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China Journal of Chinese Materia Medica ; (24): 340-343, 2005.
Article in Chinese | WPRIM | ID: wpr-279168

ABSTRACT

A processing method to enhance thrombolytic effect of Carthamus tinctorius using a fermentation technology with bacillus sp. C2-13 was investigated. The fibrinolysis and anticoagulation activity of thrombolytic extracts from an optimized fermentation process was studied using a carrageenan induced mice model. The fermented extracts resulted in significantly better thrombolytic activity, suggesting that the process was promising for use in the study and preparation of nature medicines.


Subject(s)
Animals , Female , Male , Mice , Rats , Bacillus , Carthamus tinctorius , Chemistry , Microbiology , Drugs, Chinese Herbal , Pharmacology , Fermentation , Fibrinolysis , Fibrinolytic Agents , Pharmacology , Partial Thromboplastin Time , Prothrombin Time , Rats, Sprague-Dawley , Thrombin Time
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