The Relationship Between Parameters Measured by Optical Coherence Tomography and Visual Field Indices

PURPOSE: To evaluate the diagnostic ability of optic disc topographic parameters and the retinal nerve fiber layer (RNFL) thickness parameter measured by optical coherence tomography (OCT) and to determine the association of these structural parameters with visual field indices. METHODS: Fifty-six glaucomatous eyes and 65 healthy control eyes were enrolled in this retrospective cross-sectional study. Each subject had a 24-2 full threshold test on a Humphrey visual field analyzer and an optical coherence tomographic evaluation. The parameters from the fast RNFL thickness algorithm and the fast optic disc algorithm were analyzed by an ROC curve, and we sought to determine the association of these parameters with visual field indices by linear and logarithmic regression. RESULTS: The area under the receiver operating characteristic curve (AUROC) value of the fast optic disc algorithm parameters ranged from 0.78 to 0.79 and that of the fast RNFL thickness algorithm parameters ranged from 0.74 to 0.81. The associations between the parameters from the fast optic disc algorithm and from the fast RNFL thickness algorithm with visual field indices were statistically significant (P<0.001). CONCLUSIONS: The fast optic disc algorithm and the fast RNFL algorithm revealed comparable diagnostic ability in discriminating glaucoma and significant associations with visual field indices.

Diagnostic Ability of Scanning Laser Polarimetry with Enhanced Corneal Compensation in the Eye with Typical and Atypical Retadation Pattern

PURPOSE: To investigate the relationship between the SLP-VCC parameters and the SLP-ECC parameters in the eyes with typical retardation pattern (TRP) and atypical retardation pattern (ARP), and the sensitivities and specificities of the SLP-VCC parameters and the SLP-ECC parameters in the eye with TRP and ARP. METHODS: In this prospective study, 72 eyes with TRP images (30 glaucomatous and 42 normal eyes) and 53 eyes with ARP images (28 glaucomatous and 25 normal eyes) were recruited. For each group, we analyzed relationship between each parameters of GDx-VCC and GDx-ECC and the diagnostic ability of GDx-ECC by using the ROC curve. RESULTS: In the eyes with TRP, TSNIT average was significantly lower by GDx-ECC than GDx-VCC in the control group. Inferior average was significantly higher by GDx-ECC than GDx-VCC in both glaucomatous and normal group. TSNIT standard deviation was significantly higher by GDx-ECC than GDx-VCC in both groups. NFI was significantly lower by GDx-ECC than GDx-VCC in both groups. TSS (typical scan score) was significantly higher by GDx-ECC than GDx-VCC in both groups. In the eyes with ARP, TSNIT average was significantly lower by GDx-ECC than GDx-VCC in both groups. Superior and Inferior average was not different between GDx-ECC and GDx-VCC. TSNIT standard deviation was significantly higher by GDx-ECC than GDx-VCC in both groups. NFI was not different between groups. TSS was significantly higher by GDx-ECC than GDx-VCC in both groups. Comparison of ROC curve for the SLP parameters revealed no difference between VCC and ECC. TSNIT standard deviation, however, showed relatively high value in GDx-ECC compared with GDx-VCC. CONCLUSIONS: GDx-ECC has comparable diagnostic ability in discriminating glaucomatous and normal eyes with GDx-VCC and TSNIT standard deviation by the GDx-ECC algorithm could be a useful parameter in discriminating glaucomatous and normal eyes.

Ultrasonographic Findings in Infectious Endophthalmitis

PURPOSE: To investigate the correlation between ultrasonographic findings and clinical features of infectious endophthalmitis. METHODS: We analyzed ultrasonographic findings of 38 eyes of 36 patients who had been diagnosed as having infectious endophthalmitis with various etiologies. The correlation between ultrasonographic findings and clinical features such as initial and final visual acuities were studied. RESULTS: Fourteen eyes were diagnosed with endogenous endophthalmitis and 11 eyes with postoperative endophthalmitis. Posterior vitreous opacity in the endophthalmitis secondary to keratitis was more severe and subhyaloid opacity in the traumatic endophthalmitis was less severe. Coagulase negative staphylococcus was the most common causative agents. Subhyaloid opacity in the eyes where cultures were not performed, was more severe than in those where coagulase negative staphylococcus was identified. Among the various ultrasonographic findings only the degree of the posterior vitreous opacity was correlated with the initial visual acuity, and none of the findings was significantly related with the final visual acuity. Treatment modalities included intravitreal antibiotics injections in 13 eyes, immediate vitrectomies and antibiotics injection in 6 eyes, conversion to vitrectomy after antibiotics injection in 17 eyes, and eviscerations in 2 eyes. The grades of posterior vitreous opacity of the patients with conversion to vitrectomy after antibiotics injection were lower than those of the other groups. CONCLUSIONS: Ultrasonographic findings might be a useful factors in the diagnosis and the determination of treatment modality and may therefore be helpful in the prognosis of patients with suspected infectious endophthalmitis.