[Drug rash with eosinophilia and systemic cymptoms [DRESS syndrome] associated with sulfasalazine and human herpesvirus 6 infection successfully treated with steroid therapy]

We report a case of a 30-year-old man who developed a generalized erythematous skin eruption, fever, lymphadenopathy, hepatic cytolysis and eosinophilia probably due to sulfasalazine. Indirect immunofluorescence assay for Human herpesvirus-6 [HHV-6] was positive, supporting recent HHV-6 infection. The patient was successfully treated with dexamethasone. The case is reported with a review of the literature. DRESS syndrome mechanisms and management are also discussed

Pheochromacytomoe au cours dune maladie Recklinghausen

Recklinghausen Neurofibromatosis is a dominant autosomal disorder affecting one newborn over 2500 to 3500 births. Pheochromocytoma is observed at one to two% of patients affected by this disease. It can be revealed by a permanent or paroxystic hypertension, apostural hypotension or other particular manifestations: anxiety, agitation,headaches, sweating, palpitations. The diagnosis is confirmed by biochemical measurements of plasma catecholamines and mainly their urinary metabolites [metanephrine, normetanephrine, vanillymandelic acid.]. The location of pheochromocytoma, necessary to guide the surgical treatment, relies on intravenous pyelography, ultrasonography, computed tomography and mainly scintigraphy. We report a case of pheochromocytoma revealed by hypertension occured in Recklinghausen Neurofibromatosis