ABSTRACT
The number of cases of cardiovascular disease, the leading causes of death at any age group in the world, is rising rapidly now-a-days. Disorder in lipid metabolism is one of the main determinants of cardiovascular risk. The primary target of lipid management is to achieve low-density lipoprotein cholesterol at goal. Methods: The study included total 70 cases, among which 40 were males and 30, were females. Sample size calculation was done according to the standard methods available. Results: On statistically analyzing the data, it is clearly indicated that atorvastatin has a significant effect on the lowering of hs-CRP levels (p=0.01), reducing LDL-C levels (p=0.006), elevating HDL-C levels (p=0.03) along with reducing TC (p=0.002) and TG (p=0.004) levels in obese T2DM patients. Conclusion: Treatment with Atorvastatin leads to a significant reduction in plasma Total cholesterol, LDL cholesterol and Triglyceride levels, lowering of plasma CRP and an improvement in endothelial dysfunction.