Admission HbA1c value as a prognostic marker in patients admitted with COVID-19

Background:Diabetes mellitus has been firmly established as a risk factor for the prognosis of COVID-19. However, the impact of pre-COVID-19 glycemic control on prognosis is yet to be fully understood. Our study aimedto establish the effect of HbA1c at admission on the outcome of patients admitted with COVID-19.Methods:It was a prospective observational study of admitted adult patients with confirmed SARS-CoV-2 infection in a tertiary care centre based on data collected from the medical record section using the patient data registry between April 2021 to June 2021. Information regarding demographic and clinical features, laboratory values, and hospital outcomes was collected and analysed.Results:182 patients admitted to the hospital with COVID-19 during the study period were included, their mean age was 48.75 years, the mean HbA1c was 6.1. Males accounted for 69.8% (127) of the sample population. 41.2% (75) were known diabetics. 44.8% (81) were known hypertensives. The mortality rate overall was 25.3% (46). 63.7% (116) had HbA1c values >6.5.High HbA1c values was associated with longer duration of hospital stay (p=0.032), higher levels of inflammatory markers, increased need for mechanical ventilation (p=0.001), higher mortality rate (p=0.001).Conclusions:Patients with COVID-19 with poor glycemiccontrol as evidenced by admission HbA1c levels were found to have more severe disease course with increased level of inflammatory markers, longer duration of hospital stay and higher risk of mortality

A Prospective Study on Anemia: Prevalence and Risk Factors in Children Under 5 Years of Age

Introduction: Anemia has several potential etiologies followedby acute blood loss and heredity or acquired diseases. Inyoung children, the most common cause of anemia is lowconsumption and absorption of iron-rich foods.Methodology: 100 children which was under the 5 year of ageincluded in this study. This study was conducted in Departmentof Pediatrics in Integral Institute of Medical Sciences &Research, Lucknow.Result: Result of this study revealed that in 31% casesmoderate anemia was seen, whereas in 24% cases mildanemia, 10% severe anemia was seen. While in 35% cases noanemia was seen.Conclusion: This study can be concluding that iron and othermicronutrient rich diet can provided to the children forprevention of anemia

Impressing for Excellence: Special Impression Techniques for Compromised Ridges: Case Report

Introduction: Prosthodontic rehabilitation of a patient withcompromised edentulous ridges in a conventional manneris a difficult task. Modifications in the treatment proceduresshould be considered to fulfil the patient's functional andesthetic desires.Case report: This case report describes various compromisedsituations like atrophic ridges, flabby ridges and knifeedge ridges encountered in a routine clinical practice andmodification of treatment plan for each of them.Conclusion: The treatment modifications for compromisedridges starts from accurate impression making which recordmaximum denture bearing area without interference withmovements. Recording the entire functional denture-bearingarea ensures maximum retention, stability and support for thedenture during use.

Microstomia: Difficult Proposition to Rehabilitate

Introduction: The rehabilitation of microstomia patientspresents difficulties during fabrication of denture as themaximal mouth opening is inadequate. This condition mayresult from the surgical treatment of orofacial cancer, cleft lip,trauma, burns, Plummer–Vinson syndrome or scleroderma.The reduced mouth opening also leads to difficulty in speech,mastication and psychological problems secondary to facialdisfigurement.Case report: It is often difficult to apply conventional clinicalprocedures to fabricate prosthesis for patients who demonstratelimited mouth opening, since it is difficult to follow theprotocol of fabrication of prosthesis and also insertion andremoval of one-piece prosthesis into the oral cavity. Thepresent case report focuses on rehabilitation of microstomiausing sectional prosthesis and intraoral magnets with whichenabled easier and competent removal and insertion by thepatient.Conclusion: The sectional denture attached by the magnetcan be more comfortably removed and inserted by the patientwith reduced mouth opening. It is simple and cost-effectivemethod for rehabilitation of microstomia patient.

Ebola Virus a Major Threat for Dental Professionals: A Review Article.

Ebola virus (EBOV) is the causative agent of lethal viral hemorrhagic fever. Since 1970, it has been found in sub-Saharan Africa. However, a current epidemic of 2014-2015, in West Africa, is caused by Zaire species of EBOV. This EBOV belongs to Filoviridae family. Term Filoviridae is derived from Latin word “Filum” meaning thread like based on its filamentous structure. Transmission of this virus can occur through various modes such as person to person, through animals and other routes. Person to person transmission occurs through direct contact with blood, body fluids, or skin of patients. Till date, there has been no reported case of transmission of the virus through saliva. However, some studies have confirmed the fact that all cases with detectable serum level of EBOV ribonucleic acid also show their level in saliva and also considering the fact that incubation period for all bodily fluids including saliva is 21 days. Thus, dental professionals are at risk of acquiring infection if infection control measures are not used. Hence, oral health care professionals should have a thorough knowledge about the oral manifestations of the disease to prevent life-threatening complications.

Oral Benign Fibrous Histiocytoma of Chin: A Rare Case Report and Literature Review.

Fibrous histiocytoma is a benign soft tissue neoplasm that may present as a fi brous mass any-where in the human body. Th e involvement of the oral cavity is extremely rare and very few cases have been reported in the literature until date. We here report a case of benign fi brous histiocytoma localized in the oral cavity in mandibular chin region and the treatment approach that need to be followed for such cases. Th e clinical and histological features of the lesion are discussed precisely in the light of a literature review of this pathology occurring in soft tissues in the head and neck region.

Eco friendly spectrophotometric method for quantitative estimation of lomefloxacin using hydrotropic approach.

The present work describes a novel, accurate, sensitive and economic safe spectrophotometric method was developed by application of hydrotropy, using 8 M Urea solution as hydrotropic solubilizing agent, for the quantitative determination of poorly watersoluble lomefloxacin HCl in tablet dosage form. There were more than 43 times enhancements in the solubility of lomefloxacin HCl increases in hydrotropic solution as compared to solubilities in distilled water. Lomefloxacin HCl shows maximum absorbance at 281 nm. Urea and other tablets excipents did not show any absorbance above 230 nm, and thus no interference in the estimation was seen. Lomefloxacin HCl was obeyed Beer,s law in the concentration range of 5 to 25μg/ml (r2= 0.9998) in hydrotropic solvent with mean recovery ranging from 98.03±0.65 to 98.59±0.32%. Proposed method is new, simple, economic, safe, rapid, accurate and reproducible. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. The method can be used for routine analysis in both research laboratories, and pharmaceutical and chemical industries to analyze the drugs without the use of organic solvents thus make the environment eco-friendly.