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Abstract Introduction Selective neck dissection inclinically node-negative neckisconsidered the standard of care for oral squamous cell carcinomas (SCCs). Controversy still prevailsinnode-positive disease regarding the extent of neck dissection. In our part of the world, comprehensive neck dissection is mostly considered to be the minimal optimal treatment for palpable neck disease. Objective To compare regional control and disease-specific survival between clinically node-positive and node-negative patients undergoing selective neck dissection for oral SCC. Methods This was a retrospective cohort study conducted in the department of ENT, Head and Neck surgery at a tertiary care hospital. All patients with biopsy-proven oral and lip SCC, with or without nodal disease, who underwent selective neck dissection between April 2006 and July 2015 were included in the study. Results During the study period, 111 patients with oral SCC underwent selective neck dissection, of whom 71 (62%) were clinically node-negative and 40 (38%) patients had clinically positive nodes in the neck. The mean follow-up was 16.62 months (standard deviation [SD]: 17.03). The overall regional control rates were 95 versus 96% for clinical negative versus positive nodes, respectively (p = 0.589). The disease-specific survival was 84.5% in the node negative group versus 82.5% in the node-positive group (p = 0.703). Conclusion Selective neck dissection in node-positive neck oral SCC has similar regional control rates when compared with node-negative neck SCC. The difference in disease-specific survival between the two groups is also not significant.
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Abstract Introduction: Tracheostomy is commonly performed surgical procedure in ENT practice. Postoperative care is the most important aspect for achieving good patient outcomes. Unavailability of standard guidelines on tracheostomy management and inadequate training can make this basic practice complex. The nursing staff and doctors play a very important role in bedside management, both in the ward and in the intensive care unit (ICU) setup. Therefore, it is crucial that all healthcare providers directly involved in providing postoperative care to such patients can do this efficiently. Objectives: The objective of this study is to assess the knowledge regarding identification and management of tracheostomy-related emergencies and early complications among healthcare professionals so as to improve practice and further standardization. Methods: Cross-sectional observational study included two hundred and fifty-four doctors and nurses from four large tertiary care hospitals. The questions used were simple and straightforward regarding tracheostomy suctioning, cuff care, cuff management, tube blockage, and feeding management in patients with tracheostomy. Results: Based on evidence from our study, knowledge level regarding tracheostomy care ranges from 48% to 52% with knowledge scores above 50% being considered satisfactory. Significant gaps in knowledge exist in various aspects of tracheostomy care and management among healthcare professionals. Conclusion: Our findings demonstrated an adequate knowledge level among health care professionals ranging from 48% to 52% with knowledge scores above 50% being considered satisfactory and revealed that gaps in knowledge still exist in various aspects of tracheostomy care and management.
HIGHLIGHTS Healthcare workers should be well versed in identifying tracheostomy management, its complications and responding accordingly. Doctors and nurses (131 =52%) possessed good knowledge about various aspects of tracheostomy care and management. The poorest scores were regarding cuff pressure (38.9%), suction pressure (39.4%) and first response in tube blockade (31.1%). Higher scores were found in age group 26 to 30 years (54.2%) and those having 1-3 years of clinical experience (41.2%). No statistically significant assoiation of knowledge regarding tracheostomy care was apparent with age, gender or years of practice.
Resumo Introdução: A traqueostomia é um procedimento cirúrgico comumente feito na prática otorrinolaringológica. O cuidado pós-operatório é o aspecto mais importante para alcançar bons resultados para o paciente. A indisponibilidade de diretrizes padrão para o manejo da traqueostomia e o treinamento inadequado podem tornar complexa essa prática básica. A equipe de enfermagem e os médicos desempenham um papel muito importante no manejo à beira do leito, tanto na enfermaria quanto na unidade de terapia intensiva (UTI). Portanto, é crucial que todos os profissionais de saúde diretamente envolvidos na prestação de cuidados pós-operatórios a esses pacientes possam fazer isso de forma eficiente. Objetivo: Avaliar o conhecimento sobre a identificação e manejo de emergências relacionadas à traqueostomia e complicações precoces entre os profissionais de saúde, a fim de melhorar a prática e sua padronização. Método: Estudo observacional transversal que incluiu 254 médicos e enfermeiras de quatro grandes hospitais terciários. As perguntas foram simples e diretas em relação à aspiração da traqueostomia, cuidados com o cuff, manejo do cuff, obstrução da cânula e manejo da alimentação em pacientes traqueostomizados. Resultado: Com base nas evidências de nosso estudo, o nível de conhecimento sobre os cuidados com a traqueostomia varia de 48% a 52%, com escores de conhecimento acima de 50% considerados satisfatórios. Existem lacunas significativas no conhecimento em vários aspectos dos cuidados e manejo da traqueostomia entre os profissionais de saúde. Conclusão: Nossos achados demonstraram um nível de conhecimento adequado entre os profissionais de saúde, variação de 48% a 52%, com escores de conhecimento acima de 50% considerados satisfatórios e revelaram que ainda existem lacunas no conhecimento em vários aspectos do tratamento e manejo do paciente traqueostomizado.
