ABSTRACT
Metfomin, a biguanide antihyperglycemic drug, has been shown in improvement ovarian function and glucose metabolism in women with polycystic ovary syndrome [PCOS], but results concerning its effects on insulin sensitivity are controversial. Oral contraceptive pills are commonly used in the treatment of PCOS; but like metformin, their influence on insulin sensitivity is not well known. The aim of this study was to compare the clinical improvement between Metformin and Diane in women with polycystic ovary syndrome. This research was a prospective randomized clinical trial study. We randomized 60 [20-49 years old] women with PCOS either to metformin [500 mg] X3 daily for 6 months or to ethinyl estradiol [35 microg] cyproterone acetate [2 mg] oral contraceptive pills [Diane] for 6 months. This study prolonged for 2 years. Results showed that metformin significantly decreased the waist to hip ratio, body mass index [BMI], serum glucose and insulin concentrations and improved menstrual cyclicily hirsutism score and Insulin sensitivity. Diane decreased hirsutism score and improvement in .the menstrual pattern but slight effect in carbohydrate metabolism and increase serum glucose. Metfomin, probably by way of its effects on adipose tissue, leads to reduction of hyperinsulinemia and concomitant improvement; in the menstrual pattern and clinical manifestation hyperandrogenism and therefore, it offers a useful alternative treatment for anovulatory women with PCOS. Dian slight increased in fasting glucose, BMI and Waist To hip ratio but it is an effective treatment for women with hyperandrogenism and hirsutism