ABSTRACT
Pityriasis lichenoides et varioliformis acuta is a cutaneous disease of unknown origin characterized by an acute polymorphous eruption which heals with superficial scarring and pigmentation. It occurs mainly in young adults and less commonly in children. Although various types of therapy have been proposed for pityriasis lichenoides, including systemic steroids, tetracycline, methotrexate, sulfones, an UV radiation, there is no definitive treatment and there is few studies of appropriate, efficacious therapy in children. We report a case of pityriasis lichenoides et varioliformis acuta in children treated with roxithromycin.
Subject(s)
Child , Humans , Young Adult , Cicatrix , Methotrexate , Pigmentation , Pityriasis Lichenoides , Pityriasis , Roxithromycin , Steroids , Sulfones , TetracyclineABSTRACT
Pityriasis lichenoides et varioliformis acuta is a cutaneous disease of unknown origin characterized by an acute polymorphous eruption which heals with superficial scarring and pigmentation. It occurs mainly in young adults and less commonly in children. Although various types of therapy have been proposed for pityriasis lichenoides, including systemic steroids, tetracycline, methotrexate, sulfones, an UV radiation, there is no definitive treatment and there is few studies of appropriate, efficacious therapy in children. We report a case of pityriasis lichenoides et varioliformis acuta in children treated with roxithromycin.
Subject(s)
Child , Humans , Young Adult , Cicatrix , Methotrexate , Pigmentation , Pityriasis Lichenoides , Pityriasis , Roxithromycin , Steroids , Sulfones , TetracyclineABSTRACT
Actinic granuloma presents in chronically sun-damaged skin as normally colored to erythematous papules that coalesce to form centrifugally enlarging annular patterns. Histologically, a granulomatous infiltrate of giant cells and histiocytes is seen to be intimately related to the presence of elastotic fibers in the upper dermis. We report a typical case of actinic granuloma that developed on the V-area of anterior chest in a 59-year-old male.
Subject(s)
Humans , Male , Middle Aged , Actins , Dermis , Giant Cells , Granuloma , Histiocytes , Skin , ThoraxABSTRACT
Actinic granuloma presents in chronically sun-damaged skin as normally colored to erythematous papules that coalesce to form centrifugally enlarging annular patterns. Histologically, a granulomatous infiltrate of giant cells and histiocytes is seen to be intimately related to the presence of elastotic fibers in the upper dermis. We report a typical case of actinic granuloma that developed on the V-area of anterior chest in a 59-year-old male.
Subject(s)
Humans , Male , Middle Aged , Actins , Dermis , Giant Cells , Granuloma , Histiocytes , Skin , ThoraxABSTRACT
Melkersson-Rosenthal syndrome(MRS) is a rare neuro-muco-cutaneous disease of unknown origin. The classic triad of this clinically defined entity consists of orofacial swelling, facial nerve palsy, and lingua plitica. MRS may occur as a complete triad of symptoms or a combination of any features of the classic triad, termed monosymptomatic and oligosymptomatic forms. The complete triad has been reported to occur in only 10% to 20% in different series. Because of the rarity of reported cases in Korea, we report a case of complete form of MRS, in which clofazimine showed a partial response.
Subject(s)
Clofazimine , Facial Nerve , Korea , Melkersson-Rosenthal Syndrome , ParalysisABSTRACT
BACKGROUND: Optimal management of cutaneous varicella-zoster virus(VZV) and herpes simplex virus(HSV) infections requires rapid and accurate diagnostic method. The Tzanck test is a simple, inexpensive and rapid method, but it shows relatively low sensitivity and cannot distinguish VZV and HSV. The viral culture is the reference method, but it is time-consuming and needs cell culture facilities. Direct immunofluorescence(DIF) method has been known to be rapid and sensitive, but it has not been widely used in Korea. OBJECTIVE: We compared the usefulness of DIF method to Tzanck smear in patients with VZV and HSV infections. METHODS: Smears were collected from the base of fresh vesicular lesions, from a total of 134 patients clinically suspected of having VZV or HSV infections. The two wells of IF slide were stained with FITC-conjugated VZV-specific and HSV-specific monoclonal antibody each. Apple-green fluorescence of cytoplasm was considered positive for VZV or HSV. Glass slide smears were made for Tzanck test and stained with Wright stain. Giant cells with enlarged nucleus were considered positive. RESULTS: Among the 107 patients suspected of having VZV infection, positive rates of DIF method and Tzanck test were 91.6% and 76.6%, respectively. The positive rates of HSV in 27 patients suspected of having HSV infection, were 92.6% and 74.1%, respectively. The positive rates of DIF method were higher than that of the Tzanck test in both VZV and HSV infections. CONCLUSION: The DIF method is a more sensitive and relatively rapid method for the diagnosis of cutaneous VZV and HSV infections.
