Decreased ability of human plasma to inhibit lipid peroxidation in uremia

Blood samples from normal healthy volunteers and uremic patients were obtained and plasma were prepared. The effects of these plasma samples on lipid peroxidation [LP] in rabbit homogenate were determined. Both plasma samples inhibited LP activity in our experiments. The percent inhibition of LP produced by normal plasma, concentration 1 and 10%, v/v, was 21.78 +/- 4.15 and 75.5 +/- 2.39 [Mean +/- S.E.M. n=20] respectively. The corresponding values of LP inhibition obtained using the uremic plasmas, concentrations 1 and 10% v/v, were 6.85 +/- 7.04 and 57.12 +/- 13.71 respectively. These data show that there was a significant reduction in LP inhibitory activity in plasma of uremic patients. This suggests that there may be an increased production of associative LP products in uremic patients. Since LP products profoundly affect blood clotting it can be inferred that aberrant levels of LP inhibitor in uremic plasma could contribute to increased bleeding in uremia

Congenital obstruction of the ureterovesical junction

An unusual case of unilateral congenital ureterovesical junction obstruction leading to recurrent urinary tract infection and renal parenchymal damage is reported. Following radiological diagnosis, the five years old patients underwent a distal right ureterectomy and a ureteronecystostomy. The patient is asymptomatic and off all medications 8 months following surgery

Biopsy for suspected testicular cancer

The current practice of radical orchidectomy for any lesion in the testis, suspected of being malignant is not keeping with an important principle of surgery, viz., that one should always biopsy before radical surgery. This paper discusses the risk of blind orchidectomy, and of testicular biopsy done after clamping the chord. Methods of preventing warm ischaemia are discussed and the possibilities of obtaining a firm diagnosis without biopsy are explored. An attempt has been made to identify the groups of individuals at risk for testicular cancer. These should be kept under surveillance and the testis subjected to biopsy at the slightest suspicion of a mass