ABSTRACT
Objective To evaluate the left ventricular segmental and global systolic myocardial function of the hypertrophic obstructive cardiomyopathy (HOCM) before and after transcoronary ablation of septal hypertrophy (TASH).Methods Twenty-six consecutive patients with HOCM were analysed by two-dimensional speckle tracking imaging (STI) before and after TASH.The left ventricular global and segmental systolic longitudinal strains and circumferential strain were measured.Results In the HOCM patients,the global and segmental longitudinal strains were lower than the healthy population before TASH.One week after TASH,a significant reduction of left ventricular outflow tract (LVOT) gradients occurred (P ＜ 0.001).The global and the alcohol-treated septal segmental longitudinal strains also decreased significantly[(-12.5±1.7)％ vs (-13.6± 1.6)％,P＜0.01;(-11.2±2.8)％ vs (-12.6±3.1)％,P ＜ 0.001].During 1 year follow-up after TASH,the mean NYHA function class improved after TASH (P ＜ 0.001) and the left ventricular outflow tract (LVOT) gradients and septal thickness decreased (P ＜0.001).The left ventricular global longitudinal systolic strain was increased [(-14.7 ± 2.0) ％ vs (-13.6 ±1.6) ％,P ＜0.01],and this was correlated with the decrease of the LVOT gradients (r =0.579,P ＜0.01).The alcohol-treated septal segments showed unchanged average longitudinal strain over time,while in the anterolateral and the anterior segments,the average longitudinal systolic strain increased (P ＜0.05).The basal and medial segments also showed increased average longitudinal systolic stain.However,the left ventricular circumferential strain had no changes after TASH.Conclusions TASH can significantly decrease the LVOT gradients and improve NYHA functional class with the increase of the left ventricular global and segmental longitudinal systolic function.