ABSTRACT
Background: Erection dysfunction, weakness, the inability to achieve an erection or hold the erection long enough to reach sexual relationship is said. Prevalence studies indicate that 20 to 22 percent of men around the world suffer from erectile dysfunction. Several methods have been proposed to improve this process but those have been unsuccessful mainly due to multiple complications
Objective: The aim of this study was assessing the effects of administration of Boswellia serrata and Lavandula angustifolia extracts in improving erection dysfunction following opioid dependence
Methods: Both plants were extracted and formulized for administration. Choosing patients was based on medical standards, questionnaire of International Index of Erection Function and standard criteria test. The proper cases were categorized randomly in one of three groups under study regarding DSM5 criteria. The investigation continued for two month for all groups: oral extract administered group, placebo treatment group and no premature treatment as a control group. The scores gained form fast ejaculating questionnaire were assessed in early stages of treatment [pretest], one month after treatment [posttests], and two month after treatment [fallow]
Results: The results showed with regarding inter group causes; the F value calculated for assessing drug effect in recovery of premature ejaculation in various stages would be meaningful in the level of 0.05 [F=3.601, P<0.05]
Conclusion: It seems that, administration of Boswellia serrata and Lavandula angustifolia extracts compounds can be effective in recovery of erection function in opioid addicted patients
Subject(s)
Humans , Male , Plant Extracts/therapeutic use , Boswellia , Lavandula , Substance-Related Disorders/drug therapy , PhytotherapyABSTRACT
Background: Premature ejaculation is the most common disorder in men. Different methods have been proposed to recover this problem while, often most of them have been unsuccessful in practice due to multiple after comes
Objective: Our study aimed to compare the effect of combination extracts of [Boswellia serrata] and [Lavandula angustifolia] and placebo on recovery of premature ejaculation
Methods: Both plants were extracted and formulized for administration. Choosing patients was based on medical standards, questionnaire of premature ejaculation and standard criteria test. The proper cases were categorized randomly in one of three groups under study regarding DSM5 criteria. The number of samples in each group has hypothesized 30 and investigation continued for two month for all groups: oral extract administered group, placebo treatment group and no premature treatment as a control group. The scores gained form fast ejaculating questionnaire were assessed in early stages of treatment [pretest], one month after treatment [posttests], and two month after treatment [fallow]
Results: The results showed that combination therapy with plant extracts was significantly potent to reduce premature ejaculation performance scores index than placebo and control group; the F value calculated for assessing drug effect in recovery of premature ejaculation in various stages will be meaningful in the level of 0.05 [F=14.23, P<0.05]
Conclusion: It seems that, compounds of [Boswellia serrata] and [Lavandula angustifolia] extract can be effective in recovery of premature ejaculation opioid addicted patients. The mechanism and effective ingredients causing this effect are needed to be further investigated
ABSTRACT
The sudden involuntary muscular contractions of the air ways is a very common disease in human societies. Study on medical plant extracts to affect contractile activity of the tracheal smooth muscle can be useful manner in control of pulmonary obstructive sickness. This research was designed to determine the effect of Althaeas' root methanol extract on contractile function of rat tracheal smooth muscle. In this experimental study, 36 tracheas of a healthy and male of 18 Sprague Dawley rats were dissected in 6 groups. The effect of Althaeas' root methanol extract concentrations [0.2, 0.6, 2.6, 6.6, 14.6, 140.6 microg/ml] and epinephrine [5 microm] in presence and absence of 1microM propranolol under one gram tension based on isometric method was assayed. This assay was recorded in an organ bath containing kerebs-hancelit solution on tracheal smooth muscle contractions by KCl [60 mM] induction. Epinephrine [5 microm] alone and root methanol extract concentrations [0.6 - 140.6 microg/ml] reduced the tracheal smooth muscle contractions induced by KCl [60 mM] dose-dependently. Propranolol couldn't reduce the antispasmodic effect of root methanol extract concentrations, but it could reduce the antispasmodic effect of Epinephrine on tracheal smooth muscle contractions. Althaeas' root methanol extract inhibited the tracheal smooth muscle of rat contractions dose dependently, but it seems that beta-Adrenergic receptors are not engage in this process. Realizing the mechanism of this process can be useful in treatment of pulmonary obstructive disease
