ABSTRACT
Kaposi sarcoma (KS) is a multicentric proliferative vascular tumor involving the skin and other organs. Human herpesvirus 8 (HHV-8) has been detected in KS lesions and is considered the putative causative agent of KS. The relationship between chronic renal failure, HHV-8, and KS is not clear. KS appears to develop in association with renal transplantation, but is unlikely with dialysis, and there have been few reports on this. Here, we report the case of a 51-year-old man, who underwent peritoneal dialysis to treat chronic renal failure, and presented with multiple brownish plaques on his soles. On histopathological examination, abnormally proliferated vessels, vascular slits, and spindle-shaped cells were seen in the dermis. Immunohistochemical staining for HHV-8 was positive. This case is another example in which factors other than immunosuppression contributed to the development of KS, due to activation of HHV-8.
Subject(s)
Humans , Middle Aged , Dermis , Dialysis , Herpesvirus 8, Human , Immunosuppression Therapy , Kidney Failure, Chronic , Kidney Transplantation , Peritoneal Dialysis , Sarcoma, Kaposi , SkinABSTRACT
Steatocystoma multiplex (SM) is an uncommon disorder of the pilosebaceous unit characterized by the development of numerous sebum-containing dermal cysts which rarely involves the scalp. Here, we report a case of a 50-year-old man with multiple cystic nodules and alopecic patches on his scalp. On histopathological examination, the folded cyst was found to be lined by stratified squamous epithelium, while flattened sebaceous gland cells were identified in the cystic wall. Pigment casts were present in the hair papillae and perifollicular regions, suggesting trichotillomania as a possible cause of the observed alopecia. This case appears to represent an unusual clinical manifestation of SM.
Subject(s)
Humans , Middle Aged , Alopecia , Epithelium , Hair , Scalp , Sebaceous Glands , Steatocystoma Multiplex , TrichotillomaniaABSTRACT
BACKGROUND: Superficial fungal infections are common dermatologic disorders, and causative organisms include dermatophytes, yeasts, and nondermatophyte molds. The data about incidence of fungal pathogens can be used to predict increase in antifungal resistasnce and the adequacy of our current pharmacologic repertoire, and provide insight into future developments. OBJECTIVES: This study aimed to identify epidemiologic features and the various organisms from clinically suspected cases of superficial fungal infection. METHODS: A total 11,656 specimens were collected from clinically suspected tinea corporis, tinea cruris, tinea capitis, tinea faciei, tinea manuum, tinea pedis, and finger and toe onychomycosis among patients of Dermatologic clinic of Asan Medical Center from 1998 through 2002. Clinical and culture studies on these cases were performed. However, attemps to establish the causative organism were not done. RESULTS: The incidence of clinically suspected cases was highest in the fifth to sixth decades. The ratio of male to female was 1.09:1. The incidence of toenail was highest, followed by feet, fingernail, trunk and extremeties, groin, scalp, and face. The positive rate of KOH examination was 49.2% and that of culture was 51.4%. Dermatophytes was the most commoly isolated fungal organisms except fingernail onychomycosis. Trichophyton rubrum was the most prevalent fungal pathogen among them. High incidence of Candida species and Trichosporon species was documented in hands, feet and nails. CONCLUSION: Consideration of the current epidemiologic, clinical and mycologic features in the cutaneous fungal infections is of key importance to investigational efforts, diagnosis, and treatment.
Subject(s)
Female , Humans , Male , Arthrodermataceae , Candida , Diagnosis , Fingers , Foot , Fungi , Groin , Hand , Incidence , Nails , Onychomycosis , Scalp , Tinea , Tinea Capitis , Tinea Pedis , Toes , Trichophyton , Trichosporon , YeastsABSTRACT
"Black dot" tinea capitis is a clinical form of tinea capitis, which is a dermatophytosis of the scalp and associated hair. It is caused by the anthropophilic endothrix organisms. We report a case of black dot tinea capitis caused by Trichophyton (T.) tonsurans in an 18-year-old woman who is a judoist in the college. She had suffered from a diffuse hair loss involving nearly entire scalp hair for 1 year. The scalp lesion showed diffuse multiple black dots with minimal inflammatory sign or scales. KOH examination revealed arthroconidia of endothrix pattern. On mycological studies, T. tonsusrans was identified. She was treated with oral itraconazole pulse therapy (2 cycles) and ketoconazole shampoo.