DESTAQUES Profissionais de saúde devem estar bem familiarizados com a identificac¸ão do manejo da traqueostomia, suas complicac¸ões e como agir de acordo com a necessidade. Médicos e enfermeiras (131 = 52%) possuíam bons conhecimentos sobre vários aspectos dos cuidados e manejo da traqueostomia. Os piores escores foram em relac¸ão à pressão adequada do cuff (38,9%), à pressão de aspirac¸ão adequada (39,4%) e primeiros socorros em caso de obstruc¸ão da cânula (31,1%). Os melhores escores foram encontrados no grupo 26 a 30 anos (54,2%) e aqueles com experiência clínica de 1-3 anos (41,2%). Não houve associac¸ão estatisticamente significante entre o conhecimento sobre os cuidados com a traqueostomia, idade e gênero e os anos de prática de médicos e enfermeiras.
Subject(s)
Tracheostomy/adverse effects , Intensive Care Units , Cross-Sectional Studies , Health Personnel , Delivery of Health CareABSTRACT
Aims: This study aims to assess differences in severity of short-term (<1 year) and long-term (_x005F_x0001_1 year) adverse CV outcomes after PCI in insulin-treated vs. non-insulin-treated diabetes mellitus (DM) patients. Methods: A systematic search on Pubmed and Embase led to the incorporation of 29 studies that compared post-percutaneous coronary interventional outcomes in insulin-treated and non-insulintreated diabetes mellitus. Diabetes mellitus (type 2) was defined as fasting blood glucose (FBG) level of >7.0 mmol/L or with an oral glucose tolerance test (OGTT) level of >11.1 mmol/L at least on two separate occasions. Adverse CV outcomes were assessed in insulin-treated and non-insulin-treated DM after the PCI procedure considered for the analyses were mortality, MACE, TLR, TVR, MI, stent thrombosis, target lesion failure (TLF), and need for-post PCI CABG. Data were pooled and analyzed using Review Manager 5.3, and risk ratios (RR) with respective 95% confidence intervals (CI) were calculated.The statistical analyses were carried out by Review Manager v.5.3, and the data were pooled using a random-effects model. Risk ratios (RRs) with 95% confidence intervals (CI) were reported along with forest plots. The chi-square test was performed to assess for differences between the subgroups. Heterogeneity across studies was evaluated using Higgins I2 statistics. Visual inspection of the funnel plot and Begg's regression test were used to assess publication bias. Results: A total of 40,527 patients (11742 in the Insulin-treated diabetes mellitus group and 28785 in the non-insulin-treated DM group) who underwent PCI were included. The pooled analysis of short-term follow up outcomes preceding PCI demonstrated a significantly higher risk of mortality (RR ¼ 1.75 [1.24,2.47]; p ¼ 0.002), MI (RR ¼ 1.81[1.14,2.87]; p ¼ 0.01], stent thrombosis (RR ¼ 1.63[1.13, 2.35]; p ¼ 0.009) and target lesion revascularization (TLR) (RR ¼ 1.29[1.02,1.63]; p ¼ 0.03) in insulin-treated DM patients. Similarly, analysis of long-term follow-up studies depicted a significantly higher risk mortality (RR ¼ 1.55 [1.22, 1.97]; p ¼ 0.0003), MI (RR ¼ 1.63 [1.35, 1.97]; p¼<0.00001), MACE (R ¼ 1.47 [1.31, 1.65]; p¼<0.00001), stent thrombosis (RR ¼ 1.54 [1.19,1.99]; p ¼ 0.001), TLR (RR ¼ 1.40 [1.18, 1.66]; p ¼ 0.0001), target vessel revascularization (TVR) (RR ¼ 1.35 [1.11, 1.64]; p ¼ 0.003) in insulin-treated DM group after PCI versus non-insulin-treated DM patients. Conclusion: Despite a tremendous technical success rate of multi-vessel stenting, people living with diabetes who were being treated with insulin had higher long-term, and short-term mortality rates, MI, TLR, TVR, and stroke compared to people living with diabetes who were being treated with means other than insulin and are more prone to detrimental cardiovascular outcomes.
