Dexmedetomidine and ketamine sedation for a patient with presumed mitochondrial disease and malignant hyperthermia

Mitochondrial disorders and malignant hyperthermia are two co-morbid conditions which present their own anesthetic difficulties. However, the combination of both pathologies in one patient presents a particularly unique problem with regards to anesthetic management and perioperative care. We present the case of a 20-year-old with both a mitochondrial disorder and malignant hyperthermia history. The perioperative implications of these disorders are discussed and options for anesthetic care reviewed