ABSTRACT
The clinical characteristics arld prognosis of stroke were observed on 37 patients (25 men and 12 women) with chronic renal failure (CRF), who were admitted to Keimyung University Dongsan Hospital from Jan. 1984 to Aug. 1991. The results were as follows: 1. Their mean age was 50 years and the peak incidence was in the 5th and 6th decades. Male to female ratio was 2.1:1. 2. The stroke was complicated in 23 patients(2.0%) arnong 1179 hemodialized ones, and the mean duration of hemodialysis before attack of stroke was 15.7 months (1 week 46 months). 3. The causative renal diseases of CRF patients were as follows: 29 chronic glomerulonephritis, 6 hypertensive and 2 diabetic nephrosclerosis. 4. The major risk factors of stroke were hypertension, smoking, old age, hypercholesterolemia and it was suggested that heparin administration was also important factor in hemodialysis group. 5. The types of stroke were as follows: 11 intracerebral hemorrhage, 3 subdural hematoma, 2 subarachnoid hemorrhage and 4 cerebral infarction in hemodialysis group, and 6 cerebral infarction. 4 intracerebral hemorrhage, 2 subarachnoid hemorrhage and 1 transient ischemic attack in conservative treatment group. 6. The stroke was the most common cause of death in hemodialysis group. 7. The mortality rate of stroke was 82.6% in hemodialysis group and 7.1% in conservative treatment group.
Subject(s)
Female , Humans , Male , Cause of Death , Cerebral Hemorrhage , Cerebral Infarction , Glomerulonephritis , Hematoma, Subdural , Heparin , Hypercholesterolemia , Hypertension , Incidence , Ischemic Attack, Transient , Kidney Failure, Chronic , Mortality , Nephrosclerosis , Prognosis , Renal Dialysis , Risk Factors , Smoke , Smoking , Stroke , Subarachnoid HemorrhageABSTRACT
This study was performed to evaluate the titer of serum acetylcholine receptor antibody (AChR-Ab), the correlation between AChR-Ab titer and clinical state, clinical response to thymectomy and histopathologic finding of thymus in myasthenia gravis. Twenty-seven patients with various clinical grades of myasthenia gravis and twenty-three norrnal controls were included in this study. Mean AChR-Ab titers were 4.21+4.27nM in myasthenia gravis and 0.05+0.06nM in control group(p<0.05). Mean AChR-Ab titers of each clinical grade were 0.80+1.67nM in grade I, 5.05+3.42nN in grade Iia, 8.37+4.50nM in grade Iib, 6.67nM in grade m and 10.89nM in grade IV. There were significant correlation between clinical grade and level of AChR-AB titer. There were no correlation between degree of clinical improvement and changes of serum AChR-Ab titer after thymectomy in myasthenia gravis. There were also no correlation between level of AChR-Ab titers and histopathologic findings of thymus.
Subject(s)
Humans , Acetylcholine , Myasthenia Gravis , Thymectomy , Thymus GlandABSTRACT
This study was performed to evaluate the titer of serum acetylcholine receptor antibody (AChR-Ab), the correlation between AChR-Ab titer and clinical state, clinical response to thymectomy and histopathologic finding of thymus in myasthenia gravis. Twenty-seven patients with various clinical grades of myasthenia gravis and twenty-three norrnal controls were included in this study. Mean AChR-Ab titers were 4.21+4.27nM in myasthenia gravis and 0.05+0.06nM in control group(p<0.05). Mean AChR-Ab titers of each clinical grade were 0.80+1.67nM in grade I, 5.05+3.42nN in grade Iia, 8.37+4.50nM in grade Iib, 6.67nM in grade m and 10.89nM in grade IV. There were significant correlation between clinical grade and level of AChR-AB titer. There were no correlation between degree of clinical improvement and changes of serum AChR-Ab titer after thymectomy in myasthenia gravis. There were also no correlation between level of AChR-Ab titers and histopathologic findings of thymus.