ABSTRACT
The absolute rest of Gastrointestinal tract is leading to mucousal destitution and atrophy because of intestinal mucous dependent on luminal feeding for life. The important of prophylactic treatment against stress ulcer in ICU patients was obvious. This study have done to evaluate effects of drugs on gastric feeding tolerance in ICU patients. In this clinical trial study, 50 patients were randomly divided in two groups and received ranitidine or sucralfate for stress ulcer. The demographic variables [age, sex, weight], APACHE II score, TISS, episodes of dairrhea, emesis and gastric retention > 250 CC/6h have been determined in both groups. The data was analyzed by SPSS software using Chi2and T-test and fisher exact test and Mann-Whitney U tests. There were no statistical differences about demographic variables in both groups [P>0.05]. Comparison about the important difference wasn't between APACHE II and TISS scores. The rate of diarrhea and emesis in sacralfate group were lesser than ranitidine group [P<0.05]. Against stress ulcer, prophylaxis with sucralfate has better effect on gastric gavage tolerance than ranitidine