ABSTRACT
Background and Aims: it is believed that uremia causes destruction of white blood cells [WBC] leading to leukopenia. This study attempted to assess the exact effect of uremia on WBC count
Materials and Methods: this case-control study was conducted on 120 uremic patients and 100 non-uremic control subjects. All cases were examined for determination of urea and creatinine in their serum; complete blood counts were also determined
Results and Conclusion: in healthy male individuals, the mean values of serum urea and creatinine were 14.5+/-1.9 and 0.9+/-0.2 mg/dL, respectively. In females the serum urea concentration was the same as males, but mean serum creatinine was 0.66+/-3.2 mg/dL. In the patients group, the mean concentration of serum urea for both sexes was 83+/-2.4 mg/dL. The mean values of creatinine in male and female patients were 2.4+/-1.3 mg/dL and 2.1+/-1.7 mg/dL, respectively. The mean total leukocyte counts in case and control groups were 6.08+/- 2.24 and 6.17+/- 2.43 ×10[9]/L, respectively [p=0.71]. Our results indicate that uremia cannot change leukocyte count