ABSTRACT
Most trauma induced fistulas are direct communications between the intracavernous carotid artery and the cavernous sinus. Theses abnormal communications are characterized by high pressure, high blood flow and a clinically obvious constellation of symptoms and signs. We here in report a patient with traumatic carotid cavernous sinus fistula(CCSF). who developed central retinal vein occlusion(CRVO) during detachable balloon embolization. The mechanism of CRVO occurring during detachable balloon embolization. The mechanism of CRVO occurring during detachable ballon embolization for CCSF was discussed. We report this case with the review of previous reports.
Subject(s)
Humans , Balloon Occlusion , Carotid Arteries , Carotid-Cavernous Sinus Fistula , Cavernous Sinus , Fistula , Retinal VeinABSTRACT
Mitomycin C is an antibiotic isolated from the broth of Streptomyces caespitosus which has been used as the adjunctive drug to reduce the fibroblast proliferation. Holmium laser sclerostomy can minimize conjunctival damage. We examined pharmacokinetics of mitomycin C following topical administration. Holmium laser sclerostomy was performed on one eye of each 15 rabbits and the other eye was served as a control. Next day, mitomycin C solution(0.4mg/ml) was administered by topical drops in both eyes of each rabbit. The concentrations of mitomycin C in the aqueous and the vitreous compartments of operated and control eyes were determined by HPLC at 0.5, 1, 2, 3, 6 hours after topical administration. The peak aqueous concentration was 0.07 microgram/ml in operated eyes and 0.06 microgram/ml in control eyes. The peak vitreous concentration was 0.10 microgram/ml in operated eyes and 0.09 microgram/ml in control eyes. The levels of detected mitomycin C at all time intervals were higher than the IC50(0.002 microgram/ml) for the inhibition of conjunctival fibroblast proliferation. These results suggest that topical mitomycin C easily crosses the intact and minimally damaged conjunctiva and therefore increases the success rate of Holmium laser sclerostomy.
Subject(s)
Rabbits , Administration, Topical , Chromatography, High Pressure Liquid , Conjunctiva , Fibroblasts , Holmium , Lasers, Solid-State , Mitomycin , Pharmacokinetics , Sclerostomy , StreptomycesABSTRACT
Hydroa vacciniforme is a rare, chronic disease that is characterized by recur rent erythema and vesicles on uncovered skin within several days of sun exposure and is followed by healing with scarring. We have experienced a case of hydroa vacciniforme which involved the cornea, and we performed a penetra ting keratoplasty with a good result. We report this case with a review of the literature.