg/dL and 108.1mg/dL for TC, TG, HDLc and LDc respectively. The mean plasma triglyceride was significantly higher in cases compared to the controls: 187.0±67.7mg/dL vs. 151.7±66.4mg/dL, (p = 0.01). Abnormaltriglyceride was significantly associated with GDM (AOR:4.8, 95% CI (1.6-14.4), (p= 0.005).Conclusion:Maternal dyslipidemia (abnormal triglyceride) was shown to be significantly associated with GDM in this study and it appeared to be causally related
Subject(s)
Diabetes, Gestational , Lipids , Nigeria , PregnancyABSTRACT
Background and Aims of Study: Malaria in pregnancy remains one of the infectious diseases threatening the health of pregnant women and the unborn child in Africa. The use of Sulphadoxine-Pyrimethamine (SP) as intermittent preventive treatment of malaria in pregnancy (IPTp) has been shown to greatly reduce the impact of malaria in pregnancy and its complications when administered appropriately according to set protocol. The aim of this study is to ascertain the appropriate use of SP among pregnant women who received ante-natal care (ANC) and determine its relationship with feto-maternal outcome. Place and Duration of Study: Daughters of charity Primary Health Center, Kubwa, Abuja, between January 2010 and June 2011. Methodology: A retrospective study of 200 pregnant women, who attended ANC, delivered and followed-up to post-natal clinic at Daughters of Charity primary health centre and was administered SP between January 2010 and June 2011. Ante-natal records were retrieved and socio-demographic variable, number of doses of SP received as well as feto-maternal outcome were collected and analyzed. Results: The use of IPTp among pregnant women in this facility is low, accounting for only 6% of the study population, while 79% were not administered IPTp throughout their pregnancy. Majority of the primigravida (61 out of 70) who were more vulnerable to malaria in pregnancy did not receive any dose of IPTp. Conclusion: More effort is required to increase IPTp coverage in the community. This may be achieved by improving the awareness of IPTp among health care workers, pregnant women and the entire community at large.