ABSTRACT
Background: The occurrence of Atrial Fibrillation [AF] is linked to an increased inflammatory response after cardiac surgery that is significantly decreased by anti-inflammatory treatments. The present study aimed at administrating Colchicine as a way to reduce the incidence of post- Coronary Artery Bypass Graft [CABG] atrial fibrillation. Methods: In this double-blind, parallel clinical trial, 216 patients with coronary artery disease who underwent CABG surgery, by using a table of random numbers are divided into intervention and control groups to receive placebo or Colchicine
The clinical and surgical characteristics of the patients in two groups were similar
The intervention group received 1.0 mg of Colchicine tab, the night before surgery and on the morning of surgery. This drug followed by 0.5 mg twice a day for five days after surgery. On the other hand patients in the control group received only placebo [ineffective pill with similar size to Colchicine]
After operation two groups were compared regarding important outcomes such as postoperative arrhythmia, ICU stay and hospital stay
The data were assessed using SPSS software [version 17] and t-test and x2 statistical tests. Results: One hundred fifty six men and sixty women with a mean age of 59.9 +/- 9.3 years were enrolled in the study in two Colchicine and placebo groups [each consisting of 108 patients]
The incidence of postoperative atrial fibrillation was 14.8% in the Colchicine group and 30.6% in the control group [P= 0.006]
ICU stay in the Colchicine group were 2.4+/-1.3 days versus 3.1+/-1.5 days in controls [P< 0.001] and hospital stay in the Colchicine group were 6.6+/-1.5 days versus 8.1+/-2.0 days in controls [P< 0.001]
Conclusion: Colchicine is an anti-inflammatory medication and has very few side effects at low doses
According to the 48% reduction in the incidence of atrial fibrillation in Colchicine patients undergoing coronary artery bypass grafting surgery, this drug can be prescribed as a prophylaxis for prevention of post-CABG atrial fibrillation
ABSTRACT
Heart transplantation in Iran was first performed in July 1993. Since then, Shariati Hospital, affiliated to Tehran University of Medical Sciences, has been representing the most active center of cardiac transplantation in Iran and one of the major sites in the Middle East. This is a comprehensive review of our 15-year practice registry to make a scheme of our record and achievements. Clinical data on all consecutive transplanted patients from the Department of Cardiac Surgery, Shariati Hospital, Tehran, Iran over the last 15 years were reviewed. Descriptive and analytical statistics were extracted in regard to recipients, donors, surgical characteristics, and current status of the patients on follow-up. Totally, 90 patients were transplanted since 1993; 11, 32, and 47 in three five-year periods, respectively. The mean age of the recipients was 29.30 +/- 13.17 years. Motor-vehicle accident was the main cause of brain death of donors [48.8%]. The most common indication for surgery was idiopathic dilated cardiomyopathy [75.5%].The mean survival rate has been 6.66 +/- 0.87 years. One-year and five-year survivals had a rising trend through the five-year periods. Acute allograft rejection and infection were the two major events complicating our transplants. This study shows that despite a vast variety of obstacles, we have passed the primitive milestones. The number of transplants is increasing at a higher rate in recent years, and patients' survival rates and outcomes seem to be improving
Subject(s)
Humans , Male , Female , Retrospective Studies , Tissue Donors , Accidents, Traffic , Brain Death , Cardiomyopathy, Dilated , Survival Rate , Transplantation, Homologous , Graft Rejection , Treatment Outcome , Tissue and Organ HarvestingABSTRACT
The aim of the present study was to determine the effect of different restorative materials on fracture resistance of mandibular teeth with class V restorations. One hundred intact mandibular incisors were selected and divided into ten groups with 10 samples in each. Three types of restorative materials; Tetric flow composite [Vivadent Ets, Schaan/Liechtenstein], Compoglass [Vivadent Ets,Schaan/Liechtenstein] and light curing glass ionomer [GC Corporation Tokyo JAPAN] were used in our study. Each of these materials were applied in cavities with 2, 3 and 4 mm widths. Group 10 was considered as the control group in which no restorations was done. All teeth were mounted in cold cure acrylic resin [Tray Resin II, Shofu Inc, Kyoto, Japan] and the samples were tested by applying shear force with cross head speed of 5mm/min in a universal testing machine [Instron corp., Canton, MA,USA]. Data were analyzed with two way ANOVA and Dunnet multiple comparisons test using SPSS 10 software package. Regardless of the types of materials, cavities with 4mm width had less bond strength than those with 2 and 3 mm widths [P-value=0.555]. In the Compoglass and glass ionomer L.C. groups, cavities with 2 and 3mm widths had significant greater strength than cavities with 4mm width [P-value=0.0002]. In groups with Tetric flow restorative material no significant difference in shear force among different widths of cavities were detected [P-value=0.4948]. The mean shear force in this group was comparable with the control group [P-value=0.0001]. In cavities 2 and 3 mm widths, there was not any significant difference in shear force between Tetric flow and compoglass restorative materials. Glass ionomer and Tetric flow had the least and the highest shear bond strength ,respectively. The results showed that although all the restorations need an average load more than masticatory forces in the mouth to fail, but Tetric flow composite with combination of chemical adhesion properties and optimum elastic characteristics was proven to be the restorative material of choice for cervical Defects with different widths