ABSTRACT
To our knowledge, only one case of vaginal cavernous hemangioma in pregnancy has been reported all over the world and there is no report in Korea. The authors have experienced one case of vaginal cavernous hemangioma in pregnancy and report our case with a brief review of literature.
Subject(s)
Pregnancy , Hemangioma, Cavernous , Korea , VaginaABSTRACT
OBJECTIVE: p63 is a member of the p53 gene family. The main aim of this study was to compare p63 and p53 expression in precancerous lesions and invasive squamous cell carcinoma of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade squamous intraepithelial lesion (22 cases), high-grade squamous intraepithelial lesion (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of p63, p53 and topoisomerase II-alpha. RESULTS: p63 was statistically significant higher immunoreactivity according to progression of uterine cervical squamous lesions, but p53 was not significant. No statistical correlation was found between p63 and p53. Topoisomerase II-alpha index was statistically significant higher according to increase of p63 expression. CONCLUSION: These findings suggest that the expression of p63 protein may play a roles in progression and proliferative activities of the uterine cervical squamous lesions.
Subject(s)
Female , Humans , Carcinoma, Squamous Cell , Cervix Uteri , Genes, p53 , ImmunohistochemistryABSTRACT
OBJECTIVE: The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.