Early systemic administration of erythropoietin partially relieves cerebral vasospasm after subarachnoid hemorrhage in rabbits / 中华神经医学杂志

Objective To study the effect of carry systemic administration of erythropoietin (EPO)on cerebral vasospasm(cvs)after subarachnoid hemorrhage(SAH)and explore the possible mechanism. Methods Thirty male New Zealand rabbits were randomized equally into 5 groups.namely the blank control group, saline group,SAH model group,SAH+placebo group,and SAH+recombinant human erythropoietin(rHuEPO)group.In the latter 3 groups,rabbit SAH model was established by autologous blood injection into the cisterna magna,and in the saline group,only normal saline was injected.Fiveminutes after the blood injeetion,the rabbits received intraperitoneal injection of rHuEPO or placebo(EPO solvent)as indicated,followed by another 5 injections at the interval of8 h.Forty-eighthours after the model establishment,the rabbits were sacrificed by perfusion-fixation and the basiiar army Was taken.The cross-sectional area of the lumen of the basllar artery Was measured to evaluate the degree of cerebral vasospasm.TUNEL assay was used to detect endothelial cell apoptosis in the basilar artery. Results The average cross-sectional area of the basilar arteries showed no significant difference between the blank control and the saline groups or between SAH and SAH+placebo groups(P>0.05).The cross-sectional area of the basilar artery in SAH+rHuEPO group was significantly greater than that in SAH group and SAH+placebo group(P<0.05),but smaller than that in the blank control and saline groups.TUNEL assay revealed less intense apoptosis of the endothelial cells in SAH+rHuEPO group than in SAH group or SAH+placebo group(P0.05).Conclusion Early systemic administration of rHuEPO can decrease endothelial cell apoptosis in the basilar artery and may partially attenuate the intensity of CVS in rabbits with SAH.

The analysis of complications after surgical treatment of primary brain stem diseases / 中华外科杂志

<p><b>OBJECTIVE</b>To analyze the complications of the surgical treatment on primary brain stem diseases.</p><p><b>METHODS</b>From January 2000 to December 2005, 38 patients with primary brain stem diseases underwent surgical operation. The data of the patients were retrospectively analyzed.</p><p><b>RESULTS</b>The incidence of complication was 97% (37/38), and the mortality rate was 3% (1/38). The rate of hypesthesia was 37% (14/38), and 43% (6/14) improved 3 month after operation. Hemiplegia rate was 55% (21/38), and the recovery rate was 57% (12/21), the others improved. Disturbance of eyes movement happened in 7 patients among 8 diencephalon disease patients, 5 patients recovered. The rate of facial paresis among pons disease patients was 77% (10/13), 4 patients recovered. Severe complication such as disturbance of consciousness, breath and circulation failure were very low, and the outcome was very good.</p><p><b>CONCLUSIONS</b>The rate of complication that affects living quality is low, most of complications are improved. It means that the complication of brain stem operation is acceptable, so the brain stem disease should be treated actively.</p>

Male infertility caused by pituitary adenoma / 中华男科学杂志

Pituitary adenoma is one of the important etiologies of male infertility. The early diagnosis of pituitary adenoma that caused infertility is not difficult with the help of modem incretion examination and imaging technique. The treatment focused on pituitary adenoma is no doubt the optimal choice of this kind of male infertility.

Clinical and pathological characteristics of intracranial haemangioblastoma / 中华外科杂志

<p><b>OBJECTIVE</b>To analyze and summarize the clinical and pathological characteristics of intracranial haemangioblastoma and to improve surgery effect.</p><p><b>METHOD</b>Seventy-two patients with intracranial haemangioblastoma who were proven by operation and pathology from 1970 to 1988 were analyzed retrospectively.</p><p><b>RESULTS</b>Intracranial haemangioblastoma tends to occur in the hemisphere of cerebellum (83 tumours, 87%) and the age of them ranged from 20 to 40 years (47 cases, 58.3%) mostly. The ratio of men (46 cases) was higher than women (26 cases). The diagnosis of the disease depends on CT and MR substantive haemangioblastoma. The most effective and reliable treatment of intracranial haemangioblastoma is surgical resection.</p><p><b>CONCLUSION</b>Intracranial haemangioblastoma is benign tumour which can be, cured by total surgical resection. The key recurrence factors include the young age of initial onset, mistaken exploration and incomplete extirpation of tumour.</p>