A Case of Sebaceous Gland Carcinoma of the Eyelid with Huge Mass / 대한피부과학회지

We report a case of sebaceous gland carcinoma occuring in a 55 year-old woman, which showed huge ulcerated tumor mass measuring 6X7 cm in size and orbital invasion on left lower eyelid without any evidence of metastases. She was treated with wide excision of the lesion and exenteration of the eyeball, and then grafted with skin and muscle. We obtained good result with surgical treatment until 8 months observation after surgical operation.

A Case of Sebaceous Gland Carcinoma of the Eyelid with Huge Mass / 대한피부과학회지

We report a case of sebaceous gland carcinoma occuring in a 55 year-old woman, which showed huge ulcerated tumor mass measuring 6X7 cm in size and orbital invasion on left lower eyelid without any evidence of metastases. She was treated with wide excision of the lesion and exenteration of the eyeball, and then grafted with skin and muscle. We obtained good result with surgical treatment until 8 months observation after surgical operation.

A Malignant Melanoma Showing Excellent Effect with Combination of DTIC Chemotherapy and BCG Immunotherapy / 대한피부과학회지

We report a case of malignant melanorna, which showed dramatic effect by combination therapy of DTIC and BCG immunotherpy. The case was s 56-year-old female patient who had an asymptomatic dark brown colored walunt sized protruding tumor with ulceration of the medial aspect of lower one third of right leg for 1 year and palpable masses over the right popliteal fossa and inguinal area. Histologic fingings showed cellular mass composed of epithelioid cells with atypical nucleus, occasionally mitotic figure and numerous melanin granules scattered in the epidermo-dermal junction and papillary or reticular dermis. The mass was diagnosed nodular malignant melanoma which showed Clark level W with metastasis in 4th thoracic vertebra and lymph node. After surgical remove of the primary lesion, chemo-immunotherapy with combined DTIC and BCG was tried, and all the lesion were completely dissppeared. No evidence of recurrence either in primsry focus or other sites was observed up to one year and eight months.

Immunofluorescent Studies of Various Cutaneous Vasculitides / 대한피부과학회지

Vascular tissue presumed to be the most sensitive target tissue of the immune and toxic reactions. Most of the vasculitides can be directly or indirectly associated with immunopathogenic rnechanisms. In this regards, the purpose of the study is to understand imrnunopathogenic mechanism of various cutaneous vasculitides by comparing their immunopathologic patterns. Imrnunopathologic studies were carried out on the blood vessel of various skin diseases by means of the direct immunofluorescent technique using FITC conjugated rabbit antihurnan IgG, IgA, IgM, C3 C1q, C4 and fibrinogen)(F). The results obtained were as follows : 16 patients with leukocytoclastic vasculitis out of 19 showed deposition of irnmune complex in the small upper dermal vessels and had positive reaction for F, 8 for IgA, 5 for C3 and 2 for IgM. Of the 6 patients with chronic pigmented purpura studied, 2 had IgM, 3 had Ca and all of these had F in small upper or middle dermal vessels. Immunopathologic patterns of livedo vasculitis were similar to those of chronic pigmented purpurs, except mainly affected in upper dermis. Nodular vasculitis and Behqets syndrome had deposits of F, C and IgM in medium or large vessels of the middle or lower dermis. Simultaneously, Cs in 2 patients with nodular vnsculitis and IgM in one patient with Behqets syndrorne were also noted along the basement mernbrane zone. In a patient with pityriasis lichenoides et varioliformis acuta, IgM and F were noted on the samll upper dermal vessels. With these results, the immune complex mechanism could be closly related the pathogenesis of most of cutaneous vasculitis. And various clinical manifestations or expression of vasculitis appear to be dependent upon 1) type of imrnune reaction, 2) size of blood vessels, 3) location and depth of blood vessels, 4) extend of affected areas and 5) involvement of other organs.

Clinical Study on Relation Between Herpes Zoster and Underlying Diseases / 대한피부과학회지

This study was designed to observe more closely about clinical course, complication, predilection site of skin eruption and associated diseases with herpes zoster. Total 122 cases of herpes zoster were prospectively observed from April 1986 to July 1987. The results obtained were as follows : 1. The ineidence of herpes zoster versus the total number of outpatients was 20.6%. There was no difference in sex ratio of male(52.5%) to female(47.5%). 2. Herpes zoster was observed most frequently in the 50-59 year age group (25.4%). 3. There were no marked monthly or seasonal difference in herpes zoster without an explosive outbreak or an epidemic cycle. 4, We found that 68 cases(55.7%) were associated with underlying diseases : the most common disease was hypertension(23 cases), the next one was malignsncy(10 cases), namely, lung cancer, Hodgkin's lymphoma, other malignant lymphoma, leukemia and mediastinal mass, and the other diseases were tuberculosis of intenal organs, diabetes mellitus, hepatic diseases, cardiac diseases, chronic pulmonary diseases, cord injury, gastric ulcer, brain damage, burn, renal diseases, rheumatoid arthritis, and measles. 5. It was suggested that the distributuon of skin lesion were related to dermatome. The incidence of skin lesion was distributuon in the following region in order : T5-T8(25.4%), C6-T4(24.6%), Cl-C5(20.5%), Ll-S3(13.9%), Vl-V3 (12.3%), and T9-T12(3.3%), there was involvement of the entire thoracic dermatome(C6-T12) in 65 cases(53.3%). A great many cases of malignancy, chronic pulmonary disease, cardiac disease, tuberculosis and gastric ulcer were most frequently distributed in the thoracie dermatome, but the involvement of ophthalmic dermatome was found only in the patients with hypertension. 6. The most common complication was postherpetic neuralgia for 31 cases(25.4%) with the highest frequency in 60's(32.3%). Other complications were ophthalmic complication, Ramsay-Hunt syndrome, secondary bacterial infection, moter nerve involvement, difficulty of urination, and recurrent herpes zoster.