ABSTRACT
Helicobacter pylori is the main cause of gastritis, gastroduodenal ulcers and gastric cancer. In the past two decades, the recommended treatment for its eradication as a first-line regimen is the standard triple therapy consisting of a proton pump inhibitor [PPI], amoxicillin and clarithromycin or metronidazole. However, the effectiveness of this traditional regime, which initially was 90%, progressively declined in many parts of the world and is currently 57-73%. The aim of this study was to evaluate whether the eradication rate with triple therapy with levofloxacin is superior as first-line therapy to that with treatment using clarithromycin in the population that attended as outpatients at the Hospital of Lidice. We designed a prospective study, with two groups of patients presenting dyspeptic symptoms, from October 2010 to October 2011, who underwent upper gastrointestinal endoscopy and whose biopsies were positive for infection with H. pylori. At the end, 81 patients were included in the order of biopsy result arrival to fill the quota of each group. The first group with 42 patients underwent triple therapy with clarithromycin and the second group with 39 patients underwent therapy with levofloxacin, amoxicillin and a PPI. The patients' age ranged between 23 and 76 years, the average being 49.5. The predominant sex was female, at 72.84%. Both treatments lasted for 10 days and the patients were clinically re-evaluated 15 days after their conclusion and programmed for a second endoscopy to verify H. pylori eradication. Among the 42 patients in the control group, there were 14 eradication failures with 33.33% resistance to clarithromycin. Among the 39 patients in the experimental group, two eradication failures with 5.13% resistance to levofloxacin were observed. The x[2] value was 6.96. Treatment with levofloxacin was more effective than conventional triple therapy. Triple therapy with levofloxacin can be implemented in populations where resistance to clarithromycin has been observed
ABSTRACT
Objetivos: Correlacionar la longitud esofágica y de sus esfínteres, en pacientes adultos con enfermedad por reflujo gastroesofágico (ERGE) con síntomas típicos y atípicos. Métodos: Se realizó estudio prospectivo, de corte transversal. Se incluyeron un total de 80 pacientes con diagnóstico clínico, endoscópico y/o pHmétrico de enfermedad por reflujo gastroesofágico referidos al Laboratorio de Motilidad Digestiva del Centro Médico Docente La Trinidad en 2006-7. Se seleccionaron dos grupos: El "A" de pacientes con ERGE y síntomas típicos y el "B" con ERGE y síntomas atípicos. Se les realizó manometría esofágica, determinándose: longitud total y cuerpo esofágico; longitud y presión de los esfínteres esofágicos y presencia de hernia hiatal. Resultados: Del total de pacientes (n=80) que se incluyeron, 58 (72,5%) en el grupo A y 22 (27,5%) en el grupo B. Se encontró un EES de menor longitud en los pacientes del grupo B comparado con el del grupo A con una longitud promedio de 1,91 cm vs 2,71 cm (p= 0,0003). No se encontraron diferencias significativas en cuanto a la longitud del EEI, longitud del cuerpo esofágico. En cuanto a la longitud total esofágica, se encontró que era más corta en el grupo B que en el A, (25,32 cm. vs. 27,34 cm. p= 0,01). La presión del EEI del grupo B fue menor que la presión del mismo en el grupo A. Conclusión: La longitud del esófago total, del EES es menor en pacientes con ERGE y síntomas atípicos que en pacientes con síntomas típicos. Los pacientes con síntomas atípicos presentan una presión disminuida del EEI y una mayor frecuencia de hernia hiatal con respecto a los pacientes con ERGE y síntomas típicos.
Objective: To correlate the length of their esophageal sphincter and, in adult patients with gastroesophageal reflux disease (GERD) with symptoms typical and atypical. Methods: We conducted prospective study, cross-sectional. We included a total of 80 patients with clinical diagnosis, endoscopic and / or pHmétrico of gastroesophageal reflux disease related to laboratory Motility Digestive Centro Medico Docente La Trinidad in 2006-7. Were selected two groups: The "A" and GERD patients with typical symptoms and the "B" with atypical symptoms and GERD. They were conducted esophageal manometry, determined: total length and esophageal body; pressure and length of the esophagus and sphincters presence of hiatal hernia. Results: Of the total patients (n = 80) that were included, 58 (72.5%) in group A and 22 (27.5%) in group B. There was a minor ESS length of patients in group B compared with Group A with an average length of 1.91 cm vs. 2.71 cm (p = 0.0003) No significant differences were found on the length ERA, esophageal body length. As for the total length esophageal, was found to be shorter in group B compared with A (25.32 cm. Vs. 27.34 cms. P = 0.01). The pressure of the ERA group B was lower than the same pressure in group A. Conclusion: The total length of the esophagus, the ESS is lower in patients with atypical symptoms and GERD in patients with typical symptoms. Patients with atypical symptoms have diminished pressure ERA and a higher frequency of hiatal hernia regarding patients with typical symptoms and GERD.