Laboratory animal allergy in laboratory animal workers / 천식및알레르기

BACKGROUND: Laboratory animal workers who are in regular contact with furred animals commonly develop laboratory animal allergy (LAA). LAA is one of the most common occupational allergic diseases. OBJECTIVES: This study was performed to estimate the prevalence of sensitization and symptoms of LAA, and to determine important host factors for the development of LAA. METHOD: Sixteen subjects with laboratory animal workers in one medical research center were enrolled in this study. They responded to a questionnaire about work-related symptoms and underwent allergy skin prick test to common inhalant and laboratory animal allergens. RESULTS: The prevalence of sensitization to laboratory animal allergens was 18.8%, and all sensitized workers were atopic (positive skin reactivity to one or more common inhalant allergens). Prevalence rate of allergy symptoms caused by working with laboratory animals was 31.3%. Positive skin prick responses to dog or cat allergens were highly associated with specific sensitization to laboratory animal allergens, and positive skin responses to laboratory animal allergens were associated with laboratory allergy symptoms. Among sixteen subjects, we found out one case of occupational asthma due to mouse allergy and also reported the case here. CONCLUSION: Some laboratory animal workers showed sensitization to laboratory animal allergens and had allergic symptoms attributed to contact with laboratory animals. Atopy, especially atopy to dogs or cats may be an important host factor for the development of LAA.

Fracture of the Ipsilateral Femur after Total Hip Arthroplasty / 대한정형외과학회잡지

PURPOSE: Although considered uncommon, periprosthetic fracture of the femur after hip arthroplasty is a serious complication that can be difficult to treat. Authors analyzed the types of fracture and modality of treatment. MATERIALS AND METHODS: Between Jan. 1983 and Dec. 1997, 17 cases of postoperative periprosthetic fractures had been treated at our hospital. These cases were followed up for an average of 58 (13-123) months. The fractures were classified according to Duncan and Masri classification. Three cases of type A, and 6 cases of type B1, 3 cases of type B2, 3 cases of type B3 and 2 cases of type C. The 3 cases of type A and 2 cases oftype B1 were conservative treatments. The 4 cases of type B1 were treated with open reduction and internal fixation with bone graft. The 3 cases of type B2 and 3 cases in type B3 were treated with long stem revision. The 2 cases of type C were treated with open reduction and internal fixation with bone graft. RESULTS: Bony union happened in all cases. The results according to Beals and Tower criteria were excellent in 12 cases, good in 3 cases and poor in 2 cases. CONCLUSIONS: The most frequent cause of periprostic fracture was trauma and other causes were loosening and osteolysis. Proper treatment method of periprosthetic fracture were important for stability of femoral stem