ABSTRACT
Interleukin [IL-6] is known to cause pro-and anti-inflammatory effects during different stages of inflammation. The purpose of this study was to elucidate the effects of IL-6 on hyperalgesia, edema and the changes in the spinal mu opioid receptor expression during different stages of complete Freund's adjuvant [CFA]-induced arthritis [AA] in rats. In this study, AA was induced by a single subcutaneous injection of CFA into rats' hindpaw. The rats with arthritis were divided into four groups, each consisted of three subgroups [n=6]. Anti-IL-6 was administered either daily or weekly during the 21-day study period. Spinal mu-opioid receptor [mOR] expression was detected by Western blotting. Daily treatment with an anti-IL-6 antibody significantly decreased the paw edema in the AA group compared to the control one [P=0.001], but daily and weekly anti-IL-6 administrations significantly increased the hyperalgesia in the antibody-treated group on the 14th and 21st days post-treatment [P=0.001, P=0.01, respectively]. The administration of IL-6 antibody not only increased hyperalgesia in a time-dependent manner, but also caused a significant reduction in the spinal mOR expression on the 14th and 21st days post-CFA injection [P=0.01, P=0.001, respectively]. Results can indicate the importance of a time-dependent relationship between the serum IL-6 level and hyperalgesia during the AA. Moreover, the results suggest that the stages of inflammation in AA must be considered for anti-hyperalgesic and anti-inflammatory interventions via anti-IL-6 antibody treatment
ABSTRACT
Inflammatory symptoms, hyperalgesia and edema, as a physiologic responses for stimulus can mediate via different mediators such as cytokines. Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory effects. Regarding to these and on account of the Interlukine-6 roles in hyperalgesia and edema induction, the aim of this study explained to investigation of the pre-treatment effects of Achillea santolina and Stachys athorecalyx extracts on inflammation which induced by CFA in male Wistar rats. Methanolic and defatted extractions were done on aerial parts of the both plants. Achillea santolina and Stachys athorecalyx 50, 100 and 200 mg/kg doses of extracts were selected for treatment. Results indicated that pre-treatment with defatted and methanolic extracts of S. athorecalyx significantly decrease CFA-induced hyperalgesia and edema dose-dependently. At same situation only methanolic extract of A. santolina was effective in inflammatory signs reduction. It can concluded that A. santolina and S. athorecalyx extracts can be effective candidate for pre-treatment of inflammation, but the effective substances of them are different and need to be more investiged
Subject(s)
Animals, Laboratory , Male , Stachys , Inflammation/therapy , Plant Extracts , Rats, WistarABSTRACT
Staphylococcus aureus is one of the most frequently identified pathogens in clinical laboratories and DNase is its important virulence factor. This enzyme is capable of destroying deoxyribonucleic acid [Willett etal., 1988]. There are lots of antibacterial agents that can prevent the production of this enzyme. Staphylococcus aureus can develop drug resistance to many chemical drugs so; considerable effort has been expanded by investigators in the development of herbal drugs. Black pepper, Red pepper and Zataria multiflora Boiss. are some herbal drugs that have been used in cure of infections. In this study, the alcoholic extract of Black pepper, Red pepper and Zataria multiflora Boiss. was tested for antibacterial activity against Staphylococcus aureus. Black pepper, Red pepper and Zataria multiflora Boiss. were provided from Iranian agricultural researches center.2gr of each plant powder was added tolOcc ethanol 96°. After 24hours, the crude extract was separated as an alcoholic extract and concentrated by distillation method. The antibacterial activity against Staphylococcus aureus was examined and the results showed that all the extracts were effective. The extracts that showed antimicrobial activity were later tested to determine the Minimum Inhibitory Dilution [MID] for Staphylococcus aureus. They were also effective on the inhibition of DNase activity. The inhibition against DNase activity was observed at the dilutions lower than the minimum inhibitory dilution [MID] of each extract. The results of this study showed that Black pepper, Red pepper and Zataria multiflora Boiss. extracts can play a significant role in inhibition of Staphylococcus aureus and they can inhibit release of the DNase enzyme