ABSTRACT
Abnormalities in left ventricular relaxation are indicators of left ventricular [LV] diastolic dysfunction. LV diastolic dysfunction may occur in patients with LV hypertrophy in the absence of systolic dysfunction. The purpose of this study is to assess the prevalence of LV diastolic dysfunction in patients with left ventricular hypertrophy in Pakistani population. 200 consecutive patients age 20 years and above and of either sex with left ventricular hypertrophy were included in this study. LV diastolic function was assessed by pulsed wave Doppler studies measuring transmitted E and A-wave velocities, E/A ratio, deceleration time and Isovolumic relaxation time intervals. LV diastolic dysfunction was diagnosed. Out of 200 patients, 106 [53%] were male and 94 [47%] were female. The average age was 53.66 +11.07 years. The average body surface area of male patients was 1.79 + 0.19 and female patients was 1.59 + 0.16 m2. The average LV mass of male patients was 290.09 + 68.29 and of female patients was 242.23 + 54.34 grams. 92 [46%] patients had LV diastolic dysfunction. 58 [61.70%] of female patients and 50 [47.17%] of male patients had LV diastolic dysfunction [P=0.04]. The average age of patients with LVDD was 55.55 + 10.86 years as compared to 50.27 + 10.38 years in patients without LVDD [P=0.001]. The mean body surface area of patients with LVDD was 1.667+0.202 as compared to 1.738+0.199 of patients without LVDD [P=0.014]. Ejection fraction and LV mass were not different statistically in patients with or without LVDD. LVDD is a frequent finding in patients with left ventricular hypertrophy. It is more frequent ir female patients with advancing age and smaller body surface area
ABSTRACT
Rheumatic heart disease is a common cardiovascular disease in our country. These patients are referred to echocardiography laboratory for the evaluation of valvular lesions. In this study we are presenting the echo-cardiographic data of patients with mitral stenosis referred to our lab during 2006. We have retrospectively analyzed the data of patients with mitral stenosis [MS]. A total of 3393 echo studies were performed during this year. Out of these 70 patients had significant MS. Of these 42[60%] were female and 28[40%] were male patients. The mean age of these patients was 41.13 +/- 12.64 years [Range 17-70 years] and the median age of 40 years. The mean age of patients with mild MS was 48.63 +/- 12.38 years, with moderate MS was 40.33 +/- 12.52 and with severe MS was 34.67 +/- 9.12 years. All patients had dilated left atrium and normal sized left ventricle. The mean diameter of left atrium was 45.65mm. The mean of MVA by planimetry was 1.28 +/- 0.39 cm2 and by pressure half time method was 1.25 +/- 0.35 cm2 [P=0.366]. The mean MVA in female patients was 1.33 +/- 0.31cm2 and 1.21 +/- 0.49 cm2 and in male patients was 1.21 _0.31 cm2 and 1.28 +/- 0.39 cm2 by planimetry and PHT methods respectively. The mean of mean pulmonary artery pressure was 49.26 +/- 26.82 mmHg. In female patients it was 44.49 +/- 22.33 mmHg and in male patients 57.35 +/- 32.0 mmHg [P=0.024]. 19[27.1%] patients had mild MS, 33[47.1%] moderate and severe in 18[25.1%] patients. Mitral regurgitation was present in 36[51.4%] patients, tricuspid regurgitation in 33[49.1%] patients and 13[18.6%] patients had calcification on leaflets or commissures