Subject(s)
Humans , Cell Culture Techniques , Cytoplasm , Diagnosis , Fluorescence , Fluorescent Antibody Technique, Direct , Giant Cells , Glass , Herpes Simplex , Herpesvirus 3, Human , Korea , SimplexvirusABSTRACT
BACKGROUND: Optimal management of cutaneous varicella-zoster virus(VZV) and herpes simplex virus(HSV) infections requires rapid and accurate diagnostic method. The Tzanck test is a simple, inexpensive and rapid method, but it shows relatively low sensitivity and cannot distinguish VZV and HSV. The viral culture is the reference method, but it is time-consuming and needs cell culture facilities. Direct immunofluorescence(DIF) method has been known to be rapid and sensitive, but it has not been widely used in Korea. OBJECTIVE: We compared the usefulness of DIF method to Tzanck smear in patients with VZV and HSV infections. METHODS: Smears were collected from the base of fresh vesicular lesions, from a total of 134 patients clinically suspected of having VZV or HSV infections. The two wells of IF slide were stained with FITC-conjugated VZV-specific and HSV-specific monoclonal antibody each. Apple-green fluorescence of cytoplasm was considered positive for VZV or HSV. Glass slide smears were made for Tzanck test and stained with Wright stain. Giant cells with enlarged nucleus were considered positive. RESULTS: Among the 107 patients suspected of having VZV infection, positive rates of DIF method and Tzanck test were 91.6% and 76.6%, respectively. The positive rates of HSV in 27 patients suspected of having HSV infection, were 92.6% and 74.1%, respectively. The positive rates of DIF method were higher than that of the Tzanck test in both VZV and HSV infections. CONCLUSION: The DIF method is a more sensitive and relatively rapid method for the diagnosis of cutaneous VZV and HSV infections.
Subject(s)
Humans , Cell Culture Techniques , Cytoplasm , Diagnosis , Fluorescence , Fluorescent Antibody Technique, Direct , Giant Cells , Glass , Herpes Simplex , Herpesvirus 3, Human , Korea , SimplexvirusABSTRACT
Pigmented lesions of palmar and plantar skin may cause diagnostic problems, because some features of benign lesions in these sites may raise the suspicion of melanoma if considered alone. Transepidermal elimlnation is a mechanism by which a substance is eliminated through the epidermis, and it is apt to be confused with a feature of melanoma that tumor cells are located at all layers of the epidermis. We report a case of transepidermal elimination of nevus cells in acral letiginous nevus which needs a differential dignosis of melanoma.
Subject(s)
Epidermis , Melanoma , Nevus , SkinABSTRACT
Lichen aureus is a variant of pigmented purpuric lichenoid dermatitis. The skin lesions usually appear asymptomatic rusty, copper, or orange colored roundish lichenoid erythematous-purpuric papules and patches on the lower extremities. Histologically, the epidermis shows minimal changes, with a dense lymphohistiocytic infiltrate observed in the superficial derrnis, typically distributed in a band-like fashion. The typical lesion is a single patch localized on the lower extremity. We report a rare case of segmental lichen aureus localized on the right lower extremity.
Subject(s)
Citrus sinensis , Copper , Dermatitis , Epidermis , Lichens , Lower Extremity , SkinABSTRACT
Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible interindividual and interethnic variation. However, no pharmacogenetic information on CYP2E1 polymorphism has been available from a Korean population. The aim of this study was to explore the pharmacogenetics of CYP2E1 polymorphism in a native Koreans after an oral 400 mg dose of chlorzoxazone administered to 128 subjects. Urine samples were collected during the subsequent 8-hour period and urinary concentrations of chlorzoxazone and 6-hydroxychlorzoxazone were determined by a high performance liquid chromatography with an ultraviolet detector. The limit of detection in the samples was found to be 0.5 mug/ml. The mean value of the 6-hydroxychlorzoxazone excreted in 8 hr urine expressed as the percentage was 48.2 13.8%. The frequency distribution of percentage of the administered dose excreted as the 6-hydroxy metabolite was unimodally distributed in the subjects studied. However, the values showed wide (7-fold) interindividual difference, ranged from 11.6% to 79.8% of the dose of chlorzoxazone. Thus, it was considered that the pharmacogenetic characteristics of CYP2E1 in a Korean population did not-represent multimodal distribution in the 6-hydroxychlorzoxazone excreted in 8-hr urine expressed as the percentage. And the activity of the CYP2E1 in a Korean population seemed to be less compared with that of the Caucasian subjects.