Effects of losartan vs enalapril on the markers of metabolic syndrome

To compare the effects of losartan and enalapril on the markers of metabolic syndrome. One hundred and twenty six newly diagnosed hypertensive patients having other markers of metabolic syndrome participated in this study. The study was performed in the department of pharmacology, college of medicine at Ibn-Sina Teaching Hospital in Mosul city, Iraq, during the period between December 2007 and June 2009. The patients were divided into 2 main groups: 1] Losartan group: consisted of 60 patients, and 2] enalapril group: Consisted of 66 patients. Waist circumference, weight, Body mass index, blood pressure, serum glucose concentration, triglyceride and HDL-cholestrol were measured before and after administration of therapy. The effects of therapy were assessed by statistically comparing the results before and after the drug administration. Comparison of waist circumference, blood pressure, FSG, triglycerides of the patients before drug administration [baseline data], with those of the controls showed a significant elevation, while HDL-cholesterol showed a significant reduction. A significant reduction of waist circumference, BP, FSG and a significant elevation of HDL-cholesterol were also noted after therapy with both losartan and enalapril. Both losartan and enalapril produced a significant reduction of markers of metabolic syndrome and may be regarded as effective drugs for treatment of hypertension in patients with markers of metabolic syndrome

[ effect of olive oil on blood pressure, sugar and lipid profile]

The present study was done to evaluate the beneficial effect of olive oil on BP, blood sugar and lipid profile in 16 patients suffering from NIDDM [Non Insulin Dependent Diabetes mellitus] associated with risk factors involving hyperlipidaemia and blood pressure in Mosul population. The period of the study was as long as two months and the dose of olive oil was tablespoonful three times daily. Blood presure, blood sugar, total cholesterol, total triglyceride, HDL-cholesterol and LDL-cholesterol were evaluated before [baseline] and after olive oil administration. The study showed a statistical significant reduction of the all measured parameters after olive oil administration. In the meantime BP, blood sugar, total cholesterol, total triglyceride, and LDL-cholesterol were dropped to normal values in 4 [44%], 4 [50%], 7 [46%], 6 [100%] and 7 [46%] patient, respectively. This study was concluded that olive oil administration be effective in the treatment of diabetes mellitus, hyperlipidaemia and elevated BP, and may be administered as adjunctive to the primary therapy of such disorders

Effect of chlordiazepoxide in patients with major depression

This is a study of different aspects of the problem of urgent traumatic cases admitted to the Accident and Emergency Department Saddam General Hospital, Mosul The study presents Information on the magnitude of the problem facing an accident department. The emphasis is on the pattern of injuries and on those who really need admission. A total number of 2810 traumatic cases were admitted to the Accident and Emergency Department during the period from January 1992 to January 1993. The patients were evaluated and classified according to age, sex, type and cause of injuries, timing of admission and hospital stay. The result shows that the majority of patients were male [72%] with male: female ratio of 2.6:1.0 and children aged below 10 years constituted [31.3%]. The average time of hospitalization was 2.4 days and majority of cases [86.8%] were discharged shortly after arrival. Most of the cases [48%] were due to direct blunt trauma, fall comes next [24.3%] The commonest time of admission was between 3 pm to 12 midnight, and 8 am to 3 pm [52.2%] and [42.2%] respectively. August, September and October were the months of high Incidence [37%]. The implication of these findings on future planning is discussed

Trihexyphenidyl abuse

Twenty trihexyphenidyl [THP] abusers were studied. They had a mean age of 30.5 years. Fifteen of them were employed and 6 of them were married. In addition to THP some of them were alcohol and polydrug abusers with poor educational and social skills, who abused THP mainly for its euphorogenic properties. The 3 major diagnostic categories were antisocial personality disorder, depression and polydrug abuse. The present study concluded that the abuse of THP is of particular interest and concern because of the apparently low level of awareness among physicians regarding its abuse potential, beside; its abuse does not seem to be sufficiently recognized by psychiatrists