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Background@#Plagiarism is one of the most common violation of publication ethics, and it still remains an area with several misconceptions and uncertainties. @*Methods@#This online cross-sectional survey was conducted to analyze plagiarism perceptions among researchers and journal editors, particularly from non-Anglophone countries. @*Results@#Among 211 respondents (mean age 40 years; M:F, 0.85:1), 26 were scholarly journal editors and 70 were reviewers with a large representation from India (50, 24%), Turkey (28, 13%), Kazakhstan (25, 12%) and Ukraine (24, 11%). Rigid and outdated pre- and post-graduate education was considered as the origin of plagiarism by 63% of respondents. Paraphragiarism was the most commonly encountered type of plagiarism (145, 69%). Students (150, 71%), nonAnglophone researchers with poor English writing skills (117, 55%), and agents of commercial editing agencies (126, 60%) were thought to be prone to plagiarize. There was a significant disagreement on the legitimacy of text copying in scholarly articles, permitted plagiarism limit, and plagiarized text in methods section. More than half (165, 78%) recommended specifically designed courses for plagiarism detection and prevention, and 94.7% (200) thought that social media platforms may be deployed to educate and notify about plagiarism. @*Conclusion@#Great variation exists in the understanding of plagiarism, potentially contributing to unethical publications and even retractions. Bridging the knowledge gap by arranging topical education and widely employing advanced anti-plagiarism software address this unmet need.
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Background@#Plagiarism is one of the most common violation of publication ethics, and it still remains an area with several misconceptions and uncertainties. @*Methods@#This online cross-sectional survey was conducted to analyze plagiarism perceptions among researchers and journal editors, particularly from non-Anglophone countries. @*Results@#Among 211 respondents (mean age 40 years; M:F, 0.85:1), 26 were scholarly journal editors and 70 were reviewers with a large representation from India (50, 24%), Turkey (28, 13%), Kazakhstan (25, 12%) and Ukraine (24, 11%). Rigid and outdated pre- and post-graduate education was considered as the origin of plagiarism by 63% of respondents. Paraphragiarism was the most commonly encountered type of plagiarism (145, 69%). Students (150, 71%), nonAnglophone researchers with poor English writing skills (117, 55%), and agents of commercial editing agencies (126, 60%) were thought to be prone to plagiarize. There was a significant disagreement on the legitimacy of text copying in scholarly articles, permitted plagiarism limit, and plagiarized text in methods section. More than half (165, 78%) recommended specifically designed courses for plagiarism detection and prevention, and 94.7% (200) thought that social media platforms may be deployed to educate and notify about plagiarism. @*Conclusion@#Great variation exists in the understanding of plagiarism, potentially contributing to unethical publications and even retractions. Bridging the knowledge gap by arranging topical education and widely employing advanced anti-plagiarism software address this unmet need.
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Background: The aim of the study was to determine the degree of awareness and practice of proper menstrual hygiene management among women living in low-income neighbourhood in Karachi, Pakistan.Methods: A cross-sectional study was conducted at the Bizerta Lines, Karachi between January and June 2019. All women of reproductive age were included in the study. Amenorrheic, menopausal, or women on birth control were excluded from the study. Degree of awareness and current practices pertaining to menstrual hygiene management were assessed through pro-forma. The study tool collected the participant’s knowledge, awareness, and misconceptions about menstruation. The factors affecting the quality of life during menstruation of women living in poor socio-economic conditions were also observed. Statistical Package for Social Sciences (SPSS v.23) was used to analyze the collected data.Results: Of the 338 participants, 82.5% had no knowledge of menstruation prior to their first menstrual period. Only a minority of the women knew that the source of menstrual blood was the uterus while 41.4% of the women incorrectly claimed that the menstrual blood and urine were expelled from the same orifice. More than half of the participants used disposable sanitary napkins (55.5%). 65% of the participants changed the absorbent at least 1 to 3 times a day.Conclusions: Most of the participants used disposable sanitary napkins. However, the basic knowledge of female anatomy and physiology behind menstruation was poor among women.
