ABSTRACT
We measured fasting serum total cholesterol [TC], triglycerides [TG], and low- and high-density lipoprotein cholesterol [LDL-C and HDL-C] levels in 5000 individuals. Coronary artery disease [CAD] was present in 31%. Compared with women, men had lower mean TC, LDL-C and HDL-C and higher mean TG. Optimal TC level was observed in only 46% of men and 41% of women, and optimal TG in 42% of men and 50% of women. Only 3% of men and 12% of women had HDL-C > 60 mg/dL. Mean TC was not different in CAD patients and those without CAD, but mean TG was significantly higher and mean HDL-C was lower. In all age groups, low HDL-C was more prevalent among men and women who had CAD
Subject(s)
Female , Humans , Male , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Triglycerides/blood , Coronary Artery Disease/etiology , Risk Factors , Age Distribution , Sex Distribution , Coronary Artery Disease/bloodABSTRACT
Persistent severe hypoglycemia in the neonatal period is a rare condition, and hyperinsulinism is the most common cause. Its diagnosis is of a great importance as it may be exceedingly difficult to control. Nesidioblastosis is a term used to describe the presence of numerous abnormal clusters of insulin secreting cells histopathologically throughout the pancreas. The aetiology is unknown. That there may be a genetic component with an autosomal recessive inheritance pattern is suggested by its familial occurrence.We report its occurence in 3 sibs of a Jordanian family. The first is a baby girl FTND, birth weight 4.1 kgm, died at the age of 6 days due to severe hypoglycemia, the second is a baby boy delivered by cesarean section because of a large fetus, birth weight 5 kgm, died at the age of 31 days with histological evidence of nesidioblastosis, the third is a baby girl delivered at 36/40, birth weight 3.7 kgm, hypoglycemic investigated and treated by 95% pancreatectomy, well and alive. Our report gives more evidence of its mode of inheritance and confirms the importance of early recognition and efficient treatment in preventing irreversible brain damage
Subject(s)
Hypoglycemia , Chromosome AberrationsABSTRACT
Three patients are described in whom Hirschsprung's disease was associated, in varying degree, with deafness, disturbance of facial configuration and deficient pigmentation of the skin and its appendages; expressing developmental defects of the anterior end of the neural crest. The anomalies described are seen, not as separate and fortuitously associated lesions, but rather as different aspects of a single developmental disturbance of the anterior end of the neural crest. In sporadic reports[14-17] [as shown in text] a substantial experience of such patients is recorded, though texts on pediatric surgery rarely quote this