ABSTRACT
Objectives : To compare the efficacy of crystalloids and colloids as preloading infusion to prevent hypotension, requirement of vasopressors and requirement of total fluid given during surgery to maintain stable hemodynamic. Methodology : A total of 60 patients scheduled for elective lower abdominal, lower limb and gynaecological procedures were selected to participate in this prospective, randomized, double-blind study. Patients were randomly allocated into two groups for preloading. Group A received 15 ml/kg Ringer lactate for preloading and group B 5m1/kg gelatin for preloading. Vital parameters (PR, SBP, DBP, and MAP) were recorded. Incidence of hypotension in both groups was noted and requirement of mephentine to treat hypotension and total intravenous fluid required intraoperatively was also recorded. Results : After spinal anesthesia SBP in the crystalloid group decreases to minimum 101.77±14.18 after 15 minutes and rises again at the end of surgery. In colloid group systolic blood pressure decreases to minimum106.00±12.15 after 20 minutes and then increases at the end. P value 0.010, 0.015, 0.029, 0.046 during 8 20 min. suggest significant fall in SBP in crystalloid group. 40% pt. required mephentine to treat hypotension compared to 16.7% in colloid. Intraoperatively requirement of IV fluid in crystalloid group was 1662.33±179.30 and in colloid group was 1260.67±158.22. Conclusion : There was significant hypotension with crystalloid group intraoperatively in spite of preloading and also intraoperatively fluid requirement was high. The incidence of nausea, vomiting, rigors and postoperative hypotension was comparable in both groups.