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In the suburbs of big cities, the vegetables are commonly irrigated with effluents due to paucity of good qualitywater. These effluents are loaded with toxic or heavy metals which may cause environmental or health hazard.The present study was performed in pot experiments to investigate the impacts of different effluents on thegrowth, yield, and heavy metals concentration of turnip (Brassica rapa). Pots were arranged in a completelyrandomized design with six treatments replicated four times. The treatments included 10% effluents ofsugar mill, sewage water, soap factory, ghee mill, slaughterhouse, and control. Data on the weight of rootplant−1 (g), root length, root diameter, yield ha−1, and heavy metals (Fe, Pb, Zn, Ni, and Cd) concentrationsin roots were recorded and analyzed statistically. Results revealed that higher yield and related traits wererecorded with sewage water followed by slaughterhouse wastage and sugar mill effluent. Application of sewagewater enhanced 11.2% yield while the increment with slaughterhouse wastage and sugar mill effluent was 7.8%and 2.3%, respectively. Heavy metal concentrations were increased with all types of effluents. The transferfactors showed that accumulation of metals was in the order of Pb > Cd > Zn > Fe > Ni.
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Skeletal muscle involvement in Hodgkin lymphoma is very rare. An 11-year male child presented with stage IV Hodgkin lymphoma and skeletal muscle involvement in right gluteal, piriformis and psoas muscles. He had resistant disease. He achieved remission with 3rd line chemotherapy, EPIC; and successfully underwent high dose chemotherapy with autologous stem cell rescue. The patient is well after 15 months of follow-up. Successful treatment signifies positron emission computed tomography [PET/CT] evaluation and multidisciplinary team discussions in diagnosis and management of a rare Hodgkin lymphoma presentation
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Van der Knaap disease or megalencephalic leukoencephalopathy with subcortical cysts [MLC] is a rare, inherited, autosomal recessive disorder. It is characterised by macrocephaly and slowly progressive ataxia, spasticity, and cognitive decline. The usual age of onset is described from birth to infancy. MLC predominantly occurs in some ethnicities where consanguinity is common. This disease is caused by mutations in the gene, which encodes a novel protein, MLC1. The characteristic MRI findings include leukodystrophy and subcortical cysts that yield diagnostic clue in most of the cases. The diagnosis can be established prenatally and genetic counseling is usually offered for future pregnancies. Herein, we chronicle a case of Van der Knaap disease from Pakistan with the classical MRI features
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Objective: To see the frequency of incidental fatty liver on ultrasound and its association with diabetes mellitus and hypertension
Methods: A cross sectional study was conducted from January 2016 to June 2016 in the department of Surgery and Radiology at Hamdard University Hospital. Patients of both genders and all ages were selected by non purposive convenience sampling. Critically ill, trauma cases and all those patients who had a history of chronic liver disease, alcohol intake and expected pregnancy were excluded. Blood pressure and random blood sugar were recorded
Results: Six hundred patients were included in the study with mean age of 44.65+/-18.8 years. 240 patients [40 percent] had incidental finding of fatty liver on ultrasound. Out of 240 with fatty liver patients 117 were males [48.8 percent] and 123 were females [51.3 percent]. Total 141 patients were diagnosed with hypertension, out of which 81[57.44 percent, p< 0.001] had fatty liver on ultrasound. Diabetes mellitus was diagnosed in 84 patients, in which 57 patients [67.8 percent, p<0.001] had fatty liver
Conclusion: Fatty liver is a frequently found incidental finding on ultrasound. There is a significant association of fatty liver with diabetes mellitus and hypertension
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Objective: To evaluate the analytical and diagnostic challenges in interpreting the various organic acid results by gas-chromatography-mass spectrometry and to devise a protocol for analysis that is beneficial for prompt interpretation and diagnosis
Study Design: Retrospective study
Place and Duration of Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from Apr 2015 to May 2017
Material and Methods: We reviewed clinical data, biochemical investigations and urine organic acid profiles of 110 patients received for evaluation of a suspected organic acid disorder. Urine organic acid analysis was carried out by gas chromatography - mass spectrometry using Mass Hunter software
Results: A total of 104 [99 percent] cases received were from the pediatric patients and 7 [6.3 percent] from adult patients. A total of 11 different organic acidurias were diagnosed. Other diseases [n=10] were also detected on the basis of their pathognomics metabolites and included tyrosinemia type 1 [n=4], alkaptonuria [n=5] and ornithine transcarbamoylase deficiency [n=1]. Twenty eight [25 percent] urine samples were either recalled or repeated for reasons like random urine sample yielding negative profiles in setting of a strong suspicion for organic aciduria [n=6], non-availability of clinical data [n=12] or delay in transportation >8 hours [n=10]. Raised non-specific organic acid metabolites were seen in 23 [21 percent] cases. Lactic acid and ketones were detectable in 12 [11 percent] samples in the absence of raised plasma levels
