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Aim To study the antitumor effect of cispl-atin ( DDP) chemotherapy promoted by Taohong Siwu Decoction (TSD) on mice with lung adenocarcinoma mice. Methods Lewis lung carcinoma cell line was used to make homologous lung adenocarcinoma trans¬plantation mouse model. Normal control, Model, TSD, DDP, TSD + DDP groups were set up. The change of transplanted tumor volume after administration was observed, the weight of transplanted tumor was weighed, the expression of Ki67 in transplanted tumor tissue was detected by immunohistochemistry, TUNEL was detected by fluorescence staining, Bcl-2, Bax, cleaved Caspase-3 and cleaved Caspase-9 were detected by immunoblotting, and the content of D-dirtier in plasma was measured by ELISA. Results DDP plus TSD significantly inhibited the growth of transplanted tumor. Ki67 expression in tumor tissue was lower than that in DDP group (28. 3% ±3. 1% vs 40. 3% ±2.1% ). The combined use of TSD and DDP significantly promoted the apoptosis level of transplanted tumor. The positive rate of TUNEL was significantly higher than that of DDP group (41. 0% ±3.0% vs 30.7% ± 4.5%). Bax, cleaved Caspase-3 and cleaved Caspase-9 expressions in tumor tissue were also higher than those of DDP group, while the expression of Bcl-2 was significantly lower than that of DDP group. Moreover, we found a significant interaction between TSD and DDP on the expression of four apoptotic proteins ( P < 0.05 ) . The plasma D-dimer content in TSD + DDP group was significantly lower than that in DDP group (188. 50 ± 28. 46 vs 269.80 ± 35.92) μg • L
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Purpose@#This study aimed to explore the motives of clinical nurses for experiencing empathy with patients and their families based on a self-determination theory framework. @*Methods@#Semi-structured face-to-face interviews with twenty-one nurses at four tertiary hospitals in Anhui, China, were conducted, recorded and transcribed. A content analysis with a directed approach was performed. @*Results@#An analysis of the interview transcripts revealed three categories of empathy motivation: autonomous motivation, controlled motivation and a lack of empathy motivation. Autonomous motivation included personal interests, enjoyment and a sense of value, pure altruism, assimilation, and recognition of the importance of empathy. Controlled motivation highlighted pressures from oneself and others, the possibility of tangible or intangible rewards, and avoidance of adverse effects. Finally, a lack of empathy motivation referred to a lack of intention for empathy and denial of the value of empathy. @*Conclusion@#This study provides a deep understanding of the motives underlying empathy in nurses. The results reveal the reasons for empathy and may support the development of effective strategies to foster and promote empathy in nurses.
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Purpose@#This study aimed to explore the motives of clinical nurses for experiencing empathy with patients and their families based on a self-determination theory framework. @*Methods@#Semi-structured face-to-face interviews with twenty-one nurses at four tertiary hospitals in Anhui, China, were conducted, recorded and transcribed. A content analysis with a directed approach was performed. @*Results@#An analysis of the interview transcripts revealed three categories of empathy motivation: autonomous motivation, controlled motivation and a lack of empathy motivation. Autonomous motivation included personal interests, enjoyment and a sense of value, pure altruism, assimilation, and recognition of the importance of empathy. Controlled motivation highlighted pressures from oneself and others, the possibility of tangible or intangible rewards, and avoidance of adverse effects. Finally, a lack of empathy motivation referred to a lack of intention for empathy and denial of the value of empathy. @*Conclusion@#This study provides a deep understanding of the motives underlying empathy in nurses. The results reveal the reasons for empathy and may support the development of effective strategies to foster and promote empathy in nurses.
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<p><b>OBJECTIVE</b>To explore the features of violence among primary and secondary school students in Hefei, and to set up intervention measures for violence prevention.</p><p><b>METHODS</b>Four schools in Hefei were randomly sampled in the study. A total of 3064 students completed a questionnaire.</p><p><b>RESULTS</b>16.22% of the pupils reported having suffered from violence at least once every month. The rate was higher in boys than that in girls's (chi(2) = 25.13, P = 0.000). The major assaulters were from classmates (45.80%), with hand beating (37.42%), insulting (31.21%), threatening (20.88%), and 10.49% using sticks and sharp weapons. Most violence occurred at school (46.08%), followed by at home (28.41%) and outside of schools (25.51%), with significant difference (P = 0.000). As a result, 3.33% ended up with fractures, and 0.51% with disability. 97 pupils reported having assaulted others frequently (3.21%). Being irritated (47.38%) was the major reason for the violence to occur.</p><p><b>CONCLUSION</b>Violence among primary and secondary school students in Hefei city was serious that called for targeted education be strengthened and school environment be improved.</p>