ABSTRACT
The aim of this study was to describe our results and investigate the survival of below-18-year-old patients undergoing LRDLT and the factors affecting this. Living Related Donor Liver Transplantation [LRDLT] has become a good option to provide suitable grafts for children with liver diseases. Using this method, children who have no chance for life can live a much longer life. The present study is a historical cohort study carried on 191 patients below-18-years-old who had undergone LRDLT for the first time in the Namazi hospital liver transplantation center. Survival rate of the patients was assessed using Kaplan-Meier method. The effect of factors related to the recipients, donors, and the transplantation process on the patients' survival was also investigated. 1, 3, 5 and 11-year survival of patients was 71%, 66%, 65%, and 65%, respectively. In the univariate analysis, age, weight at transplantation, PELD/MELD score, existence of post-transplant complications were found to be effective factors on the patients' survival. In the multivariate analysis, weight at transplantation, PELD/MELD score, and existence of post-transplant complications were the prognostic variables. LRDLT is now well established with satisfactory results in our center. Although the survival rate of the patients is lower than the survival rate reported in other studies, but the survival of the patients who had survived 1 month after the transplantation was comparable to other studies
ABSTRACT
Renal transplantation is the best option for treatment of the end-stage renal diseases and has more advantages than dialysis. The objective of this study was to determine the ten-year graft survival rate of renal transplantation and its contributing factors among a group of Iranian patients aged 18 years or younger. In a retrospective cohort we aimed to study the ten-year graft survival rate of renal transplantation and its contributing factors among pediatric patients who have been transplanted from March 1999 to March 2009 in Shiraz Namazi Hospital Transplantation Center, southern Iran. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regression model to determine hazard ratios and to model variables affecting survival. The 1, 3, 5, 7 and 10 year-graft survival rates were 96.8, 88.8, 82.8, 78.1, 78.1 percent, respectively. Cox regression model revealed that the duration of hospitalization was one of the important factors in graft survival rate in renal transplantation. In this study, the 10 year-graft survival rate for pediatric renal transplantation was 78.1%. Graft survival was significantly related to hospital stay after the operation. Donor source, cold ischemia time, immunosuppressive drugs regimen, time to diuresis, and cause of ESRD did not influence the survival rate.
ABSTRACT
Childhood cancers are very rare diseases and accounting for about one percent of all cancers, also it is one of the main causes of death among children. The aim of this paper was to ascertain of childhood cancers epidemiology in Fars province. In this epidemiological study that Fars province cancer registry was used, frequency distribution of childhood cancers in less than 19 year old in 2001up to 2008 was evaluated and incidence rates were calculated per 1000,000 people a year. Data were analyzed by running SPSS software, version 16 [SPSS Inc., Chicago, IL] and M.S. Excel version 2007. Out of 1610 registered new cancer cases that were resident of Fars province, blood cell cancers were most common type of cancers. 57% of cases were male and 15-18 year old age group in comparison to other groups has been the most frequent [30.7%]. The mean age of cases at diagnose time was 10.3 years old. Over in eight years period, lowest and highest age standardized incidence rate was 64 [year 2001] and 235 [year 2006] cases per every one million person, respectively. Based on this paper's results, and despite of our prospect, childhood cancer incidence rate in less than 19 year age in Fars province was similar to developed countries
ABSTRACT
Kidney transplantation is the treatment of choice for end stage renal disease that restores the patients' quality of life and reduces the morbidity and mortality rates induced by renal failure and its complications. The aim of this study is to determine the ten-year graft cumulative survival rate of renal transplantation in patients who have been transplanted from March 1999 to March 2009 in Shiraz Nemazi Hospital Transplantation Center, Iran. This is a retrospective cohort study designed to determine the organ survival rate after kidney transplantation and its relationship with age and gender of recipients and donors, during a period of 10 years [March 1999 to March 2009] in 1356 patients, Shiraz transplant center, Namazi hospital, Shiraz, Iran. Kaplan-Meier method was used to determine the graft cumulative survival rate and log-rank test was used to assessment difference between survival curves in subgroups. Mean follow-up period was 47.23 +/- 33.3 months. Ten years graft cumulative survival rate of kidney transplantation calculated by Kaplan-Meier method was 85.8% [95% CI=85.78 - 85.81]. Age of recipients and donors were showed significant relationship with survival rate of renal allograft. Renal transplantation is one of the important therapeutic strategies in end stage renal disease, and chosen the appropriate donor, can improve the graft cumulative survival rate. The based on this study results, we found no significant relationship between donor and recipients' sex with graft cumulative survival rate, but the relationship between age of donor and recipient and graft cumulative survival rate were significant