Conclusion: Urine OA profiles must be interpreted in context of complete clinical, nutritional and biochemical findings. Each laboratory equipped with this facility should devise their analytical protocols for meaningful interpretation of results
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Mucormycosis is a life threatening fungal infection and remains an important cause of morbidity and mortality in immunocompromised patients after hematopoietic stem cell transplant. We report here a case of hepatosplenic mucormycosis in a patient after autologous stem cell transplant. A young man with anaplastic large cell lymphoma underwent autologous hematopoietic stem cell transplant after achieving complete remission with standard chemotherapy and consolidative radiotherapy. He was found to have incidental hepatosplenic hypodensities on follow up imaging, that were proved to be mucormycosis on histopathology after getting CT-guided biopsy of splenic lesions. He was treated with intravenous amphotericin-B followed by complete radiological resolution of hepatosplenic lesions. Although these infections are often life threatening but limited disease may have better outcome if diagnosed and treated early and aggressively
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Objective To compare the clinical efficacy of trichloroacetic acid [TCA] 100% and cryotherapy in xanthelasma palpebrarum [XP]
Methods 40 patients fulfilling the inclusion criteria were treated with cryotherapy on right eye [group A] and TCA on left eye [group B]. Patients were followed up for 6 weeks and final outcome variable of efficacy i.e. complete resolution of xanthelasma was assessed at 6 weeks. Adverse side effects of therapy were also recorded as secondary outcome variables. Data were analyzed by SPSS 19.0
Results Mean age of patients was 43.75 +/- 5.90 years and age ranged from 34 to 56 years. Out of 40 patients 9 [22.5%] were male and 40 [77.5%] were female. Complete resolution of xanthelasma was seen in only 7 [17.5%] in group A, while complete resolution of lesions was seen in 30 [75%] of patients in group B [p = 0.000]
Conclusion A single session of 100% TCA is highly effective than cryotherapy in the treatment of Xanthelasma palpebrarum
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Objective: To study the effectiveness of mandala-coloring as a therapeutic intervention for reducing anxiety in university students
Study Design: Quasi experimental study
Place and Duration of Study: International Islamic University Islamabad, from Feb to Jun 2016
Material and Methods: A sample of 100 university students of 13-18 years of education was taken [men=50, women=50] with the age range of 18 to 34 years. Convenience sampling technique was used. A pretest-posttest design was adopted in which State-Trait Anxiety Inventory was administered to measure the levels of State Anxiety and Trait Anxiety before and after coloring a pre-drawn mandala
Results: Results were analyzed using t-test. They indicated that there was a significant difference in the levels of State and Trait Anxieties in the pretest and posttest measures in both men and women
Conclusion: Using mandala-coloring as a therapeutic intervention can reduce State Anxiety and Trait Anxiety in university students
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Background the gestational diabetes mellitus [GDM] is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Risk management of GDM should be done at first prenatal visit. As it is the most common metabolic complication of pregnancy, the present study was focused on finding out the risk factors of GDM in local population
Method we evaluated the risk factors of GDM in 200 females who were randomly tested for GDM with 75 g Oral glucose tolerance test [OGTT] at 24-28[th] weeks of pregnancy. A detailed questionnaire was administered in this cross sectional study
Results the most commonly observed risk factor was family history DM,117 patients [p<0.001and odd ratio as 40.4 [17.4 to 93.6]], obesity,113 patients [P< 0.001, odd ratio as 4.5[2.2 to 9.2]], pregnancy related stress in109 [P< 0.001, odd ratio as 4.8[2.4 to 9.5]], anemia in 88 females [P=0.003, odd ratio as 3.5[1.5 to 8.0]], history of abortions,76 [P< 0.001], odd ratio as 2.9[1.59 to 5.34]]. Furthermore, stress, hypertension, lack of exercise were significantly associated risk factors of GDM. Only 93 females who had fatigue during pregnancy [P=0.718 and odd ratio as 0.88[0.45 to 1.71]] had association with development of GDM that was statistically insignificant
Conclusion the most commonly occurring risk factor of GDM in our population were obesity, family history of diabetes, stress, hypertension and lack of exercise. Unusual association was observed between iron deficiency anemia and GDM
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Objective: to understand various predisposing factors for tuberculosis infection that help to prioritize tuberculosis research and intervention among the most vulnerable persons in our population
