ABSTRACT
OBJECTIVE: In inflammation, hyperalgesia is a common phenomenon but its mechanism has not been clarified. Recently some reports suggested substance P might be important factors for inflammatory hyperalgesia in somatic tissue. This study was performed to see whether substance P modulate the activities of uterine afferent fibers in the hypogastric nerve of the cat. METHODS: While recording the electrical activities of nerve fibers, mechanical stimuli were applied as balloon distention using balloon inserted into uterine lumen before and during substance P infusion through uterine artery. RESULTS: Substance P increased the responses to balloon distension of uterus in 14 uterine mechanoreceptive afferent fibers of 24 over 10% compared to before substance P infusion, and decreased the responses of 3. And L-703,606, the neurokinin 1 receptor antagonist failed the modulation of mechano sensitive response by substance P and reduced the spontaneous activities. CONCLUSIONS: These results suggest that substance P modulated the activities of uterine nerve fibers and their responses to mechanical stimulus. It is hypothesized that this kind of modulation of afferent nerve fibers by substance P may be important for the development of inflammatory hyperalgesia.
Subject(s)
Animals , Cats , Hyperalgesia , Inflammation , Mechanoreceptors , Nerve Fibers , Receptors, Neurokinin-1 , Substance P , Uterine Artery , UterusABSTRACT
The purpose of this study was to investigate pregnancy, abortion and delivery rates among Korean teenagers. The subjects of this study were 11,433 teenagers aged 13-19 year in Seoul, Pusan, Taegu, Kwangju, Insheon, Taejeon and Ansan, Korea. Data were collected from Feb. 1994 to May 1995, 16 months, by schoolnurses or the researchers. The results showed pregnancy rate was 7.2 per 1,000 teenagers, the abortion rate was 4.3 per 1,000 teenagers, and delivery rate was 1.2 per 1,000 teenagers. In the pregnancy experience, the main factors related to teenage pregnancy were love or marriage engagement. In the abortion experience, 53.9% of teenagers had more than two abortion experiences, 38.1% midtrimester abortion, 22% complications after abortion. In the delivery experience, 64.3% of teenagers delivered with no prenatal care and 42.9% had a delay in realizing they were pregnant. Fifty percent were delivered by non-professionals in non-medical institutions.
Subject(s)
Adolescent , Female , Humans , Pregnancy , Abortion, Induced , Birth Rate , Korea , Love , Marriage , Pregnancy in Adolescence , Pregnancy Rate , Pregnancy Trimester, Second , Prenatal Care , SeoulABSTRACT
This study was performed to investigate the effects of nitrous oxide-narcotic anesthesia (Nitrous oxide-pethidine HCI-muscle relaxant) and surgery on plasma aldosterons level in surgical patients and the aldosterone level in plasma was measured by the Abbott Laboratorie's Aldosterone RIA Kit. Average body weights and ages of subjects were 58.1+/-6.45(kg) and 43.8+/-11.55(yrs) respectively. Mean control aldosterone level in plasma was 121.3+/-58.66I(pg/ml) (mean +/- SE) but it gradually rose during anesthesia and surgery. The mean plasma aldosterone level rose to 232.7+/-40.06(pg/ml) (p<0.005) at 90 minutes after the start of surgery, and therefore, it was a significantly higher value than that of the control.
Subject(s)
Humans , Aldosterone , Anesthesia , Body Weight , PlasmaABSTRACT
The problem of hepatotoxicity of clinically employed halogenated inhalation anesthetics has major implications for the practice of anesthesiology. Because of emerging disadvantages with all the available anesthetics, chemists continue to search for better compounds. In 1963 Terrel synthesized enflurane and many anesthesiologist used it, hoping to avoid the disadvantage of halothane. This study was undertaken to investigate the advantage of enflurane as compared to the disadvantege of halothane, by comparing of pre- and post- operative liver functions of 16 cases of halothane use and 16 cases of enflurane use. in this study, all cases physical status were all ASA class 1, and excluded patients who had any liver disease, jaundice, previous experience of halothane or enflurane anesthesis, and who had not been transfused during this study. The result of this study which compared pre-operative and post-operative liver function tests disclosed statistically significant change in SGOT(p<0.02). On table lll the comparison of liver function tests between halothane and enflurane disclosed significant difference and that enflurane in less hepatotoxic than halothane. Considering the allergic or the intermediate by-product theory of the mechanism of halethane hepatoxicity, it is desirable to avoid repeating the use of halothane in the near future. Thus, it seems to be safer to use enflurane instead of halothane.
Subject(s)
Humans , Anesthesia , Anesthesiology , Anesthetics , Anesthetics, Inhalation , Enflurane , Halothane , Hope , Jaundice , Liver Diseases , Liver Function Tests , LiverABSTRACT
This is taecase report of a 64 year old male patient with the chief complaint of esophagial vahix bjeeding, who has been scheduled for emergency sever hypoalbuminemia, and abnormal liver function test. Anesthesia was induced with nitrous oxide, Innovar, morphine sulfate, pancuronium bromide and Valium. The long operation of 3 hours required transfusions of 5 pints banked bloods without any and difficulty. Anesthesia was reversed with Nsrcan, neostigmain and Atropine. In the recovery room, the patient's ventilation was satisfactory but he did not recover from deep coma until 5 hours after surgery. After repeated injection of Narcan intramuscularly the patient awoke from his deep asleep at midnight without any delayed sequelae.
Subject(s)
Humans , Male , Middle Aged , Anesthesia , Atropine , Balanced Anesthesia , Coma , Diazepam , Emergencies , Hypoalbuminemia , Liver Cirrhosis , Liver Function Tests , Liver , Morphine , Naloxone , Nitrous Oxide , Pancuronium , Recovery Room , VentilationABSTRACT
This study was undertaken to investigate the effect of premedicants, diazepam and atropine sulfate in twenty surgical patients by measuring the Human Plasma Renin Acitivty. RENIN. RIA(Radioimmunoassay K for Angiotensin I) was utilized and the renin activity was expressed as the release of angiotenain I, ng. per ml. of plasma per hour. The sex ratio between male and female patients was 11:9, mean age 38,95+/-13.16 and average body weight 55.5+/-8.20kg. The value of the human plasma renin activity before administration of premedicants was 2.05+/-0.95ng/ml/hr. and at 60 minutes after administration of premedicante it was 2.21+/-0.82ng/ml/hr., and it's result was within normal limits. Consequently there was no significant change statistically in human plasma renin activity after one hour of premedications.