Methods: it was cross sectional study which was conducted in Lahore .The duration was from December 2013 to May 2015. A total of 129 cases of tuberculosis were included in the study
Results: questionnaire was completed for 129 tuberculosis subjects. 65 patients [51.39%] were male and 64 [49.61%] female, among the total number of subjects, Diabetes was the most common illness among chronic diseases. Smoking was the most common addiction and all smokers were male
Conclusion: there are multiple environmental and host related factors, present in tuberculosis patients in Lahore. A proper understanding of their risk factors will contribute in appropriate disease management
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To determine the correlation between peer and instructor assessment. Correlation study. College of Physicians and Surgeons Pakistan [CPSP], in. department of Medical Education [DME] from November 2011 to March 2012. All participants enrolled in MCPS-Health Professions Education program of 2011-2013 [n=21 in 1[st] session and n=21 in 2[nd] session] consented for inclusion in the study. During contact sessions the participants gave lecture presentations of 10 minutes duration, on topics of their choice but preferably related to medical education. The lecture was appraised by both the instructors and the fellow participants using evaluation forms with 5 point Likert scale. Each aspect of the presentation was assessed and scored. The Pearson's coefficient of correlation, between scores awarded by participants and scores awarded by instructors was found to be 0.63 [p= 0.002] in the l[st] contact session. By 2[nd] contact session the correlation improved from moderate to high turning out to be 0.80 [p < 0.00l]. The study provides a sound evidence that; Peer assessment is comparable to faculty assessment and hence can be used more frequently to steer students' learning towards learning outcomes
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Humans , Male , Female , Educational Measurement , Statistics as Topic , Education, Medical , Students, MedicalABSTRACT
To determine the management outcome of the endoscopic band ligation in the patients with internal haemorrhoids at isra university Hospital Hyderabad Sindh. Pakistan. All the patients were under went sigmoidoscopy and colonoscopy for the complete diagnosis and the patients were excluded, if polyps or evidence of malignancy was found at colonoscopy. Haemorrhoids were sucked with the tip of endoscope from the anal canal and elastic bands were applied. After first treatment session, patients were asked to complete a questionnaire to evaluate the subjective satisfaction, which was classified as poor, good and best. Patients who had with multiple haemorrhoids were recalled for the ligation on remaining haemorrhoids after 2 weeks, if indicated. Total 100 patients were included in the study. In complications, intensive pain was found in the 55% of the cases while other complications were seen in very few patients and many patients were seen without any complication. Hospital stay was only one day was noted in the very few patients and mostly patients were discharged after few hours of the procedure. Outcome of the endoscopic band ligation was found excellent in 40% of the cases, good results found in the 45% of the cases and poor results were seen only in the 15% of the cases. Re-endoscopic band ligation was done in the 20% of the cases and recurrence of hemorrhoids was noted in the 30% of the cases. We concluded that the endoscopic band ligation is very good management for haemorrhoids without typical complications, with very short hospital stay and recurrences rate
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Asthma is a chronic inflammatory disorder of the airways, which is associated with excessive airway narrowing in response to stimuli that have little or no effect on healthy subjects. Airway hyper-responsiveness with a short duration of asthma is coupled with airway inflammation which may or may not be associated with lung impairment
Objectives: To study correlation of asthma duration with total anti oxidant capacity and lung function parameters
Design: Cross sectional study
Period: June 2013 to Dec 2013
Setting: Baqai Medical University and Hospital
Methodology: A total of 92 known and diagnosed cases of asthma meeting the inclusion criteria were recruited in the study. The subjects included both male and female with age ranging from 16-70 years. Portable handheld electronic Spirometer was used for performing spirometry. FRAP assay was done to measure TAC according to the method of Benzie and Strai
Results: The mean age of patients [n-92] was 34.88 +/- 12.14 SD. The mean duration of asthma was 11.57 +/- 11.30 SD years. Mean value of TAC was found to be 11.46 +/- 4.34SD. Mean FEVI was 1.90 +/- 0.82SD, mean FVC was 2.17 +/- 0.88 SD, mean PEFR was 247.8 +/- 122.7 SD and mean FEV[1]/FVC was 86.21 +/- 16.58 SD. Paired sample t - test was applied to compare the spirometric values which were found highly significant. Pearson correlation was applied and showed negative but insignificant correlation of asthma duration with patients' FEV[1], FEV[1]/FVC and PEFR as well as insignificant correlation with other spirometric parameters and TAC
Conclusion: Our study showed that duration of asthma has no significant correlation with lung function parameters and antioxidant capacity